| Transaction Date | Insider | Transaction Type | Number of Shares Transacted |
|---|---|---|---|
| 2015-02-23 | MedImmune Ventures, Inc. | Purchase | 416667.0 |
| 2015-02-23 | DEVON PARK BIOVENTURES LP | Purchase | 814166.0 |
| 2015-02-23 | Kantesaria Devang | Purchase | 814166.0 |
| 2015-02-23 | RHO VENTURES IV QP LP | Purchase | 958226.0 |
| 2015-02-23 | CARE CAPITAL II LLC | Purchase | 603832.0 |
| 2015-02-23 | KARABELAS ARGERIS N | Purchase | 603832.0 |
| 2015-02-23 | Pitango Venture Capital Principals Fund IV, L.P. | Purchase | 212375.0 |
| 2016-05-13 | CARROLL J MARTIN | Purchase | 10000.0 |
| 2017-01-06 | SOUTHWELL DAVID P | Purchase | 60000.0 |
| 2018-08-01 | Yalamanchi Naveen | Sale | 637.0 |
| 2018-12-06 | Patel Kinnari | Purchase | 5675.0 |
| 2018-12-06 | SOUTHWELL DAVID P | Sale | 52809.0 |
| 2018-12-07 | SOUTHWELL DAVID P | Sale | 4923.0 |
| 2018-12-13 | SOUTHWELL DAVID P | Sale | 38768.0 |
| 2019-03-01 | Shah Gaurav | Sale | 25000.0 |
| 2019-03-04 | Shah Gaurav | Sale | 24900.0 |
| 2019-03-05 | Shah Gaurav | Sale | 25000.0 |
| 2019-04-16 | RTW INVESTMENTS, LP | Purchase | 550005.0 |
| 2019-12-10 | RTW INVESTMENTS, LP | Purchase | 225000.0 |
| 2020-03-18 | Patel Kinnari | Purchase | 1000.0 |
| 2020-12-10 | RTW INVESTMENTS, LP | Purchase | 247720 |
| 2020-12-28 | Patel Kinnari | Sale | 5427 |
| 2020-12-28 | Patel Kinnari | Sale | 11334 |
| Transaction Date) | Insider | Transaction Type | Number of Shares Transacted |