| Transaction Date | Insider | Transaction Type | Number of Shares Transacted |
|---|---|---|---|
| 2014-07-23 | Kanes Stephen | Purchase | 3000.0 |
| 2014-07-23 | FRATES JAMES M | Purchase | 5000.0 |
| 2014-07-23 | JONAS JEFFREY M | Purchase | 6000.0 |
| 2014-07-23 | Anderson Thomas | Purchase | 6000.0 |
| 2014-07-23 | Robichaud Albert | Purchase | 4000.0 |
| 2014-07-23 | PAUL STEVEN M | Purchase | 10000.0 |
| 2014-07-23 | IGUCHI KIMI | Purchase | 6000.0 |
| 2015-01-26 | Kanes Stephen | Sale | 6000.0 |
| 2015-02-25 | Kanes Stephen | Sale | 6000.0 |
| 2015-03-25 | Kanes Stephen | Sale | 5400.0 |
| 2015-04-01 | PAUL STEVEN M | Sale | 20000.0 |
| 2015-05-01 | PAUL STEVEN M | Sale | 20000.0 |
| 2015-06-01 | Robichaud Albert | Sale | 4945.0 |
| 2015-06-01 | Robichaud Albert | Sale | 5624.0 |
| 2015-06-01 | Robichaud Albert | Sale | 5231.0 |
| 2015-06-01 | Robichaud Albert | Sale | 200.0 |
| 2015-06-01 | PAUL STEVEN M | Sale | 3400.0 |
| 2015-06-01 | PAUL STEVEN M | Sale | 4604.0 |
| 2015-06-01 | PAUL STEVEN M | Sale | 3291.0 |
| 2015-06-01 | PAUL STEVEN M | Sale | 8705.0 |
| 2015-06-08 | IGUCHI KIMI | Sale | 2500.0 |
| 2015-06-08 | Anderson Thomas | Sale | 4300.0 |
| 2015-06-08 | Anderson Thomas | Sale | 1200.0 |
| 2015-06-15 | JONAS JEFFREY M | Sale | 1554.0 |
| 2015-06-15 | JONAS JEFFREY M | Sale | 2420.0 |
| 2015-06-15 | JONAS JEFFREY M | Sale | 5707.0 |
| 2015-06-15 | JONAS JEFFREY M | Sale | 62364.0 |
| 2015-06-15 | JONAS JEFFREY M | Sale | 11329.0 |
| 2015-06-16 | JONAS JEFFREY M | Sale | 6804.0 |
| 2015-06-16 | JONAS JEFFREY M | Sale | 14146.0 |
| 2015-06-16 | JONAS JEFFREY M | Sale | 64973.0 |
| 2015-06-16 | JONAS JEFFREY M | Sale | 29303.0 |
| 2015-06-24 | Kanes Stephen | Sale | 6000.0 |
| 2015-07-01 | Robichaud Albert | Sale | 9338.0 |
| 2015-07-01 | Robichaud Albert | Sale | 4905.0 |
| 2015-07-01 | Robichaud Albert | Sale | 1757.0 |
| 2015-07-01 | PAUL STEVEN M | Sale | 700.0 |
| 2015-07-01 | PAUL STEVEN M | Sale | 5336.0 |
| 2015-07-01 | PAUL STEVEN M | Sale | 1600.0 |
| 2015-07-01 | PAUL STEVEN M | Sale | 1859.0 |
| 2015-07-01 | PAUL STEVEN M | Sale | 9702.0 |
| 2015-07-01 | PAUL STEVEN M | Sale | 803.0 |
| 2015-07-06 | IGUCHI KIMI | Sale | 4000.0 |
| 2015-07-23 | JONAS JEFFREY M | Sale | 3000.0 |
| 2015-07-27 | Kanes Stephen | Sale | 500.0 |
| 2015-07-27 | Kanes Stephen | Sale | 800.0 |
| 2015-07-27 | Kanes Stephen | Sale | 636.0 |
| 2015-07-27 | Kanes Stephen | Sale | 220.0 |
| 2015-07-27 | Kanes Stephen | Sale | 826.0 |
| 2015-07-27 | Kanes Stephen | Sale | 400.0 |
| 2015-07-27 | Kanes Stephen | Sale | 900.0 |
| 2015-07-27 | Kanes Stephen | Sale | 654.0 |
| 2015-08-03 | PAUL STEVEN M | Sale | 4822.0 |
| 2015-08-03 | PAUL STEVEN M | Sale | 9158.0 |
| 2015-08-03 | PAUL STEVEN M | Sale | 6020.0 |
| 2015-08-03 | Robichaud Albert | Sale | 12000.0 |
| 2015-08-10 | IGUCHI KIMI | Sale | 2762.0 |
| 2015-08-10 | IGUCHI KIMI | Sale | 900.0 |
| 2015-08-10 | IGUCHI KIMI | Sale | 338.0 |
| 2015-08-10 | Anderson Thomas | Sale | 3480.0 |
| 2015-08-10 | Anderson Thomas | Sale | 1220.0 |
| 2015-08-10 | Anderson Thomas | Sale | 1300.0 |
| 2015-08-31 | Kanes Stephen | Sale | 12000.0 |
| 2015-09-01 | PAUL STEVEN M | Sale | 10482.0 |
| 2015-09-01 | PAUL STEVEN M | Sale | 9518.0 |
| 2015-09-08 | IGUCHI KIMI | Sale | 3000.0 |
| 2015-09-28 | Kanes Stephen | Sale | 6000.0 |
| 2015-12-31 | JONAS JEFFREY M | Purchase | 226.0 |
| 2015-12-31 | IGUCHI KIMI | Purchase | 176.0 |
| 2016-01-25 | Robichaud Albert | Sale | 20000.0 |
| 2016-04-19 | Kanes Stephen | Sale | 21000.0 |
| 2016-05-16 | STARR KEVIN P | Sale | 850000.0 |
| 2016-05-16 | Third Rock Ventures II, L.P. | Sale | 850000.0 |
| 2016-07-12 | Robichaud Albert | Sale | 22000.0 |
| 2016-07-12 | IGUCHI KIMI | Sale | 5000.0 |
| 2016-09-07 | IGUCHI KIMI | Sale | 2500.0 |
| 2016-11-11 | IGUCHI KIMI | Sale | 1500.0 |
| 2016-11-15 | Anderson Thomas | Sale | 10000.0 |
| 2016-11-17 | IGUCHI KIMI | Sale | 4000.0 |
| 2017-01-13 | IGUCHI KIMI | Sale | 10000.0 |
| 2017-12-14 | Robichaud Albert | Sale | 1500.0 |
| 2017-12-14 | Robichaud Albert | Sale | 3700.0 |
| 2017-12-14 | Robichaud Albert | Sale | 16748.0 |
| 2017-12-14 | Robichaud Albert | Sale | 8734.0 |
| 2017-12-14 | Robichaud Albert | Sale | 21410.0 |
| 2017-12-14 | Robichaud Albert | Sale | 6187.0 |
| 2017-12-14 | Robichaud Albert | Sale | 700.0 |
| 2017-12-14 | Robichaud Albert | Sale | 1021.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 36989.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 71823.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 27152.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 33301.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 22334.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 13049.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 5000.0 |
| 2017-12-21 | JONAS JEFFREY M | Sale | 599.0 |
| 2017-12-22 | JONAS JEFFREY M | Sale | 12753.0 |
| 2018-01-10 | Kanes Stephen | Sale | 600.0 |
| 2018-01-10 | Kanes Stephen | Sale | 1200.0 |
| 2018-01-10 | Kanes Stephen | Sale | 1200.0 |
| 2018-01-10 | Kanes Stephen | Sale | 2200.0 |
| 2018-01-10 | Kanes Stephen | Sale | 2461.0 |
| 2018-01-10 | Kanes Stephen | Sale | 11057.0 |
| 2018-01-10 | Kanes Stephen | Sale | 9100.0 |
| 2018-01-10 | Kanes Stephen | Sale | 6923.0 |
| 2018-01-10 | Kanes Stephen | Sale | 7859.0 |
| 2018-01-10 | Kanes Stephen | Sale | 1400.0 |
| 2018-03-06 | PAUL STEVEN M | Sale | 58139.0 |
| 2018-04-17 | STARR KEVIN P | Sale | 35000.0 |
| 2018-04-18 | STARR KEVIN P | Sale | 24000.0 |
| 2018-04-23 | IGUCHI KIMI | Sale | 2999.0 |
| 2018-04-23 | IGUCHI KIMI | Sale | 4700.0 |
| 2018-04-23 | IGUCHI KIMI | Sale | 2601.0 |
| 2018-04-23 | IGUCHI KIMI | Sale | 700.0 |
| 2018-04-23 | IGUCHI KIMI | Sale | 635.0 |
| 2018-04-23 | IGUCHI KIMI | Sale | 500.0 |
| 2018-04-24 | IGUCHI KIMI | Sale | 2500.0 |
| 2018-04-24 | IGUCHI KIMI | Sale | 900.0 |
| 2018-04-24 | IGUCHI KIMI | Sale | 500.0 |
| 2018-04-24 | IGUCHI KIMI | Sale | 600.0 |
| 2018-04-24 | IGUCHI KIMI | Sale | 500.0 |
| 2018-04-25 | IGUCHI KIMI | Sale | 7818.0 |
| 2018-04-25 | IGUCHI KIMI | Sale | 2300.0 |
| 2018-04-25 | IGUCHI KIMI | Sale | 900.0 |
| 2018-04-26 | IGUCHI KIMI | Sale | 100.0 |
| 2018-04-26 | IGUCHI KIMI | Sale | 3207.0 |
| 2018-04-26 | IGUCHI KIMI | Sale | 3300.0 |
| 2018-04-26 | IGUCHI KIMI | Sale | 6075.0 |
| 2018-04-26 | IGUCHI KIMI | Sale | 100.0 |
| 2018-05-08 | FRATES JAMES M | Sale | 7000.0 |
| 2019-01-23 | FRATES JAMES M | Sale | 7500.0 |
| 2019-02-08 | Kanes Stephen | Sale | 22948.0 |
| 2019-02-12 | STARR KEVIN P | Sale | 0.0 |
| 2019-02-15 | PAUL STEVEN M | Sale | 12519.0 |
| 2019-02-15 | PAUL STEVEN M | Sale | 12510.0 |
| 2019-02-15 | PAUL STEVEN M | Sale | 12044.0 |
| 2019-02-15 | PAUL STEVEN M | Sale | 12388.0 |
| 2019-02-19 | PAUL STEVEN M | Sale | 200.0 |
| 2019-02-19 | PAUL STEVEN M | Sale | 500.0 |
| 2019-02-19 | PAUL STEVEN M | Sale | 643.0 |
| 2019-02-19 | PAUL STEVEN M | Sale | 200.0 |
| 2019-02-25 | PAUL STEVEN M | Sale | 500.0 |
| 2019-02-25 | PAUL STEVEN M | Sale | 500.0 |
| 2019-02-25 | PAUL STEVEN M | Sale | 500.0 |
| 2019-02-25 | PAUL STEVEN M | Sale | 500.0 |
| 2019-03-01 | IGUCHI KIMI | Sale | 25563.0 |
| 2019-03-01 | PAUL STEVEN M | Sale | 700.0 |
| 2019-03-01 | PAUL STEVEN M | Sale | 500.0 |
| 2019-03-01 | PAUL STEVEN M | Sale | 700.0 |
| 2019-03-01 | PAUL STEVEN M | Sale | 700.0 |
| 2019-03-18 | PAUL STEVEN M | Sale | 900.0 |
| 2019-03-18 | PAUL STEVEN M | Sale | 1200.0 |
| 2019-03-18 | PAUL STEVEN M | Sale | 800.0 |
| 2019-03-18 | PAUL STEVEN M | Sale | 875.0 |
| 2019-03-20 | PAUL STEVEN M | Sale | 14321.0 |
| 2019-03-20 | PAUL STEVEN M | Sale | 16182.0 |
| 2019-03-20 | PAUL STEVEN M | Sale | 13096.0 |
| 2019-03-20 | PAUL STEVEN M | Sale | 13047.0 |
| 2019-03-21 | PAUL STEVEN M | Sale | 2993.0 |
| 2019-03-21 | PAUL STEVEN M | Sale | 2919.0 |
| 2019-03-21 | PAUL STEVEN M | Sale | 1967.0 |
| 2019-05-06 | FRATES JAMES M | Sale | 8000.0 |
| 2019-05-10 | Cook Anne Marie | Sale | 15000.0 |
| 2019-05-22 | Cloonan Michael | Sale | 25000.0 |
| 2019-05-23 | JONAS JEFFREY M | Sale | 500.0 |
| 2019-05-23 | JONAS JEFFREY M | Sale | 1619.0 |
| 2019-05-23 | JONAS JEFFREY M | Sale | 4200.0 |
| 2019-05-23 | JONAS JEFFREY M | Sale | 31099.0 |
| 2019-05-23 | JONAS JEFFREY M | Sale | 14727.0 |
| 2019-05-23 | JONAS JEFFREY M | Sale | 1763.0 |
| 2019-05-24 | JONAS JEFFREY M | Sale | 7948.0 |
| 2019-05-24 | JONAS JEFFREY M | Sale | 24966.0 |
| 2019-05-24 | JONAS JEFFREY M | Sale | 3974.0 |
| 2019-05-24 | JONAS JEFFREY M | Sale | 2518.0 |
| 2019-05-24 | JONAS JEFFREY M | Sale | 950.0 |
| 2019-05-28 | JONAS JEFFREY M | Sale | 25510.0 |
| 2019-05-28 | JONAS JEFFREY M | Sale | 28293.0 |
| 2019-05-28 | JONAS JEFFREY M | Sale | 16651.0 |
| 2019-05-28 | JONAS JEFFREY M | Sale | 11662.0 |
| 2019-05-28 | JONAS JEFFREY M | Sale | 2545.0 |
| 2019-05-29 | JONAS JEFFREY M | Sale | 200.0 |
| 2019-05-29 | JONAS JEFFREY M | Sale | 400.0 |
| 2019-05-29 | JONAS JEFFREY M | Sale | 475.0 |
| 2019-08-15 | FRATES JAMES M | Sale | 8000.0 |
| 2019-12-09 | JONAS JEFFREY M | Purchase | 7500.0 |
| 2019-12-09 | Robichaud Albert | Purchase | 25000.0 |
| Transaction Date) | Insider | Transaction Type | Number of Shares Transacted |