| Transaction Date | Insider | Transaction Type | Number of Shares Transacted |
|---|---|---|---|
| 2018-10-09 | PROFUSEK ROBERT | Purchase | 10000.0 |
| 2018-10-09 | BAKER BROS. ADVISORS LP | Purchase | 251898.0 |
| 2018-10-09 | BAKER BROS. ADVISORS LP | Purchase | 2248102.0 |
| 2019-12-06 | BAKER BROS. ADVISORS LP | Purchase | 158180.0 |
| 2019-12-06 | BAKER BROS. ADVISORS LP | Purchase | 1743993.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 164.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 1813.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 8.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 92.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 912.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 10121.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 523.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 5804.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 1921.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 21301.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 323.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 3577.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 642.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 7122.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 612.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 6788.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 777.0 |
| 2020-02-24 | BAKER BROS. ADVISORS LP | Purchase | 8623.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 1298.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 14402.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 1267.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 14051.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 13164.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 145994.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 1319.0 |
| 2020-02-25 | BAKER BROS. ADVISORS LP | Purchase | 14631.0 |
| 2020-02-26 | BAKER BROS. ADVISORS LP | Purchase | 811.0 |
| 2020-02-26 | BAKER BROS. ADVISORS LP | Purchase | 8989.0 |
| 2020-02-26 | BAKER BROS. ADVISORS LP | Purchase | 7460.0 |
| 2020-02-26 | BAKER BROS. ADVISORS LP | Purchase | 82740.0 |
| 2020-03-16 | BAKER BROS. ADVISORS LP | Purchase | 8666.0 |
| 2020-03-16 | BAKER BROS. ADVISORS LP | Purchase | 95934.0 |
| 2020-03-17 | BAKER BROS. ADVISORS LP | Purchase | 828.0 |
| 2020-03-17 | BAKER BROS. ADVISORS LP | Purchase | 9172.0 |
| 2020-03-18 | BAKER BROS. ADVISORS LP | Purchase | 1542.0 |
| 2020-03-18 | BAKER BROS. ADVISORS LP | Purchase | 17058.0 |
| 2020-03-18 | BAKER BROS. ADVISORS LP | Purchase | 563.0 |
| 2020-03-18 | BAKER BROS. ADVISORS LP | Purchase | 6237.0 |
| 2020-03-18 | BAKER BROS. ADVISORS LP | Purchase | 828.0 |
| 2020-03-18 | BAKER BROS. ADVISORS LP | Purchase | 9172.0 |
| 2020-03-19 | Liang Hong | Sale | 1954.0 |
| 2020-03-19 | Liang Hong | Sale | 2046.0 |
| 2020-03-20 | EHRLICH JASON | Sale | 233.0 |
| 2020-03-20 | EHRLICH JASON | Sale | 1458.0 |
| 2020-03-20 | EHRLICH JASON | Sale | 2120.0 |
| 2020-03-20 | EHRLICH JASON | Sale | 750.0 |
| 2020-03-20 | EHRLICH JASON | Sale | 1917.0 |
| 2020-03-20 | EHRLICH JASON | Sale | 344.0 |
| 2020-03-20 | EHRLICH JASON | Sale | 128.0 |
| 2020-03-20 | Levy Richard S | Purchase | 250.0 |
| 2020-03-20 | Levy Richard S | Purchase | 750.0 |
| 2020-03-26 | Liang Hong | Sale | 2545.0 |
| 2020-03-26 | Liang Hong | Sale | 1103.0 |
| 2020-03-26 | Liang Hong | Sale | 352.0 |
| 2020-04-02 | Liang Hong | Sale | 4000.0 |
| 2020-04-09 | EHRLICH JASON | Sale | 938.0 |
| 2020-04-09 | EHRLICH JASON | Sale | 345.0 |
| 2020-04-09 | EHRLICH JASON | Sale | 917.0 |
| 2020-04-20 | EHRLICH JASON | Sale | 1639.0 |
| 2020-04-20 | EHRLICH JASON | Sale | 551.0 |
| 2020-04-20 | EHRLICH JASON | Sale | 2836.0 |
| 2020-04-20 | EHRLICH JASON | Sale | 1924.0 |
| 2020-05-20 | EHRLICH JASON | Sale | 1229.0 |
| 2020-05-20 | EHRLICH JASON | Sale | 3631.0 |
| 2020-05-20 | EHRLICH JASON | Sale | 2090.0 |
| 2020-06-22 | EHRLICH JASON | Sale | 2792.0 |
| 2020-06-22 | EHRLICH JASON | Sale | 1684.0 |
| 2020-06-22 | EHRLICH JASON | Sale | 1645.0 |
| 2020-06-22 | EHRLICH JASON | Sale | 723.0 |
| 2020-06-22 | EHRLICH JASON | Sale | 106.0 |
| 2020-07-20 | EHRLICH JASON | Sale | 1474.0 |
| 2020-07-20 | EHRLICH JASON | Sale | 5100.0 |
| 2020-07-20 | EHRLICH JASON | Sale | 376.0 |
| 2020-08-19 | BAKER BROS. ADVISORS LP | Purchase | 284.0 |
| 2020-08-19 | BAKER BROS. ADVISORS LP | Purchase | 3585.0 |
| 2020-08-20 | EHRLICH JASON | Sale | 2591.0 |
| 2020-08-20 | EHRLICH JASON | Sale | 4359.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 283.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 3576.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 843.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 10640.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 3262.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 41155.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 60.0 |
| 2020-08-20 | BAKER BROS. ADVISORS LP | Purchase | 754.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 3386.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 42714.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 181.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 2286.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 6645.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 83832.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 185.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 2359.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 234.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 2987.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 6062.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 77456.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 2512.0 |
| 2020-09-03 | BAKER BROS. ADVISORS LP | Purchase | 32088.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 950.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 12132.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 2295.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 29319.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 2054.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 26238.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 712.0 |
| 2020-09-04 | BAKER BROS. ADVISORS LP | Purchase | 9101.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 15.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 185.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 1272.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 15807.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 6151.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 76473.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 1220.0 |
| 2020-09-08 | BAKER BROS. ADVISORS LP | Purchase | 15172.0 |
| 2020-09-21 | EHRLICH JASON | Sale | 3314.0 |
| 2020-09-21 | EHRLICH JASON | Sale | 1975.0 |
| 2020-09-21 | EHRLICH JASON | Sale | 1097.0 |
| 2020-09-21 | EHRLICH JASON | Sale | 545.0 |
| 2020-09-21 | EHRLICH JASON | Sale | 19.0 |
| 2020-09-22 | BAKER BROS. ADVISORS LP | Purchase | 779.0 |
| 2020-09-22 | BAKER BROS. ADVISORS LP | Purchase | 10983.0 |
| 2020-09-22 | BAKER BROS. ADVISORS LP | Purchase | 2601.0 |
| 2020-09-22 | BAKER BROS. ADVISORS LP | Purchase | 36647.0 |
| 2020-09-22 | BAKER BROS. ADVISORS LP | Purchase | 1587.0 |
| 2020-09-22 | BAKER BROS. ADVISORS LP | Purchase | 22361.0 |
| 2020-09-23 | BAKER BROS. ADVISORS LP | Purchase | 80.0 |
| 2020-09-23 | BAKER BROS. ADVISORS LP | Purchase | 1120.0 |
| 2020-09-23 | BAKER BROS. ADVISORS LP | Purchase | 743.0 |
| 2020-09-23 | BAKER BROS. ADVISORS LP | Purchase | 10467.0 |
| 2020-09-23 | BAKER BROS. ADVISORS LP | Purchase | 5278.0 |
| 2020-09-23 | BAKER BROS. ADVISORS LP | Purchase | 74381.0 |
| 2020-09-24 | BAKER BROS. ADVISORS LP | Purchase | 306.0 |
| 2020-09-24 | BAKER BROS. ADVISORS LP | Purchase | 4306.0 |
| 2020-09-24 | BAKER BROS. ADVISORS LP | Purchase | 2081.0 |
| 2020-09-24 | BAKER BROS. ADVISORS LP | Purchase | 29327.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 933.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 13153.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 334.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 4705.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 1365.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 19235.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 557.0 |
| 2020-09-25 | BAKER BROS. ADVISORS LP | Purchase | 7843.0 |
| 2020-10-09 | EHRLICH JASON | Sale | 553.0 |
| 2020-10-09 | EHRLICH JASON | Sale | 751.0 |
| 2020-10-09 | EHRLICH JASON | Sale | 896.0 |
| 2020-10-13 | EHRLICH JASON | Sale | 5000.0 |
| 2020-10-20 | EHRLICH JASON | Sale | 339.0 |
| 2020-10-20 | EHRLICH JASON | Sale | 3397.0 |
| 2020-10-20 | EHRLICH JASON | Sale | 3214.0 |
| 2020-10-23 | EHRLICH JASON | Sale | 7500.0 |
| 2020-10-27 | EHRLICH JASON | Sale | 7500.0 |
| 2020-11-20 | EHRLICH JASON | Sale | 57 |
| 2020-11-20 | EHRLICH JASON | Sale | 2614 |
| 2020-11-20 | EHRLICH JASON | Sale | 2134 |
| 2020-11-20 | EHRLICH JASON | Sale | 981 |
| 2020-11-20 | EHRLICH JASON | Sale | 400 |
| 2020-11-20 | EHRLICH JASON | Sale | 259 |
| 2020-11-20 | EHRLICH JASON | Sale | 505 |
| 2020-11-20 | BAKER BROS. ADVISORS LP | Purchase | 1411619 |
| 2020-11-20 | BAKER BROS. ADVISORS LP | Purchase | 116158 |
| 2020-12-21 | EHRLICH JASON | Sale | 82 |
| 2020-12-21 | EHRLICH JASON | Sale | 299 |
| 2020-12-21 | EHRLICH JASON | Sale | 1096 |
| 2020-12-21 | EHRLICH JASON | Sale | 1434 |
| 2020-12-21 | EHRLICH JASON | Sale | 809 |
| 2020-12-21 | EHRLICH JASON | Sale | 408 |
| 2020-12-21 | EHRLICH JASON | Sale | 556 |
| 2020-12-21 | EHRLICH JASON | Sale | 863 |
| 2020-12-21 | EHRLICH JASON | Sale | 1016 |
| 2020-12-21 | EHRLICH JASON | Sale | 387 |
| 2021-01-20 | EHRLICH JASON | Sale | 1335 |
| 2021-01-20 | EHRLICH JASON | Sale | 3097 |
| 2021-01-20 | EHRLICH JASON | Sale | 3132 |
| 2021-01-20 | EHRLICH JASON | Sale | 1497 |
| 2021-01-20 | EHRLICH JASON | Sale | 2061 |
| 2021-01-20 | EHRLICH JASON | Sale | 4956 |
| 2021-01-20 | EHRLICH JASON | Sale | 4204 |
| 2021-01-20 | EHRLICH JASON | Sale | 6668 |
| 2021-02-22 | EHRLICH JASON | Sale | 413 |
| 2021-02-22 | EHRLICH JASON | Sale | 1827 |
| 2021-02-22 | EHRLICH JASON | Sale | 1611 |
| 2021-02-22 | EHRLICH JASON | Sale | 2150 |
| 2021-02-22 | EHRLICH JASON | Sale | 687 |
| 2021-02-22 | EHRLICH JASON | Sale | 262 |
| Transaction Date) | Insider | Transaction Type | Number of Shares Transacted |