Transaction Date Insider Transaction Type Number of Shares Transacted
2015-06-24 MORE ROBERT J Purchase 5000.0
2015-11-12 WEISNER AIMEE S Purchase 2500.0
2015-12-31 HARRISON RICHARD L Purchase 1388.0
2015-12-31 Burns Thomas William Purchase 1388.0
2016-02-25 MONTREUX EQUITY PARTNERS IV LP Sale 70000.0
2016-03-04 WEISNER AIMEE S Purchase 2500.0
2016-05-03 Calcaterra Chris M. Sale 700.0
2016-05-03 HARRISON RICHARD L Sale 1100.0
2016-05-03 Burns Thomas William Sale 800.0
2016-05-04 Calcaterra Chris M. Sale 4383.0
2016-05-04 Calcaterra Chris M. Sale 1453.0
2016-05-04 Calcaterra Chris M. Sale 51115.0
2016-05-04 Calcaterra Chris M. Sale 16885.0
2016-05-04 HARRISON RICHARD L Sale 2031.0
2016-05-04 HARRISON RICHARD L Sale 137.0
2016-05-04 HARRISON RICHARD L Sale 25069.0
2016-05-04 HARRISON RICHARD L Sale 1663.0
2016-05-04 Burns Thomas William Sale 34100.0
2016-05-04 Burns Thomas William Sale 1800.0
2016-05-25 Burns Thomas William Sale 300.0
2016-05-31 VERSANT VENTURES I LLC Sale 10970.0
2016-05-31 VERSANT VENTURES I LLC Sale 23088.0
2016-05-31 VERSANT VENTURES I LLC Sale 10970.0
2016-05-31 VERSANT VENTURES I LLC Sale 23088.0
2016-05-31 LINK WILLIAM J PHD Sale 10970.0
2016-05-31 LINK WILLIAM J PHD Sale 23088.0
2016-06-01 Burns Thomas William Sale 25000.0
2016-06-03 Burns Thomas William Sale 422.0
2016-06-06 Burns Thomas William Sale 24578.0
2016-06-15 Calcaterra Chris M. Sale 45464.0
2016-06-20 HARRISON RICHARD L Sale 4300.0
2016-06-20 Burns Thomas William Sale 7997.0
2016-07-01 Burns Thomas William Sale 50000.0
2016-07-12 HARRISON RICHARD L Sale 5700.0
2016-07-12 Burns Thomas William Sale 10500.0
2016-07-13 Burns Thomas William Sale 151754.0
2016-07-27 HARRISON RICHARD L Sale 10000.0
2016-08-03 ORBIMED ADVISORS LLC Sale 420990.0
2016-08-03 ORBIMED ADVISORS LLC Sale 4010.0
2016-08-03 SILVERSTEIN JONATHAN Sale 420990.0
2016-08-03 SILVERSTEIN JONATHAN Sale 4010.0
2016-08-10 SILVERSTEIN JONATHAN Sale 116825.0
2016-08-10 SILVERSTEIN JONATHAN Sale 1113.0
2016-08-10 ORBIMED ADVISORS LLC Sale 116825.0
2016-08-10 ORBIMED ADVISORS LLC Sale 1113.0
2016-08-11 SILVERSTEIN JONATHAN Sale 159382.0
2016-08-11 SILVERSTEIN JONATHAN Sale 1518.0
2016-08-11 ORBIMED ADVISORS LLC Sale 159382.0
2016-08-11 ORBIMED ADVISORS LLC Sale 1518.0
2016-08-12 SILVERSTEIN JONATHAN Sale 13967.0
2016-08-12 SILVERSTEIN JONATHAN Sale 133.0
2016-08-12 ORBIMED ADVISORS LLC Sale 13967.0
2016-08-12 ORBIMED ADVISORS LLC Sale 133.0
2016-10-20 Calcaterra Chris M. Sale 37000.0
2016-10-20 Calcaterra Chris M. Sale 3000.0
2016-10-24 Calcaterra Chris M. Sale 20000.0
2016-11-14 Burns Thomas William Sale 186515.0
2016-11-14 Burns Thomas William Sale 3605.0
2016-11-15 Burns Thomas William Sale 10000.0
2016-11-17 LINK WILLIAM J PHD Sale 30000.0
2017-01-06 HARRISON RICHARD L Sale 20574.0
2017-01-06 HARRISON RICHARD L Sale 60.0
2017-01-09 Calcaterra Chris M. Sale 20000.0
2017-01-09 Burns Thomas William Sale 40000.0
2017-01-12 Calcaterra Chris M. Sale 14413.0
2017-01-12 HARRISON RICHARD L Sale 14321.0
2017-01-13 Calcaterra Chris M. Sale 3723.0
2017-01-13 HARRISON RICHARD L Sale 6313.0
2017-02-02 Burns Thomas William Sale 50000.0
2017-03-03 ORBIMED ADVISORS LLC Sale 55246.0
2017-03-03 ORBIMED ADVISORS LLC Sale 526.0
2017-03-03 SILVERSTEIN JONATHAN Sale 55246.0
2017-03-03 SILVERSTEIN JONATHAN Sale 526.0
2017-03-10 ORBIMED ADVISORS LLC Sale 96113.0
2017-03-10 ORBIMED ADVISORS LLC Sale 915.0
2017-03-10 SILVERSTEIN JONATHAN Sale 96113.0
2017-03-10 SILVERSTEIN JONATHAN Sale 915.0
2017-03-13 ORBIMED ADVISORS LLC Sale 208712.0
2017-03-13 ORBIMED ADVISORS LLC Sale 1998.0
2017-03-13 ORBIMED ADVISORS LLC Sale 693.0
2017-03-13 ORBIMED ADVISORS LLC Sale 7.0
2017-03-13 SILVERSTEIN JONATHAN Sale 208712.0
2017-03-13 SILVERSTEIN JONATHAN Sale 1998.0
2017-03-13 SILVERSTEIN JONATHAN Sale 693.0
2017-03-13 SILVERSTEIN JONATHAN Sale 7.0
2017-03-14 ORBIMED ADVISORS LLC Sale 73401.0
2017-03-14 ORBIMED ADVISORS LLC Sale 699.0
2017-03-14 SILVERSTEIN JONATHAN Sale 73401.0
2017-03-14 SILVERSTEIN JONATHAN Sale 699.0
2017-08-15 ORBIMED ADVISORS LLC Sale 32193.0
2017-08-15 ORBIMED ADVISORS LLC Sale 307.0
2017-08-15 SILVERSTEIN JONATHAN Sale 32193.0
2017-08-15 SILVERSTEIN JONATHAN Sale 307.0
2017-08-16 ORBIMED ADVISORS LLC Sale 64961.0
2017-08-16 ORBIMED ADVISORS LLC Sale 619.0
2017-08-16 SILVERSTEIN JONATHAN Sale 64961.0
2017-08-16 SILVERSTEIN JONATHAN Sale 619.0
2017-08-17 ORBIMED ADVISORS LLC Sale 224780.0
2017-08-17 ORBIMED ADVISORS LLC Sale 2140.0
2017-08-17 SILVERSTEIN JONATHAN Sale 224780.0
2017-08-17 SILVERSTEIN JONATHAN Sale 2140.0
2017-08-31 SILVERSTEIN JONATHAN Sale 44498.0
2017-08-31 SILVERSTEIN JONATHAN Sale 424.0
2017-08-31 ORBIMED ADVISORS LLC Sale 44498.0
2017-08-31 ORBIMED ADVISORS LLC Sale 424.0
2017-09-01 SILVERSTEIN JONATHAN Sale 109040.0
2017-09-01 SILVERSTEIN JONATHAN Sale 1038.0
2017-09-01 ORBIMED ADVISORS LLC Sale 109040.0
2017-09-01 ORBIMED ADVISORS LLC Sale 1038.0
2017-09-05 SILVERSTEIN JONATHAN Sale 173349.0
2017-09-05 SILVERSTEIN JONATHAN Sale 1651.0
2017-09-05 SILVERSTEIN JONATHAN Sale 189792.0
2017-09-05 SILVERSTEIN JONATHAN Sale 1808.0
2017-09-05 SILVERSTEIN JONATHAN Sale 58047.0
2017-09-05 SILVERSTEIN JONATHAN Sale 553.0
2017-09-05 ORBIMED ADVISORS LLC Sale 173349.0
2017-09-05 ORBIMED ADVISORS LLC Sale 1651.0
2017-09-05 ORBIMED ADVISORS LLC Sale 189792.0
2017-09-05 ORBIMED ADVISORS LLC Sale 1808.0
2017-09-05 ORBIMED ADVISORS LLC Sale 58047.0
2017-09-05 ORBIMED ADVISORS LLC Sale 553.0
2017-09-05 Burns Thomas William Sale 1212.0
2017-09-07 Burns Thomas William Sale 73788.0
2017-11-22 Gilliam Joseph E Purchase 2100.0
2018-03-02 ORBIMED ADVISORS LLC Sale 265766.0
2018-03-02 ORBIMED ADVISORS LLC Sale 2533.0
2018-03-02 ORBIMED ADVISORS LLC Sale 194433.0
2018-03-02 ORBIMED ADVISORS LLC Sale 1851.0
2018-03-02 SILVERSTEIN JONATHAN Sale 265766.0
2018-03-02 SILVERSTEIN JONATHAN Sale 2533.0
2018-03-02 SILVERSTEIN JONATHAN Sale 194433.0
2018-03-02 SILVERSTEIN JONATHAN Sale 1851.0
2018-03-05 ORBIMED ADVISORS LLC Sale 128092.0
2018-03-05 ORBIMED ADVISORS LLC Sale 1220.0
2018-03-05 ORBIMED ADVISORS LLC Sale 80516.0
2018-03-05 ORBIMED ADVISORS LLC Sale 768.0
2018-03-05 SILVERSTEIN JONATHAN Sale 128092.0
2018-03-05 SILVERSTEIN JONATHAN Sale 1220.0
2018-03-05 SILVERSTEIN JONATHAN Sale 80516.0
2018-03-05 SILVERSTEIN JONATHAN Sale 768.0
2018-03-06 ORBIMED ADVISORS LLC Sale 93008.0
2018-03-06 ORBIMED ADVISORS LLC Sale 886.0
2018-03-06 ORBIMED ADVISORS LLC Sale 20114.0
2018-03-06 ORBIMED ADVISORS LLC Sale 192.0
2018-03-06 ORBIMED ADVISORS LLC Sale 46676.0
2018-03-06 ORBIMED ADVISORS LLC Sale 445.0
2018-03-06 SILVERSTEIN JONATHAN Sale 93008.0
2018-03-06 SILVERSTEIN JONATHAN Sale 886.0
2018-03-06 SILVERSTEIN JONATHAN Sale 20114.0
2018-03-06 SILVERSTEIN JONATHAN Sale 192.0
2018-03-06 SILVERSTEIN JONATHAN Sale 46676.0
2018-03-06 SILVERSTEIN JONATHAN Sale 445.0
2018-06-15 Calcaterra Chris M. Sale 8771.0
2018-06-19 Calcaterra Chris M. Sale 7759.0
2018-06-20 Calcaterra Chris M. Sale 2470.0
2018-08-02 Calcaterra Chris M. Sale 34361.0
2018-08-02 Calcaterra Chris M. Sale 4522.0
2018-08-02 Calcaterra Chris M. Sale 100.0
2018-08-06 Burns Thomas William Sale 19445.0
2018-08-06 Burns Thomas William Sale 45449.0
2018-08-06 Burns Thomas William Sale 33991.0
2018-08-07 Burns Thomas William Sale 39099.0
2018-08-07 Burns Thomas William Sale 12016.0
2018-08-29 Kliman Gilbert H Sale 500000.0
2018-08-30 Kliman Gilbert H Sale 2760.0
2018-11-13 LINK WILLIAM J PHD Sale 14475.0
2018-11-15 LINK WILLIAM J PHD Sale 25725.0
2018-11-15 LINK WILLIAM J PHD Sale 1300.0
2018-11-26 Gilliam Joseph E Sale 2100.0
2018-11-28 Gilliam Joseph E Sale 5000.0
2019-02-19 Gilliam Joseph E Sale 5000.0
2019-03-05 Calcaterra Chris M. Sale 46656.0
2019-03-05 Calcaterra Chris M. Sale 26740.0
2019-03-06 Calcaterra Chris M. Sale 11801.0
2019-03-06 Calcaterra Chris M. Sale 4076.0
2019-03-06 Calcaterra Chris M. Sale 727.0
2019-05-13 Gilliam Joseph E Sale 103.0
2019-05-13 Gilliam Joseph E Sale 2500.0
2019-05-16 Gilliam Joseph E Sale 3647.0
2019-06-12 Gilliam Joseph E Sale 2500.0
2019-06-17 Gilliam Joseph E Sale 4292.0
2019-06-17 Gilliam Joseph E Sale 1958.0
2019-06-17 Gilliam Joseph E Sale 1784.0
2019-06-17 Gilliam Joseph E Sale 716.0
2019-07-22 Gilliam Joseph E Sale 2294.0
2019-07-22 Gilliam Joseph E Sale 3956.0
2019-07-22 Gilliam Joseph E Sale 1556.0
2019-07-22 Gilliam Joseph E Sale 2540.0
2019-08-26 Gilliam Joseph E Sale 4631.0
2019-09-10 Gilliam Joseph E Sale 3750.0
2019-09-12 Gilliam Joseph E Sale 2500.0
2019-09-30 Gilliam Joseph E Sale 4631.0
2020-02-12 Gilliam Joseph E Sale 3750.0
2020-05-20 Burns Thomas William Sale 400.0
2020-05-26 Burns Thomas William Sale 193989.0
2020-05-26 Burns Thomas William Sale 13458.0
2020-12-01 LINK WILLIAM J PHD Sale 600
2020-12-01 LINK WILLIAM J PHD Sale 49400
2021-02-01 Calcaterra Chris M. Sale 16785
2021-02-01 Calcaterra Chris M. Sale 24401
2021-02-01 Calcaterra Chris M. Sale 6030
2021-02-01 Calcaterra Chris M. Sale 13201
2021-02-09 Gilliam Joseph E Sale 2262
2021-02-09 Gilliam Joseph E Sale 11488
Transaction Date) Insider Transaction Type Number of Shares Transacted