Transaction Date Insider Transaction Type Number of Shares Transacted
2004-06-02 van Osch Martien Purchase 140000.0
2004-06-02 Hacksell Uli Purchase 300.0
2004-06-02 GORDON CARL L Purchase 90000.0
2004-06-02 GORDON CARL L Purchase 60000.0
2004-06-02 WALTON ALAN G Purchase 282169.0
2004-06-02 WALTON ALAN G Purchase 2831.0
2004-06-02 OXFORD BIOSCIENCE PARTNERS IV LP Purchase 282169.0
2004-06-02 OXFORD BIOSCIENCE PARTNERS IV LP Purchase 2831.0
2005-04-20 OXFORD BIOSCIENCE PARTNERS IV LP Purchase 586402.0
2005-04-20 OXFORD BIOSCIENCE PARTNERS IV LP Purchase 146600.0
2005-04-20 GORDON CARL L Purchase 359603.0
2005-04-20 van Osch Martien Purchase 366501.0
2005-07-29 OXFORD BIOSCIENCE PARTNERS IV LP Purchase 89900.0
2005-09-16 Brann Mark R Sale 20000.0
2005-09-16 Brann Mark R Sale 5000.0
2005-09-16 Brann Mark R Sale 15000.0
2005-12-20 Brann Mark R Sale 10000.0
2005-12-20 Brann Mark R Sale 10000.0
2006-01-03 Brann Mark R Sale 3500.0
2006-01-04 Brann Mark R Sale 3000.0
2006-01-05 Brann Mark R Sale 7500.0
2006-01-06 Brann Mark R Sale 6000.0
2006-02-15 Aasen Thomas H Sale 12000.0
2006-03-17 Brann Mark R Sale 1500.0
2006-03-17 Brann Mark R Sale 12500.0
2006-03-20 Brann Mark R Sale 16000.0
2006-03-20 Brann Mark R Sale 5000.0
2006-03-20 Brann Mark R Sale 5000.0
2006-05-18 Aasen Thomas H Sale 8000.0
2006-06-16 Brann Mark R Sale 20000.0
2006-08-24 Aasen Thomas H Sale 8000.0
2007-05-16 Hacksell Uli Sale 12901.0
2007-05-16 Hacksell Uli Sale 10000.0
2007-05-16 Hacksell Uli Sale 8499.0
2007-05-16 Hacksell Uli Sale 1500.0
2007-05-16 Hacksell Uli Sale 1300.0
2007-05-16 Hacksell Uli Sale 800.0
2007-08-13 Lundstrom Brian Sale 982.0
2007-08-13 Lundstrom Brian Sale 1800.0
2007-08-13 Lundstrom Brian Sale 200.0
2007-08-13 Lundstrom Brian Sale 528.0
2007-08-14 Lundstrom Brian Sale 400.0
2007-08-14 Lundstrom Brian Sale 4600.0
2007-08-15 Aasen Thomas H Sale 3000.0
2007-08-15 Aasen Thomas H Sale 3000.0
2007-08-15 Aasen Thomas H Sale 4000.0
2007-08-15 Aasen Thomas H Sale 3000.0
2007-08-15 Aasen Thomas H Sale 3000.0
2007-09-04 Hacksell Uli Sale 900.0
2007-09-04 Hacksell Uli Sale 200.0
2007-09-04 Hacksell Uli Sale 2400.0
2007-09-04 Hacksell Uli Sale 372.0
2007-09-04 Hacksell Uli Sale 400.0
2007-09-04 Hacksell Uli Sale 4728.0
2007-09-04 Hacksell Uli Sale 400.0
2007-09-04 Hacksell Uli Sale 100.0
2007-09-04 Hacksell Uli Sale 100.0
2007-09-04 Hacksell Uli Sale 2400.0
2007-09-04 Hacksell Uli Sale 200.0
2007-09-04 Hacksell Uli Sale 800.0
2007-09-04 Hacksell Uli Sale 1000.0
2007-09-12 Lundstrom Brian Sale 4300.0
2007-09-12 Lundstrom Brian Sale 100.0
2007-09-12 Lundstrom Brian Sale 700.0
2007-09-20 Lundstrom Brian Sale 1318.0
2007-09-20 Lundstrom Brian Sale 100.0
2007-11-14 Aasen Thomas H Sale 4000.0
2007-11-14 Aasen Thomas H Sale 1900.0
2007-11-14 Aasen Thomas H Sale 100.0
2007-11-14 Aasen Thomas H Sale 2000.0
2007-12-06 Aasen Thomas H Sale 2000.0
2007-12-06 Aasen Thomas H Sale 2000.0
2007-12-06 Lundstrom Brian Sale 6500.0
2007-12-06 Lundstrom Brian Sale 1000.0
2007-12-06 Lundstrom Brian Sale 4900.0
2007-12-06 Lundstrom Brian Sale 100.0
2007-12-06 Hacksell Uli Sale 1000.0
2007-12-06 Hacksell Uli Sale 300.0
2007-12-06 Hacksell Uli Sale 2800.0
2007-12-06 Hacksell Uli Sale 2500.0
2007-12-06 Hacksell Uli Sale 1100.0
2007-12-06 Hacksell Uli Sale 1200.0
2007-12-06 Hacksell Uli Sale 900.0
2007-12-06 Hacksell Uli Sale 4200.0
2008-02-13 Aasen Thomas H Sale 4000.0
2008-02-13 Aasen Thomas H Sale 2000.0
2008-02-13 Aasen Thomas H Sale 2000.0
2009-05-18 Iversen Leslie L Purchase 3000.0
2012-11-27 Aasen Thomas H Sale 30900.0
2012-11-27 Baity Glenn Sale 16206.0
2012-11-28 Aasen Thomas H Sale 9100.0
2012-11-28 Baity Glenn Sale 4396.0
2013-04-01 Aasen Thomas H Sale 40000.0
2013-04-01 Hacksell Uli Sale 40000.0
2013-04-01 Mills Roger Sale 58584.0
2013-04-02 Baity Glenn Sale 13163.0
2013-04-11 Aasen Thomas H Sale 40000.0
2013-04-11 Baity Glenn Sale 10000.0
2013-04-11 Baity Glenn Sale 10000.0
2013-04-11 Baity Glenn Sale 10000.0
2013-04-12 Baity Glenn Sale 20000.0
2013-04-12 Baity Glenn Sale 10000.0
2013-04-15 Baity Glenn Sale 20000.0
2013-04-16 Hacksell Uli Sale 16729.0
2013-04-16 Baity Glenn Sale 20000.0
2013-04-17 Baity Glenn Sale 10000.0
2013-04-22 Baity Glenn Sale 10000.0
2013-05-01 Hacksell Uli Sale 19551.0
2013-05-02 Hacksell Uli Sale 20449.0
2013-05-15 BAKER FELIX Purchase 218846.0
2013-05-15 BAKER FELIX Purchase 1730970.0
2013-05-15 BAKER FELIX Purchase 43184.0
2013-06-03 BAKER FELIX Purchase 56274.0
2013-06-03 BAKER FELIX Purchase 461548.0
2013-06-03 BAKER FELIX Purchase 11511.0
2013-06-03 BAKER FELIX Purchase 25368.0
2013-06-03 BAKER FELIX Purchase 208063.0
2013-06-03 BAKER FELIX Purchase 5189.0
2013-06-04 BAKER FELIX Purchase 4353.0
2013-06-04 BAKER FELIX Purchase 35702.0
2013-06-04 BAKER FELIX Purchase 890.0
2013-06-04 BAKER FELIX Purchase 56475.0
2013-06-04 BAKER FELIX Purchase 463197.0
2013-06-04 BAKER FELIX Purchase 11552.0
2013-06-04 BAKER FELIX Purchase 13566.0
2013-06-04 BAKER FELIX Purchase 111266.0
2013-06-04 BAKER FELIX Purchase 2775.0
2013-06-05 BAKER FELIX Purchase 26577.0
2013-06-05 BAKER FELIX Purchase 217986.0
2013-06-05 BAKER FELIX Purchase 5437.0
2013-06-05 BAKER FELIX Purchase 21080.0
2013-06-05 BAKER FELIX Purchase 172893.0
2013-06-05 BAKER FELIX Purchase 4312.0
2013-06-05 BAKER FELIX Purchase 18530.0
2013-06-05 BAKER FELIX Purchase 151980.0
2013-06-05 BAKER FELIX Purchase 3790.0
2013-06-05 BAKER FELIX Purchase 26577.0
2013-06-05 BAKER FELIX Purchase 217986.0
2013-06-05 BAKER FELIX Purchase 5437.0
2013-08-13 Aasen Thomas H Sale 60000.0
2013-08-13 Hacksell Uli Sale 52771.0
2013-08-26 GRAY MARY ANN Sale 5000.0
2013-08-26 GRAY MARY ANN Sale 10000.0
2013-09-03 Rasmussen Torsten Sale 40000.0
2013-09-10 Brege Laura Sale 46153.0
2013-09-12 KAPLAN LESTER J PH D Sale 66356.0
2013-09-12 Iversen Leslie L Sale 60000.0
2013-09-20 Mills Roger Sale 35965.0
2013-10-01 Aasen Thomas H Sale 30000.0
2013-10-10 Brege Laura Sale 10000.0
2013-11-01 Hacksell Uli Sale 15000.0
2013-11-01 Rasmussen Torsten Sale 37692.0
2013-12-02 Hacksell Uli Sale 15000.0
2013-12-10 Brege Laura Sale 44117.0
2014-01-02 Aasen Thomas H Sale 30000.0
2014-01-02 Iversen Leslie L Sale 60000.0
2014-01-15 Hacksell Uli Sale 25000.0
2014-01-15 Brege Laura Sale 10000.0
2014-02-18 Hacksell Uli Sale 25000.0
2014-02-26 Baity Glenn Sale 42000.0
2014-03-05 BAKER BROS. ADVISORS LP Purchase 38934.0
2014-03-05 BAKER BROS. ADVISORS LP Purchase 475644.0
2014-03-05 BAKER BROS. ADVISORS LP Purchase 11738.0
2014-04-04 Aasen Thomas H Sale 15000.0
2014-04-04 Rasmussen Torsten Sale 30000.0
2014-04-04 Brege Laura Sale 14285.0
2014-04-15 Hacksell Uli Sale 25000.0
2014-05-01 Rasmussen Torsten Sale 32857.0
2014-06-02 KAPLAN LESTER J PH D Sale 4450.0
2014-06-09 Wells William McDowall Sale 15000.0
2014-06-16 Hacksell Uli Sale 20000.0
2014-07-14 Hacksell Uli Sale 20000.0
2014-08-15 Hacksell Uli Sale 15000.0
2014-09-02 Wells William McDowall Sale 15000.0
2014-09-02 Wells William McDowall Sale 15000.0
2014-09-02 KAPLAN LESTER J PH D Sale 57692.0
2014-09-10 Hacksell Uli Sale 30000.0
2014-09-12 Wells William McDowall Sale 9190.0
2014-09-15 Brege Laura Sale 10000.0
2014-10-08 Hacksell Uli Sale 30000.0
2014-11-21 Wells William McDowall Sale 5810.0
2014-11-24 Hacksell Uli Sale 30000.0
2014-11-26 Mills Roger Sale 25000.0
2014-11-26 BORER MICHAEL T Sale 15000.0
2014-12-15 Hacksell Uli Sale 30000.0
2014-12-15 GRAY MARY ANN Sale 12250.0
2015-01-13 GRAY MARY ANN Sale 4250.0
2015-01-13 Rasmussen Torsten Sale 11905.0
2015-01-14 Hacksell Uli Sale 30000.0
2015-01-15 BORER MICHAEL T Sale 27973.0
2015-02-11 Brege Laura Sale 10000.0
2015-02-17 Hacksell Uli Sale 30000.0
2015-02-17 Rasmussen Torsten Sale 19847.0
2015-11-11 Iversen Leslie L Sale 30000.0
2016-01-07 BAKER BROS. ADVISORS LP Purchase 785045.0
2016-01-07 BAKER BROS. ADVISORS LP Purchase 1801161.0
2016-01-07 14159, L.P. Purchase 785045.0
2016-01-07 14159, L.P. Purchase 1801161.0
2016-03-02 Baity Glenn Sale 7000.0
2016-03-30 BAKER BROS. ADVISORS LP Purchase 408607.0
2016-03-30 BAKER BROS. ADVISORS LP Purchase 37882.0
2016-03-30 BAKER BROS. ADVISORS LP Purchase 16057.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 1614.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 14775.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 1467.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 13433.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 19676.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 180122.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 3106.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 28433.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 6618.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 60587.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 34844.0
2016-03-31 BAKER BROS. ADVISORS LP Purchase 318969.0
2016-04-01 BAKER BROS. ADVISORS LP Purchase 1182.0
2016-04-01 BAKER BROS. ADVISORS LP Purchase 10818.0
2016-04-01 BAKER BROS. ADVISORS LP Purchase 28647.0
2016-04-01 BAKER BROS. ADVISORS LP Purchase 262253.0
2016-04-18 Iversen Leslie L Sale 33697.0
2016-07-11 Baity Glenn Sale 4057.0
2016-07-12 Baity Glenn Sale 11943.0
2016-08-10 BAKER BROS. ADVISORS LP Purchase 133153.0
2016-08-10 BAKER BROS. ADVISORS LP Purchase 1169877.0
2016-08-16 HARRIGAN EDMUND Purchase 1000.0
2016-11-10 Baity Glenn Sale 10200.0
2016-12-20 Baity Glenn Sale 10000.0
2016-12-27 Baity Glenn Sale 9800.0
2017-02-01 Baity Glenn Sale 31078.0
2017-02-14 Baity Glenn Sale 26365.0
2017-02-14 Moore Terrence O Sale 89088.0
2017-02-15 Moore Terrence O Sale 1700.0
2017-02-16 Moore Terrence O Sale 66752.0
2017-02-21 Moore Terrence O Sale 7856.0
2017-06-22 Baity Glenn Sale 1903.0
2017-07-20 Baity Glenn Sale 38097.0
2017-08-09 Baity Glenn Sale 14322.0
2017-08-30 Baity Glenn Sale 26507.0
2017-10-05 Baity Glenn Sale 37500.0
2018-01-02 Brege Laura Sale 25000.0
2018-01-02 Baity Glenn Sale 74321.0
2018-01-29 Baity Glenn Sale 36558.0
2018-03-01 SOLAND DANIEL B Purchase 2000.0
2018-03-01 SOLAND DANIEL B Purchase 3000.0
2018-03-01 SOLAND DANIEL B Purchase 2000.0
2018-03-02 SOLAND DANIEL B Purchase 3000.0
2018-09-20 BAKER BROS. ADVISORS LP Purchase 102267.0
2018-09-20 BAKER BROS. ADVISORS LP Purchase 920495.0
2018-09-20 BAKER BROS. ADVISORS LP Purchase 4245.0
2018-09-20 BAKER BROS. ADVISORS LP Purchase 38207.0
2018-09-20 BAKER BROS. ADVISORS LP Purchase 14555.0
2018-09-20 BAKER BROS. ADVISORS LP Purchase 131007.0
2018-11-30 BAKER BROS. ADVISORS LP Purchase 585882.0
2018-11-30 BAKER BROS. ADVISORS LP Purchase 11178823.0
2019-01-09 Brege Laura Sale 10000.0
2019-09-09 Daly James M Sale 29600.0
2019-09-09 Daly James M Sale 400.0
2019-09-09 Miller Eric Alejandro Sale 28467.0
2019-09-11 Miller Eric Alejandro Sale 4645.0
2019-09-20 BAKER BROS. ADVISORS LP Purchase 68475.0
2019-09-20 BAKER BROS. ADVISORS LP Purchase 1494025.0
2019-10-09 DAVIS STEPHEN Sale 29792.0
2019-10-10 DAVIS STEPHEN Sale 120208.0
2019-10-15 DAVIS STEPHEN Sale 2983.0
2019-10-15 Stankovic Srdjan R. Sale 1031.0
2019-10-15 YANG MICHAEL J. Sale 877.0
2019-10-15 Miller Eric Alejandro Sale 147.0
2019-11-19 Stankovic Srdjan R. Sale 2160.0
2019-12-05 DAVIS STEPHEN Sale 81585.0
2019-12-05 DAVIS STEPHEN Sale 40159.0
2019-12-05 DAVIS STEPHEN Sale 28256.0
2019-12-09 Ridloff Elena Sale 11020.0
2019-12-09 Ridloff Elena Sale 5502.0
2019-12-09 Ridloff Elena Sale 19478.0
2019-12-09 YANG MICHAEL J. Sale 11019.0
2019-12-09 YANG MICHAEL J. Sale 3502.0
2019-12-11 KIM AUSTIN D. Sale 17500.0
2019-12-12 YANG MICHAEL J. Sale 100447.0
2019-12-12 YANG MICHAEL J. Sale 5032.0
2020-01-07 Brege Laura Sale 10000.0
2020-03-16 BAKER BROS. ADVISORS LP Purchase 497.0
2020-03-16 BAKER BROS. ADVISORS LP Purchase 5503.0
2020-03-16 BAKER BROS. ADVISORS LP Purchase 57022.0
2020-03-16 BAKER BROS. ADVISORS LP Purchase 631281.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 353.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 3913.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 3903.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 43212.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 688.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 7612.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 2676.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 29624.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 2188.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 24223.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 8402.0
2020-03-17 BAKER BROS. ADVISORS LP Purchase 93006.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 25.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 275.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 4175.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 46225.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 199.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 2201.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 3023.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 33464.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 3837.0
2020-03-18 BAKER BROS. ADVISORS LP Purchase 42473.0
2020-04-20 Stankovic Srdjan R. Sale 100000.0
2020-04-22 Stankovic Srdjan R. Sale 54019.0
2020-04-23 Stankovic Srdjan R. Sale 18949.0
2020-04-29 Ridloff Elena Sale 10000.0
2020-04-30 Stankovic Srdjan R. Sale 4308.0
2020-04-30 Ridloff Elena Sale 1050.0
2020-04-30 DAVIS STEPHEN Sale 6770.0
2020-04-30 YANG MICHAEL J. Sale 1501.0
2020-04-30 KIM AUSTIN D. Sale 1072.0
2020-05-11 Daly James M Sale 26250.0
2020-05-13 DAVIS STEPHEN Sale 13908.0
2020-05-13 DAVIS STEPHEN Sale 5205.0
2020-05-13 DAVIS STEPHEN Sale 20756.0
2020-05-13 DAVIS STEPHEN Sale 63392.0
2020-05-13 DAVIS STEPHEN Sale 8197.0
2020-05-14 DAVIS STEPHEN Sale 84221.0
2020-05-14 DAVIS STEPHEN Sale 4321.0
2020-06-18 Stankovic Srdjan R. Sale 65843.0
2020-06-19 Stankovic Srdjan R. Sale 16452.0
2020-07-07 YANG MICHAEL J. Sale 16150.0
2020-07-07 YANG MICHAEL J. Sale 11100.0
2020-10-16 DAVIS STEPHEN Sale 2960.0
2020-10-16 Stankovic Srdjan R. Sale 1297.0
2020-10-16 YANG MICHAEL J. Sale 1247.0
2020-10-27 KIM AUSTIN D. Sale 8750.0
2020-11-20 Stankovic Srdjan R. Sale 2728
2021-01-06 YANG MICHAEL J. Sale 1120
2021-01-06 KIM AUSTIN D. Sale 678
2021-01-06 Ridloff El Sale 1016
2021-01-08 Stankovic Srdjan R. Sale 29733
2021-01-07 Stankovic Srdjan R. Sale 61619
2021-01-06 Stankovic Srdjan R. Sale 1725
2021-01-06 DAVIS STEPHEN Sale 3484
2021-01-12 Stankovic Srdjan R. Sale 700
2021-02-04 Ridloff El Sale 2051
2021-02-04 DAVIS STEPHEN Sale 14195
2021-02-04 Stankovic Srdjan R. Sale 8429
2021-02-04 KIM AUSTIN D. Sale 2107
Transaction Date) Insider Transaction Type Number of Shares Transacted