| Transaction Date | Insider | Transaction Type | Number of Shares Transacted |
|---|---|---|---|
| 2003-11-07 | LOBELL J JAY | Purchase | 9718.0 |
| 2003-11-07 | LOBELL J JAY | Purchase | 24294.0 |
| 2004-02-26 | GIMBERT JOAN PONS | Sale | 200000.0 |
| 2004-08-17 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2004-08-17 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2004-08-24 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2004-09-03 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2004-09-09 | ROSENWALD LINDSAY A MD | Purchase | 1000.0 |
| 2004-09-28 | ROSENWALD LINDSAY A MD | Purchase | 3000.0 |
| 2004-09-28 | ROSENWALD LINDSAY A MD | Purchase | 2000.0 |
| 2004-09-28 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2004-10-04 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2004-10-04 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2004-10-13 | ROSENWALD LINDSAY A MD | Purchase | 6500.0 |
| 2004-10-13 | ROSENWALD LINDSAY A MD | Purchase | 0.0 |
| 2004-10-13 | ROSENWALD LINDSAY A MD | Purchase | 0.0 |
| 2004-10-13 | ROSENWALD LINDSAY A MD | Purchase | 0.0 |
| 2004-10-14 | ROSENWALD LINDSAY A MD | Purchase | 3500.0 |
| 2005-01-06 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-07 | ROSENWALD LINDSAY A MD | Purchase | 2500.0 |
| 2005-01-07 | ROSENWALD LINDSAY A MD | Purchase | 7500.0 |
| 2005-01-10 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-10 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-12 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-13 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-14 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-18 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-19 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-20 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-20 | ROSENWALD LINDSAY A MD | Purchase | 15000.0 |
| 2005-01-21 | ROSENWALD LINDSAY A MD | Purchase | 8600.0 |
| 2005-01-21 | ROSENWALD LINDSAY A MD | Purchase | 4000.0 |
| 2005-01-21 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-24 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-24 | ROSENWALD LINDSAY A MD | Purchase | 7500.0 |
| 2005-01-28 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-01-31 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-02-01 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-02-02 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-02-04 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-02-07 | ROSENWALD LINDSAY A MD | Purchase | 10000.0 |
| 2005-02-08 | ROSENWALD LINDSAY A MD | Purchase | 6500.0 |
| 2005-02-10 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-02-14 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-02-16 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-02-17 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-02-18 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-02-25 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-03-01 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-03-08 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-03-17 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-03-18 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-03-22 | ROSENWALD LINDSAY A MD | Purchase | 500.0 |
| 2005-03-24 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-03-28 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-03-29 | ROSENWALD LINDSAY A MD | Purchase | 4000.0 |
| 2005-03-29 | ROSENWALD LINDSAY A MD | Purchase | 1000.0 |
| 2005-03-30 | ROSENWALD LINDSAY A MD | Purchase | 1700.0 |
| 2005-04-01 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-01 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-01 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-07 | ROSENWALD LINDSAY A MD | Purchase | 4000.0 |
| 2005-04-07 | ROSENWALD LINDSAY A MD | Purchase | 1000.0 |
| 2005-04-08 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-12 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-13 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-14 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-15 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-19 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-21 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-21 | ABEL DOUGLAS | Purchase | 2500.0 |
| 2005-04-22 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-22 | ABEL DOUGLAS | Purchase | 2500.0 |
| 2005-04-25 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-25 | ABEL DOUGLAS | Purchase | 2500.0 |
| 2005-04-26 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-26 | ABEL DOUGLAS | Purchase | 2500.0 |
| 2005-04-27 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-04-27 | Herskowitz Neil | Purchase | 5000.0 |
| 2005-04-28 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-05-03 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-05-04 | ROSENWALD LINDSAY A MD | Purchase | 1000.0 |
| 2005-05-04 | ROSENWALD LINDSAY A MD | Purchase | 2000.0 |
| 2005-05-04 | ROSENWALD LINDSAY A MD | Purchase | 2000.0 |
| 2005-05-09 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-05-11 | ROSENWALD LINDSAY A MD | Purchase | 5000.0 |
| 2005-10-20 | ABEL DOUGLAS | Purchase | 5000.0 |
| 2005-10-21 | ABEL DOUGLAS | Purchase | 5000.0 |
| 2005-11-18 | ABEL DOUGLAS | Purchase | 5000.0 |
| 2006-01-10 | Herskowitz Neil | Purchase | 14200.0 |
| 2006-07-10 | ABEL DOUGLAS | Purchase | 5000.0 |
| 2006-07-10 | Herskowitz Neil | Purchase | 500.0 |
| 2006-07-11 | Herskowitz Neil | Purchase | 4500.0 |
| 2006-07-12 | WEISER MICHAEL | Purchase | 1800.0 |
| 2006-07-12 | WEISER MICHAEL | Purchase | 3200.0 |
| 2006-07-13 | Herskowitz Neil | Purchase | 2500.0 |
| 2006-07-18 | Herskowitz Neil | Purchase | 2500.0 |
| 2007-03-30 | Herskowitz Neil | Purchase | 55555.0 |
| 2007-03-30 | Herskowitz Neil | Purchase | 19444.0 |
| 2012-05-16 | WEISS MICHAEL S | Purchase | 1500.0 |
| 2012-09-10 | WEISS MICHAEL S | Purchase | 50000.0 |
| 2012-09-11 | WEISS MICHAEL S | Purchase | 100000.0 |
| 2012-09-13 | Power Sean A | Purchase | 1000.0 |
| 2012-09-14 | Power Sean A | Purchase | 3400.0 |
| 2012-12-06 | Herskowitz Neil | Purchase | 1000.0 |
| 2013-12-11 | WEISS MICHAEL S | Purchase | 10000.0 |
| 2014-12-16 | Power Sean A | Sale | 38041.0 |
| 2014-12-16 | WEISS MICHAEL S | Sale | 210618.0 |
| 2015-01-05 | Power Sean A | Sale | 54057.0 |
| 2015-01-07 | Power Sean A | Sale | 12344.0 |
| 2015-02-17 | LFB Biotechnologies S.A.S.U. | Purchase | 114855.0 |
| 2015-04-01 | Power Sean A | Sale | 12800.0 |
| 2015-04-02 | Power Sean A | Sale | 11000.0 |
| 2015-07-01 | Power Sean A | Sale | 50054.0 |
| 2015-07-08 | KENNEDY WILLIAM JAMES | Sale | 17000.0 |
| 2016-01-05 | Power Sean A | Sale | 22790.0 |
| 2016-04-18 | Power Sean A | Sale | 10000.0 |
| 2016-07-05 | Power Sean A | Sale | 50426.0 |
| 2017-01-04 | Power Sean A | Sale | 8816.0 |
| 2017-04-04 | Charney Laurence N | Sale | 7000.0 |
| 2017-04-11 | KENNEDY WILLIAM JAMES | Sale | 8548.0 |
| 2017-06-16 | Power Sean A | Sale | 29976.0 |
| 2017-06-19 | Power Sean A | Sale | 30000.0 |
| 2018-01-02 | Power Sean A | Sale | 32006.0 |
| 2018-06-14 | KENNEDY WILLIAM JAMES | Sale | 25071.0 |
| 2018-07-02 | Power Sean A | Sale | 12191.0 |
| 2018-07-03 | Power Sean A | Sale | 35000.0 |
| 2019-01-02 | Power Sean A | Sale | 37275.0 |
| 2019-06-26 | WEISS MICHAEL S | Purchase | 50000.0 |
| 2019-07-01 | Power Sean A | Sale | 17654.0 |
| 2020-06-17 | KENNEDY WILLIAM JAMES | Sale | 7745.0 |
| 2020-09-09 | RA CAPITAL MANAGEMENT, L.P. | Sale | 158589.0 |
| 2020-12-10 | Echelard Y | Sale | 30000 |
| Transaction Date) | Insider | Transaction Type | Number of Shares Transacted |