| Transaction Date | Insider | Transaction Type | Number of Shares Transacted |
|---|---|---|---|
| 2015-06-24 | MORE ROBERT J | Purchase | 5000.0 |
| 2015-11-12 | WEISNER AIMEE S | Purchase | 2500.0 |
| 2015-12-31 | HARRISON RICHARD L | Purchase | 1388.0 |
| 2015-12-31 | Burns Thomas William | Purchase | 1388.0 |
| 2016-02-25 | MONTREUX EQUITY PARTNERS IV LP | Sale | 70000.0 |
| 2016-03-04 | WEISNER AIMEE S | Purchase | 2500.0 |
| 2016-05-03 | Calcaterra Chris M. | Sale | 700.0 |
| 2016-05-03 | HARRISON RICHARD L | Sale | 1100.0 |
| 2016-05-03 | Burns Thomas William | Sale | 800.0 |
| 2016-05-04 | Calcaterra Chris M. | Sale | 4383.0 |
| 2016-05-04 | Calcaterra Chris M. | Sale | 1453.0 |
| 2016-05-04 | Calcaterra Chris M. | Sale | 51115.0 |
| 2016-05-04 | Calcaterra Chris M. | Sale | 16885.0 |
| 2016-05-04 | HARRISON RICHARD L | Sale | 2031.0 |
| 2016-05-04 | HARRISON RICHARD L | Sale | 137.0 |
| 2016-05-04 | HARRISON RICHARD L | Sale | 25069.0 |
| 2016-05-04 | HARRISON RICHARD L | Sale | 1663.0 |
| 2016-05-04 | Burns Thomas William | Sale | 34100.0 |
| 2016-05-04 | Burns Thomas William | Sale | 1800.0 |
| 2016-05-25 | Burns Thomas William | Sale | 300.0 |
| 2016-05-31 | VERSANT VENTURES I LLC | Sale | 10970.0 |
| 2016-05-31 | VERSANT VENTURES I LLC | Sale | 23088.0 |
| 2016-05-31 | VERSANT VENTURES I LLC | Sale | 10970.0 |
| 2016-05-31 | VERSANT VENTURES I LLC | Sale | 23088.0 |
| 2016-05-31 | LINK WILLIAM J PHD | Sale | 10970.0 |
| 2016-05-31 | LINK WILLIAM J PHD | Sale | 23088.0 |
| 2016-06-01 | Burns Thomas William | Sale | 25000.0 |
| 2016-06-03 | Burns Thomas William | Sale | 422.0 |
| 2016-06-06 | Burns Thomas William | Sale | 24578.0 |
| 2016-06-15 | Calcaterra Chris M. | Sale | 45464.0 |
| 2016-06-20 | HARRISON RICHARD L | Sale | 4300.0 |
| 2016-06-20 | Burns Thomas William | Sale | 7997.0 |
| 2016-07-01 | Burns Thomas William | Sale | 50000.0 |
| 2016-07-12 | HARRISON RICHARD L | Sale | 5700.0 |
| 2016-07-12 | Burns Thomas William | Sale | 10500.0 |
| 2016-07-13 | Burns Thomas William | Sale | 151754.0 |
| 2016-07-27 | HARRISON RICHARD L | Sale | 10000.0 |
| 2016-08-03 | ORBIMED ADVISORS LLC | Sale | 420990.0 |
| 2016-08-03 | ORBIMED ADVISORS LLC | Sale | 4010.0 |
| 2016-08-03 | SILVERSTEIN JONATHAN | Sale | 420990.0 |
| 2016-08-03 | SILVERSTEIN JONATHAN | Sale | 4010.0 |
| 2016-08-10 | SILVERSTEIN JONATHAN | Sale | 116825.0 |
| 2016-08-10 | SILVERSTEIN JONATHAN | Sale | 1113.0 |
| 2016-08-10 | ORBIMED ADVISORS LLC | Sale | 116825.0 |
| 2016-08-10 | ORBIMED ADVISORS LLC | Sale | 1113.0 |
| 2016-08-11 | SILVERSTEIN JONATHAN | Sale | 159382.0 |
| 2016-08-11 | SILVERSTEIN JONATHAN | Sale | 1518.0 |
| 2016-08-11 | ORBIMED ADVISORS LLC | Sale | 159382.0 |
| 2016-08-11 | ORBIMED ADVISORS LLC | Sale | 1518.0 |
| 2016-08-12 | SILVERSTEIN JONATHAN | Sale | 13967.0 |
| 2016-08-12 | SILVERSTEIN JONATHAN | Sale | 133.0 |
| 2016-08-12 | ORBIMED ADVISORS LLC | Sale | 13967.0 |
| 2016-08-12 | ORBIMED ADVISORS LLC | Sale | 133.0 |
| 2016-10-20 | Calcaterra Chris M. | Sale | 37000.0 |
| 2016-10-20 | Calcaterra Chris M. | Sale | 3000.0 |
| 2016-10-24 | Calcaterra Chris M. | Sale | 20000.0 |
| 2016-11-14 | Burns Thomas William | Sale | 186515.0 |
| 2016-11-14 | Burns Thomas William | Sale | 3605.0 |
| 2016-11-15 | Burns Thomas William | Sale | 10000.0 |
| 2016-11-17 | LINK WILLIAM J PHD | Sale | 30000.0 |
| 2017-01-06 | HARRISON RICHARD L | Sale | 20574.0 |
| 2017-01-06 | HARRISON RICHARD L | Sale | 60.0 |
| 2017-01-09 | Calcaterra Chris M. | Sale | 20000.0 |
| 2017-01-09 | Burns Thomas William | Sale | 40000.0 |
| 2017-01-12 | Calcaterra Chris M. | Sale | 14413.0 |
| 2017-01-12 | HARRISON RICHARD L | Sale | 14321.0 |
| 2017-01-13 | Calcaterra Chris M. | Sale | 3723.0 |
| 2017-01-13 | HARRISON RICHARD L | Sale | 6313.0 |
| 2017-02-02 | Burns Thomas William | Sale | 50000.0 |
| 2017-03-03 | ORBIMED ADVISORS LLC | Sale | 55246.0 |
| 2017-03-03 | ORBIMED ADVISORS LLC | Sale | 526.0 |
| 2017-03-03 | SILVERSTEIN JONATHAN | Sale | 55246.0 |
| 2017-03-03 | SILVERSTEIN JONATHAN | Sale | 526.0 |
| 2017-03-10 | ORBIMED ADVISORS LLC | Sale | 96113.0 |
| 2017-03-10 | ORBIMED ADVISORS LLC | Sale | 915.0 |
| 2017-03-10 | SILVERSTEIN JONATHAN | Sale | 96113.0 |
| 2017-03-10 | SILVERSTEIN JONATHAN | Sale | 915.0 |
| 2017-03-13 | ORBIMED ADVISORS LLC | Sale | 208712.0 |
| 2017-03-13 | ORBIMED ADVISORS LLC | Sale | 1998.0 |
| 2017-03-13 | ORBIMED ADVISORS LLC | Sale | 693.0 |
| 2017-03-13 | ORBIMED ADVISORS LLC | Sale | 7.0 |
| 2017-03-13 | SILVERSTEIN JONATHAN | Sale | 208712.0 |
| 2017-03-13 | SILVERSTEIN JONATHAN | Sale | 1998.0 |
| 2017-03-13 | SILVERSTEIN JONATHAN | Sale | 693.0 |
| 2017-03-13 | SILVERSTEIN JONATHAN | Sale | 7.0 |
| 2017-03-14 | ORBIMED ADVISORS LLC | Sale | 73401.0 |
| 2017-03-14 | ORBIMED ADVISORS LLC | Sale | 699.0 |
| 2017-03-14 | SILVERSTEIN JONATHAN | Sale | 73401.0 |
| 2017-03-14 | SILVERSTEIN JONATHAN | Sale | 699.0 |
| 2017-08-15 | ORBIMED ADVISORS LLC | Sale | 32193.0 |
| 2017-08-15 | ORBIMED ADVISORS LLC | Sale | 307.0 |
| 2017-08-15 | SILVERSTEIN JONATHAN | Sale | 32193.0 |
| 2017-08-15 | SILVERSTEIN JONATHAN | Sale | 307.0 |
| 2017-08-16 | ORBIMED ADVISORS LLC | Sale | 64961.0 |
| 2017-08-16 | ORBIMED ADVISORS LLC | Sale | 619.0 |
| 2017-08-16 | SILVERSTEIN JONATHAN | Sale | 64961.0 |
| 2017-08-16 | SILVERSTEIN JONATHAN | Sale | 619.0 |
| 2017-08-17 | ORBIMED ADVISORS LLC | Sale | 224780.0 |
| 2017-08-17 | ORBIMED ADVISORS LLC | Sale | 2140.0 |
| 2017-08-17 | SILVERSTEIN JONATHAN | Sale | 224780.0 |
| 2017-08-17 | SILVERSTEIN JONATHAN | Sale | 2140.0 |
| 2017-08-31 | SILVERSTEIN JONATHAN | Sale | 44498.0 |
| 2017-08-31 | SILVERSTEIN JONATHAN | Sale | 424.0 |
| 2017-08-31 | ORBIMED ADVISORS LLC | Sale | 44498.0 |
| 2017-08-31 | ORBIMED ADVISORS LLC | Sale | 424.0 |
| 2017-09-01 | SILVERSTEIN JONATHAN | Sale | 109040.0 |
| 2017-09-01 | SILVERSTEIN JONATHAN | Sale | 1038.0 |
| 2017-09-01 | ORBIMED ADVISORS LLC | Sale | 109040.0 |
| 2017-09-01 | ORBIMED ADVISORS LLC | Sale | 1038.0 |
| 2017-09-05 | SILVERSTEIN JONATHAN | Sale | 173349.0 |
| 2017-09-05 | SILVERSTEIN JONATHAN | Sale | 1651.0 |
| 2017-09-05 | SILVERSTEIN JONATHAN | Sale | 189792.0 |
| 2017-09-05 | SILVERSTEIN JONATHAN | Sale | 1808.0 |
| 2017-09-05 | SILVERSTEIN JONATHAN | Sale | 58047.0 |
| 2017-09-05 | SILVERSTEIN JONATHAN | Sale | 553.0 |
| 2017-09-05 | ORBIMED ADVISORS LLC | Sale | 173349.0 |
| 2017-09-05 | ORBIMED ADVISORS LLC | Sale | 1651.0 |
| 2017-09-05 | ORBIMED ADVISORS LLC | Sale | 189792.0 |
| 2017-09-05 | ORBIMED ADVISORS LLC | Sale | 1808.0 |
| 2017-09-05 | ORBIMED ADVISORS LLC | Sale | 58047.0 |
| 2017-09-05 | ORBIMED ADVISORS LLC | Sale | 553.0 |
| 2017-09-05 | Burns Thomas William | Sale | 1212.0 |
| 2017-09-07 | Burns Thomas William | Sale | 73788.0 |
| 2017-11-22 | Gilliam Joseph E | Purchase | 2100.0 |
| 2018-03-02 | ORBIMED ADVISORS LLC | Sale | 265766.0 |
| 2018-03-02 | ORBIMED ADVISORS LLC | Sale | 2533.0 |
| 2018-03-02 | ORBIMED ADVISORS LLC | Sale | 194433.0 |
| 2018-03-02 | ORBIMED ADVISORS LLC | Sale | 1851.0 |
| 2018-03-02 | SILVERSTEIN JONATHAN | Sale | 265766.0 |
| 2018-03-02 | SILVERSTEIN JONATHAN | Sale | 2533.0 |
| 2018-03-02 | SILVERSTEIN JONATHAN | Sale | 194433.0 |
| 2018-03-02 | SILVERSTEIN JONATHAN | Sale | 1851.0 |
| 2018-03-05 | ORBIMED ADVISORS LLC | Sale | 128092.0 |
| 2018-03-05 | ORBIMED ADVISORS LLC | Sale | 1220.0 |
| 2018-03-05 | ORBIMED ADVISORS LLC | Sale | 80516.0 |
| 2018-03-05 | ORBIMED ADVISORS LLC | Sale | 768.0 |
| 2018-03-05 | SILVERSTEIN JONATHAN | Sale | 128092.0 |
| 2018-03-05 | SILVERSTEIN JONATHAN | Sale | 1220.0 |
| 2018-03-05 | SILVERSTEIN JONATHAN | Sale | 80516.0 |
| 2018-03-05 | SILVERSTEIN JONATHAN | Sale | 768.0 |
| 2018-03-06 | ORBIMED ADVISORS LLC | Sale | 93008.0 |
| 2018-03-06 | ORBIMED ADVISORS LLC | Sale | 886.0 |
| 2018-03-06 | ORBIMED ADVISORS LLC | Sale | 20114.0 |
| 2018-03-06 | ORBIMED ADVISORS LLC | Sale | 192.0 |
| 2018-03-06 | ORBIMED ADVISORS LLC | Sale | 46676.0 |
| 2018-03-06 | ORBIMED ADVISORS LLC | Sale | 445.0 |
| 2018-03-06 | SILVERSTEIN JONATHAN | Sale | 93008.0 |
| 2018-03-06 | SILVERSTEIN JONATHAN | Sale | 886.0 |
| 2018-03-06 | SILVERSTEIN JONATHAN | Sale | 20114.0 |
| 2018-03-06 | SILVERSTEIN JONATHAN | Sale | 192.0 |
| 2018-03-06 | SILVERSTEIN JONATHAN | Sale | 46676.0 |
| 2018-03-06 | SILVERSTEIN JONATHAN | Sale | 445.0 |
| 2018-06-15 | Calcaterra Chris M. | Sale | 8771.0 |
| 2018-06-19 | Calcaterra Chris M. | Sale | 7759.0 |
| 2018-06-20 | Calcaterra Chris M. | Sale | 2470.0 |
| 2018-08-02 | Calcaterra Chris M. | Sale | 34361.0 |
| 2018-08-02 | Calcaterra Chris M. | Sale | 4522.0 |
| 2018-08-02 | Calcaterra Chris M. | Sale | 100.0 |
| 2018-08-06 | Burns Thomas William | Sale | 19445.0 |
| 2018-08-06 | Burns Thomas William | Sale | 45449.0 |
| 2018-08-06 | Burns Thomas William | Sale | 33991.0 |
| 2018-08-07 | Burns Thomas William | Sale | 39099.0 |
| 2018-08-07 | Burns Thomas William | Sale | 12016.0 |
| 2018-08-29 | Kliman Gilbert H | Sale | 500000.0 |
| 2018-08-30 | Kliman Gilbert H | Sale | 2760.0 |
| 2018-11-13 | LINK WILLIAM J PHD | Sale | 14475.0 |
| 2018-11-15 | LINK WILLIAM J PHD | Sale | 25725.0 |
| 2018-11-15 | LINK WILLIAM J PHD | Sale | 1300.0 |
| 2018-11-26 | Gilliam Joseph E | Sale | 2100.0 |
| 2018-11-28 | Gilliam Joseph E | Sale | 5000.0 |
| 2019-02-19 | Gilliam Joseph E | Sale | 5000.0 |
| 2019-03-05 | Calcaterra Chris M. | Sale | 46656.0 |
| 2019-03-05 | Calcaterra Chris M. | Sale | 26740.0 |
| 2019-03-06 | Calcaterra Chris M. | Sale | 11801.0 |
| 2019-03-06 | Calcaterra Chris M. | Sale | 4076.0 |
| 2019-03-06 | Calcaterra Chris M. | Sale | 727.0 |
| 2019-05-13 | Gilliam Joseph E | Sale | 103.0 |
| 2019-05-13 | Gilliam Joseph E | Sale | 2500.0 |
| 2019-05-16 | Gilliam Joseph E | Sale | 3647.0 |
| 2019-06-12 | Gilliam Joseph E | Sale | 2500.0 |
| 2019-06-17 | Gilliam Joseph E | Sale | 4292.0 |
| 2019-06-17 | Gilliam Joseph E | Sale | 1958.0 |
| 2019-06-17 | Gilliam Joseph E | Sale | 1784.0 |
| 2019-06-17 | Gilliam Joseph E | Sale | 716.0 |
| 2019-07-22 | Gilliam Joseph E | Sale | 2294.0 |
| 2019-07-22 | Gilliam Joseph E | Sale | 3956.0 |
| 2019-07-22 | Gilliam Joseph E | Sale | 1556.0 |
| 2019-07-22 | Gilliam Joseph E | Sale | 2540.0 |
| 2019-08-26 | Gilliam Joseph E | Sale | 4631.0 |
| 2019-09-10 | Gilliam Joseph E | Sale | 3750.0 |
| 2019-09-12 | Gilliam Joseph E | Sale | 2500.0 |
| 2019-09-30 | Gilliam Joseph E | Sale | 4631.0 |
| 2020-02-12 | Gilliam Joseph E | Sale | 3750.0 |
| 2020-05-20 | Burns Thomas William | Sale | 400.0 |
| 2020-05-26 | Burns Thomas William | Sale | 193989.0 |
| 2020-05-26 | Burns Thomas William | Sale | 13458.0 |
| 2020-12-01 | LINK WILLIAM J PHD | Sale | 600 |
| 2020-12-01 | LINK WILLIAM J PHD | Sale | 49400 |
| 2021-02-01 | Calcaterra Chris M. | Sale | 16785 |
| 2021-02-01 | Calcaterra Chris M. | Sale | 24401 |
| 2021-02-01 | Calcaterra Chris M. | Sale | 6030 |
| 2021-02-01 | Calcaterra Chris M. | Sale | 13201 |
| 2021-02-09 | Gilliam Joseph E | Sale | 2262 |
| 2021-02-09 | Gilliam Joseph E | Sale | 11488 |
| Transaction Date) | Insider | Transaction Type | Number of Shares Transacted |