Transaction Date Insider Transaction Type Number of Shares Transacted
2013-09-19 TANG CAPITAL PARTNERS LP Sale 32582.0
2013-09-20 TANG CAPITAL PARTNERS LP Sale 4316.0
2013-10-24 BAKER FELIX Purchase 44314.0
2013-10-24 BAKER FELIX Purchase 346965.0
2013-10-24 BAKER FELIX Purchase 8721.0
2013-10-24 Boxer Capital, LLC Purchase 360000.0
2013-10-24 Boxer Capital, LLC Purchase 40000.0
2013-10-24 TANG CAPITAL PARTNERS LP Purchase 57143.0
2013-10-29 ORBIMED ADVISORS LLC Purchase 125000.0
2013-11-26 BAUM CHARLES M Purchase 5000.0
2014-06-27 ORBIMED ADVISORS LLC Sale 79120.0
2014-06-27 ORBIMED ADVISORS LLC Sale 9212.0
2014-06-30 ORBIMED ADVISORS LLC Sale 9283.0
2014-06-30 ORBIMED ADVISORS LLC Sale 4717.0
2014-07-01 ORBIMED ADVISORS LLC Sale 5000.0
2015-01-29 BAKER BROS. ADVISORS LP Purchase 34065.0
2015-01-29 BAKER BROS. ADVISORS LP Purchase 390935.0
2015-01-29 Boxer Capital, LLC Purchase 50000.0
2015-01-29 Boxer Capital, LLC Purchase 500000.0
2015-02-03 ORBIMED ADVISORS LLC Purchase 100000.0
2015-02-17 Christensen Jamie Sale 1250.0
2015-02-17 Christensen Jamie Sale 400.0
2015-02-19 Christensen Jamie Sale 3100.0
2015-03-05 Christensen Jamie Sale 4000.0
2015-03-05 Christensen Jamie Sale 2000.0
2015-05-26 Christensen Jamie Sale 2200.0
2015-05-26 Christensen Jamie Sale 2550.0
2015-09-16 Boxer Capital, LLC Purchase 22500.0
2015-09-16 Boxer Capital, LLC Purchase 22500.0
2015-09-16 BAKER BROS. ADVISORS LP Purchase 10780.0
2015-09-16 BAKER BROS. ADVISORS LP Purchase 139220.0
2015-09-17 Boxer Capital, LLC Sale 1.0
2015-09-17 Boxer Capital, LLC Sale 1.0
2016-01-15 Gergen Mark J Sale 10000.0
2016-03-18 Braslyn Ltd. Purchase 1166.0
2016-03-24 Braslyn Ltd. Purchase 20548.0
2016-03-28 Braslyn Ltd. Purchase 300.0
2016-03-29 Braslyn Ltd. Purchase 3400.0
2016-05-05 Braslyn Ltd. Purchase 61282.0
2016-05-06 Braslyn Ltd. Purchase 4500.0
2016-06-06 Braslyn Ltd. Purchase 215151.0
2016-06-07 Braslyn Ltd. Purchase 161751.0
2016-06-07 BAKER BROS. ADVISORS LP Sale 16493.0
2016-06-07 BAKER BROS. ADVISORS LP Sale 275506.0
2016-06-07 BAKER BROS. ADVISORS LP Sale 4201.0
2016-06-08 BAKER BROS. ADVISORS LP Sale 8417.0
2016-06-08 BAKER BROS. ADVISORS LP Sale 147529.0
2016-06-08 BAKER BROS. ADVISORS LP Sale 2154.0
2016-06-09 BAKER BROS. ADVISORS LP Sale 19970.0
2016-06-09 BAKER BROS. ADVISORS LP Sale 349919.0
2016-06-09 BAKER BROS. ADVISORS LP Sale 5111.0
2016-06-09 BAKER BROS. ADVISORS LP Sale 9056.0
2016-06-09 BAKER BROS. ADVISORS LP Sale 158684.0
2016-06-09 BAKER BROS. ADVISORS LP Sale 2318.0
2016-06-14 BAUM CHARLES M Purchase 20000.0
2017-01-06 Boxer Capital, LLC Purchase 280059.0
2017-01-06 Boxer Capital, LLC Purchase 6104.0
2017-01-06 Boxer Capital, LLC Purchase 2341786.0
2017-01-06 Boxer Capital, LLC Purchase 51047.0
2017-01-06 Braslyn Ltd. Purchase 581870.0
2017-01-06 Braslyn Ltd. Purchase 4865430.0
2017-01-12 Braslyn Ltd. Purchase 49776.0
2017-01-13 Braslyn Ltd. Purchase 52311.0
2017-01-17 Braslyn Ltd. Purchase 17800.0
2017-01-18 Braslyn Ltd. Purchase 16200.0
2017-01-19 Braslyn Ltd. Purchase 21085.0
2017-01-20 Braslyn Ltd. Purchase 23873.0
2017-01-23 Braslyn Ltd. Purchase 19251.0
2017-01-24 Braslyn Ltd. Purchase 27682.0
2017-01-25 Braslyn Ltd. Purchase 30600.0
2017-01-26 Braslyn Ltd. Purchase 19330.0
2017-01-26 Braslyn Ltd. Purchase 28839.0
2017-09-15 Christensen Jamie Sale 770.0
2017-09-21 Tuesday Thirteen Inc. Sale 1000.0
2017-10-04 Christensen Jamie Sale 4000.0
2017-11-02 Christensen Jamie Sale 7499.0
2017-11-16 Boxer Capital, LLC Purchase 144736.0
2017-11-16 Boxer Capital, LLC Purchase 255264.0
2017-11-16 Boxer Capital, LLC Purchase 801448.0
2017-11-16 Boxer Capital, LLC Purchase 1413475.0
2017-11-16 venBio Select Advisor LLC Purchase 650000.0
2017-11-16 Broadfin Healthcare Master Fund Ltd Sale 60000.0
2017-11-16 Christensen Jamie Sale 10275.0
2017-11-16 BAKER BROS. ADVISORS LP Purchase 304392.0
2017-11-16 BAKER BROS. ADVISORS LP Purchase 1618684.0
2018-01-11 Christensen Jamie Sale 225.0
2018-01-11 Christensen Jamie Sale 14500.0
2018-01-16 Christensen Jamie Sale 10814.0
2018-01-26 Christensen Jamie Sale 12500.0
2018-02-06 Christensen Jamie Sale 23000.0
2018-02-23 BAUM CHARLES M Sale 40748.0
2018-02-23 BAUM CHARLES M Sale 11062.0
2018-03-01 Donadio Jamie A Sale 25600.0
2018-03-01 Donadio Jamie A Sale 25775.0
2018-03-01 Donadio Jamie A Sale 500.0
2018-03-09 Donadio Jamie A Sale 12100.0
2018-03-09 Christensen Jamie Sale 22000.0
2018-06-07 Boxer Capital, LLC Purchase 193050.0
2018-06-11 venBio Select Advisor LLC Purchase 400000.0
2018-06-11 venBio Select Advisor LLC Purchase 63235.0
2018-06-26 Christensen Jamie Sale 4058.0
2018-06-26 Christensen Jamie Sale 1150.0
2018-06-27 Christensen Jamie Sale 4234.0
2018-06-27 Christensen Jamie Sale 736.0
2018-06-27 Christensen Jamie Sale 29.0
2018-08-23 BAUM CHARLES M Sale 17434.0
2018-08-23 BAUM CHARLES M Sale 32514.0
2018-08-23 BAUM CHARLES M Sale 1862.0
2019-01-07 Davis Aaron I. Sale 16643.0
2019-01-07 Davis Aaron I. Sale 8357.0
2019-01-07 Davis Aaron I. Sale 15000.0
2019-01-08 Boxer Capital, LLC Sale 150000.0
2019-01-08 Boxer Capital, LLC Sale 123800.0
2019-01-08 Boxer Capital, LLC Sale 233303.0
2019-01-08 Boxer Capital, LLC Sale 42897.0
2019-01-08 Davis Aaron I. Sale 5000.0
2019-01-08 Davis Aaron I. Sale 5000.0
2019-01-09 Boxer Capital, LLC Sale 20000.0
2019-01-09 Boxer Capital, LLC Sale 80000.0
2019-01-09 Boxer Capital, LLC Sale 50000.0
2019-01-17 Boxer Capital, LLC Purchase 150000.0
2019-01-29 Johnson Craig A Sale 8475.0
2019-01-29 Johnson Craig A Sale 8525.0
2019-02-14 LEMASTERS CHRISTOPHER C. Sale 41438.0
2019-02-14 LEMASTERS CHRISTOPHER C. Sale 18562.0
2019-02-15 Donadio Jamie A Sale 7500.0
2019-02-20 venBio Select Advisor LLC Sale 686820.0
2019-02-20 CARTER BRUCE L A Sale 900.0
2019-02-20 CARTER BRUCE L A Sale 1000.0
2019-02-20 CARTER BRUCE L A Sale 1100.0
2019-02-25 BAUM CHARLES M Sale 25722.0
2019-02-25 BAUM CHARLES M Sale 18235.0
2019-02-25 BAUM CHARLES M Sale 5687.0
2019-02-25 BAUM CHARLES M Sale 2066.0
2019-02-25 BAUM CHARLES M Sale 100.0
2019-03-01 Braslyn Ltd. Sale 275000.0
2019-03-01 Boxer Capital, LLC Sale 425000.0
2019-03-18 venBio Select Advisor LLC Sale 125000.0
2019-03-19 venBio Select Advisor LLC Sale 100000.0
2019-03-20 venBio Select Advisor LLC Sale 23781.0
2019-05-13 GREY MICHAEL G Sale 5460.0
2019-05-13 GREY MICHAEL G Sale 300.0
2019-05-16 Donadio Jamie A Sale 7500.0
2019-05-22 CARTER BRUCE L A Sale 3000.0
2019-07-17 Boxer Capital, LLC Sale 725000.0
2019-07-17 Boxer Capital, LLC Sale 8.0
2019-07-23 Avoro Capital Advisors LLC Sale 62500.0
2019-08-12 GREY MICHAEL G Sale 1032.0
2019-08-12 GREY MICHAEL G Sale 1100.0
2019-08-12 GREY MICHAEL G Sale 650.0
2019-08-12 GREY MICHAEL G Sale 260.0
2019-08-21 CARTER BRUCE L A Sale 3000.0
2019-08-22 BAUM CHARLES M Sale 11843.0
2019-08-22 BAUM CHARLES M Sale 28446.0
2019-08-22 BAUM CHARLES M Sale 3619.0
2019-08-22 BAUM CHARLES M Sale 4544.0
2019-08-22 BAUM CHARLES M Sale 1622.0
2019-08-22 BAUM CHARLES M Sale 1736.0
2019-11-12 GREY MICHAEL G Sale 3042.0
2019-11-20 CARTER BRUCE L A Sale 3000.0
2019-12-23 Christensen Jamie Sale 2499.0
2019-12-23 Christensen Jamie Sale 4167.0
2020-01-10 Boxer Capital, LLC Purchase 50000.0
2020-04-17 BAUM CHARLES M Sale 10526.0
2020-04-17 BAUM CHARLES M Sale 25184.0
2020-04-17 BAUM CHARLES M Sale 4290.0
2020-04-20 Johnson Craig A Sale 15000.0
2020-05-11 CHEN ISAN Sale 33334.0
2020-05-18 CARTER BRUCE L A Sale 4000.0
2020-06-12 Braslyn Ltd. Sale 600000.0
2020-06-12 Braslyn Ltd. Sale 600000.0
2020-08-10 FUCHS HENRY J Sale 500.0
2020-08-10 FUCHS HENRY J Sale 900.0
2020-08-10 FUCHS HENRY J Sale 1000.0
2020-08-10 FUCHS HENRY J Sale 1300.0
2020-08-10 FUCHS HENRY J Sale 5800.0
2020-08-10 FUCHS HENRY J Sale 500.0
2020-08-11 CARTER BRUCE L A Sale 1300.0
2020-08-11 CARTER BRUCE L A Sale 740.0
2020-08-11 CARTER BRUCE L A Sale 110.0
2020-08-11 CARTER BRUCE L A Sale 100.0
2020-10-28 Braslyn Ltd. Sale 44959.0
2020-10-28 Braslyn Ltd. Sale 38543.0
2020-10-28 Braslyn Ltd. Sale 45896.0
2020-10-28 Braslyn Ltd. Sale 41266.0
2020-10-28 Braslyn Ltd. Sale 38525.0
2020-10-28 Braslyn Ltd. Sale 25036.0
2020-10-28 Braslyn Ltd. Sale 37428.0
2020-10-28 Braslyn Ltd. Sale 23283.0
2020-10-28 Braslyn Ltd. Sale 500.0
2020-10-29 Braslyn Ltd. Sale 550.0
2020-10-29 Braslyn Ltd. Sale 800.0
2020-10-29 Braslyn Ltd. Sale 1088.0
2020-10-29 Braslyn Ltd. Sale 1086.0
2020-10-29 Braslyn Ltd. Sale 1674.0
2020-10-29 Braslyn Ltd. Sale 15091.0
2020-10-29 Braslyn Ltd. Sale 10599.0
2020-10-29 Braslyn Ltd. Sale 14408.0
2020-10-29 Braslyn Ltd. Sale 3108.0
2020-10-29 Braslyn Ltd. Sale 2344.0
2020-10-29 Braslyn Ltd. Sale 27992.0
2020-10-29 Braslyn Ltd. Sale 11656.0
2020-10-29 Braslyn Ltd. Sale 6775.0
2020-10-29 Braslyn Ltd. Sale 5912.0
2020-10-29 Braslyn Ltd. Sale 663.0
2020-10-29 Braslyn Ltd. Sale 818.0
2020-10-30 Boxer Capital, LLC Sale 37050.0
2020-10-30 Boxer Capital, LLC Sale 362950.0
2020-12-15 FUCHS HENRY J Sale 40
2020-12-15 FUCHS HENRY J Sale 451
2020-12-15 FUCHS HENRY J Sale 1821
2020-12-15 FUCHS HENRY J Sale 610
2020-12-15 FUCHS HENRY J Sale 4461
2020-12-15 FUCHS HENRY J Sale 1399
2020-12-15 FUCHS HENRY J Sale 1218
2020-12-14 CARTER BRUCE L A Sale 1
2020-12-14 CARTER BRUCE L A Sale 357
2020-12-14 CARTER BRUCE L A Sale 710
2020-12-14 CARTER BRUCE L A Sale 257
2020-12-14 CARTER BRUCE L A Sale 589
2020-12-14 CARTER BRUCE L A Sale 287
2020-12-14 CARTER BRUCE L A Sale 49
2020-12-14 GREY MICHAEL G Sale 89
2020-12-14 GREY MICHAEL G Sale 1019
2020-12-14 GREY MICHAEL G Sale 1997
2020-12-14 GREY MICHAEL G Sale 1807
2020-12-14 GREY MICHAEL G Sale 1284
2020-12-14 GREY MICHAEL G Sale 1653
2020-12-14 GREY MICHAEL G Sale 1815
2020-12-14 GREY MICHAEL G Sale 857
2020-12-14 GREY MICHAEL G Sale 379
2020-12-18 BAUM CHARLES M Sale 317
2020-12-18 BAUM CHARLES M Sale 100
2020-12-18 BAUM CHARLES M Sale 2020
2020-12-18 BAUM CHARLES M Sale 4250
2020-12-18 BAUM CHARLES M Sale 493
2020-12-18 BAUM CHARLES M Sale 22932
2020-12-18 BAUM CHARLES M Sale 9888
2021-01-07 REED VICKIE S Sale 241
2021-01-06 REED VICKIE S Sale 527
2021-01-06 REED VICKIE S Sale 11
2021-01-07 Hickey Benjami Sale 2069
2021-01-07 Hickey Benjami Sale 9
2021-01-06 Christensen Jami Sale 1430
2021-01-06 Christensen Jami Sale 29
2021-01-07 Faga Daniel Sale 2613
2021-01-07 Faga Daniel Sale 12
2021-01-06 BAUM CHARLES M Sale 4421
2021-01-06 BAUM CHARLES M Sale 90
2021-01-21 Johnson Craig A Sale 334
2021-01-21 Johnson Craig A Sale 44
2021-01-21 Johnson Craig A Sale 3372
2021-01-21 Johnson Craig A Sale 4562
2021-01-21 Johnson Craig A Sale 3183
2021-01-21 Johnson Craig A Sale 3505
2021-01-29 Martinez Maria E Sale 200
2021-01-29 Martinez Maria E Sale 1100
2021-01-29 Martinez Maria E Sale 975
2021-01-29 Martinez Maria E Sale 1205
2021-01-29 Martinez Maria E Sale 1579
2021-01-29 Martinez Maria E Sale 960
2021-01-29 Martinez Maria E Sale 462
2021-01-29 Martinez Maria E Sale 719
2021-01-29 Martinez Maria E Sale 250
2021-01-29 Martinez Maria E Sale 50
2021-02-02 Faga Daniel Sale 1340
2021-02-02 CARTER BRUCE L A Sale 218
2021-02-02 CARTER BRUCE L A Sale 300
2021-02-02 CARTER BRUCE L A Sale 1732
Transaction Date) Insider Transaction Type Number of Shares Transacted