Transaction Date Insider Transaction Type Number of Shares Transacted
2018-01-14 Erony Joyce Sale 88000.0
2018-01-15 Erony Joyce Sale 2000.0
2018-01-15 Erony Joyce Sale 90000.0
2018-01-15 Erony Joyce Sale 22568.0
2018-01-16 Erony Joyce Sale 30704.0
2018-01-16 Erony Joyce Sale 67432.0
2018-01-17 Erony Joyce Sale 59296.0
2018-01-17 Erony Joyce Sale 90000.0
2018-01-17 Erony Joyce Sale 54384.0
2018-01-18 Erony Joyce Sale 35616.0
2018-01-18 Erony Joyce Sale 29204.0
2018-01-22 Erony Joyce Sale 20905.0
2018-05-07 Ban Randy Purchase 900.0
2018-05-07 Buchholz Richard Purchase 4750.0
2018-05-07 Jandrich Steven Purchase 1350.0
2018-05-07 Jandrich Steven Purchase 350.0
2018-05-07 Jandrich Steven Purchase 350.0
2018-05-07 Herbert Timothy P. Purchase 350.0
2018-05-07 Erony Joyce Purchase 125000.0
2018-05-07 Mead Dana G Jr. Purchase 20000.0
2018-05-07 Tansey Casey M Purchase 187500.0
2018-05-07 Amzak Health Investors, LLC Purchase 125000.0
2018-05-07 McCormick Shawn Purchase 3000.0
2018-05-07 ORBIMED ADVISORS LLC Purchase 312500.0
2018-05-07 Khuong Chau Quang Purchase 312500.0
2018-05-07 NELSON MARILYN C Purchase 62500.0
2018-11-19 Ban Randy Sale 2156.0
2018-11-19 Ban Randy Sale 2244.0
2018-11-19 Ban Randy Sale 300.0
2018-11-19 Ban Randy Sale 300.0
2018-11-20 Herbert Timothy P. Sale 10135.0
2018-11-20 Herbert Timothy P. Sale 4065.0
2018-11-20 Herbert Timothy P. Sale 800.0
2018-11-20 Ban Randy Sale 3268.0
2018-11-20 Ban Randy Sale 1632.0
2018-11-20 Ban Randy Sale 100.0
2018-12-11 ORBIMED ADVISORS LLC Sale 614772.0
2018-12-11 Khuong Chau Quang Sale 614772.0
2018-12-11 Griffin Jerry C Sale 1300.0
2018-12-18 Herbert Timothy P. Sale 6700.0
2018-12-18 Herbert Timothy P. Sale 7400.0
2018-12-18 Herbert Timothy P. Sale 900.0
2019-01-14 Ban Randy Sale 600.0
2019-01-14 Ban Randy Sale 1960.0
2019-01-14 Ban Randy Sale 2440.0
2019-01-14 Erony Joyce Sale 88000.0
2019-01-15 Ban Randy Sale 2945.0
2019-01-15 Ban Randy Sale 2055.0
2019-01-15 Herbert Timothy P. Sale 3800.0
2019-01-15 Herbert Timothy P. Sale 11200.0
2019-01-15 Erony Joyce Sale 2000.0
2019-01-15 Erony Joyce Sale 90000.0
2019-01-15 Erony Joyce Sale 22568.0
2019-01-16 Erony Joyce Sale 30704.0
2019-01-16 Erony Joyce Sale 67432.0
2019-01-17 Erony Joyce Sale 59296.0
2019-01-17 Erony Joyce Sale 90000.0
2019-01-17 Erony Joyce Sale 54384.0
2019-01-18 Erony Joyce Sale 35616.0
2019-01-18 Erony Joyce Sale 29204.0
2019-01-22 Buchholz Richard Sale 6000.0
2019-01-22 Erony Joyce Sale 20905.0
2019-01-23 Erony Joyce Sale 12773.0
2019-01-24 Erony Joyce Sale 27118.0
2019-01-24 Erony Joyce Sale 1600.0
2019-01-25 Erony Joyce Sale 21379.0
2019-01-28 Erony Joyce Sale 34752.0
2019-01-29 Erony Joyce Sale 19120.0
2019-01-30 Erony Joyce Sale 13149.0
2019-01-31 Erony Joyce Sale 20035.0
2019-02-01 Erony Joyce Sale 15311.0
2019-02-04 Erony Joyce Sale 16708.0
2019-02-05 Erony Joyce Sale 37946.0
2019-02-19 Herbert Timothy P. Sale 15000.0
2019-02-20 Buchholz Richard Sale 2000.0
2019-03-07 Khuong Chau Quang Sale 68218.0
2019-03-07 ORBIMED ADVISORS LLC Sale 68218.0
2019-03-07 Tansey Casey M Sale 25000.0
2019-03-08 Khuong Chau Quang Sale 290231.0
2019-03-08 ORBIMED ADVISORS LLC Sale 290231.0
2019-03-19 Herbert Timothy P. Sale 12053.0
2019-03-19 Herbert Timothy P. Sale 2947.0
2019-03-20 Buchholz Richard Sale 2000.0
2019-04-01 Ban Randy Sale 200.0
2019-04-01 Ban Randy Sale 200.0
2019-04-01 Ban Randy Sale 2300.0
2019-04-01 Ban Randy Sale 2300.0
2019-04-01 NELSON MARILYN C Sale 55042.0
2019-04-01 NELSON MARILYN C Sale 27427.0
2019-04-01 NELSON MARILYN C Sale 3110.0
2019-04-01 NELSON MARILYN C Sale 2598.0
2019-04-01 NELSON MARILYN C Sale 777.0
2019-04-01 NELSON MARILYN C Sale 600.0
2019-04-02 Ban Randy Sale 3585.0
2019-04-02 Ban Randy Sale 1404.0
2019-04-02 Ban Randy Sale 11.0
2019-04-02 NELSON MARILYN C Sale 47334.0
2019-04-02 NELSON MARILYN C Sale 14666.0
2019-04-02 NELSON MARILYN C Sale 1431.0
2019-04-05 Ban Randy Sale 8600.0
2019-04-05 Ban Randy Sale 1400.0
2019-04-10 NELSON MARILYN C Sale 47015.0
2019-04-16 Buchholz Richard Sale 1974.0
2019-04-16 Buchholz Richard Sale 2026.0
2019-04-16 Herbert Timothy P. Sale 7543.0
2019-04-16 Herbert Timothy P. Sale 5301.0
2019-04-16 Herbert Timothy P. Sale 2153.0
2019-04-16 Herbert Timothy P. Sale 3.0
2019-05-01 Ban Randy Sale 5037.0
2019-05-02 Ban Randy Sale 1637.0
2019-05-03 Ban Randy Sale 3400.0
2019-05-20 Buchholz Richard Sale 4000.0
2019-05-21 Erony Joyce Sale 12854.0
2019-05-22 Erony Joyce Sale 26388.0
2019-05-23 Erony Joyce Sale 137.0
2019-05-24 Erony Joyce Sale 23004.0
2019-05-28 Herbert Timothy P. Sale 20166.0
2019-05-28 Herbert Timothy P. Sale 3634.0
2019-05-28 Herbert Timothy P. Sale 1200.0
2019-05-28 Erony Joyce Sale 600.0
2019-05-29 Erony Joyce Sale 20449.0
2019-05-30 Erony Joyce Sale 32073.0
2019-05-31 Erony Joyce Sale 34495.0
2019-06-03 Ban Randy Sale 3480.0
2019-06-03 Ban Randy Sale 3520.0
2019-06-04 Ban Randy Sale 2249.0
2019-06-04 Ban Randy Sale 686.0
2019-06-04 Ban Randy Sale 43.0
2019-06-04 Ban Randy Sale 22.0
2019-06-17 Buchholz Richard Sale 490.0
2019-06-17 Buchholz Richard Sale 3510.0
2019-06-25 Herbert Timothy P. Sale 18772.0
2019-06-25 Herbert Timothy P. Sale 6228.0
2019-07-03 NELSON MARILYN C Sale 6102.0
2019-07-03 Herbert Timothy P. Sale 10000.0
2019-07-08 NELSON MARILYN C Sale 13200.0
2019-07-08 NELSON MARILYN C Sale 5698.0
2019-07-08 Erony Joyce Sale 98355.0
2019-07-09 Erony Joyce Sale 38122.0
2019-07-10 Erony Joyce Sale 54715.0
2019-07-11 Erony Joyce Sale 31519.0
2019-07-12 Erony Joyce Sale 41075.0
2019-07-15 Jain Mudit K. Sale 3500.0
2019-07-15 Jain Mudit K. Sale 1300.0
2019-07-15 Erony Joyce Sale 52866.0
2019-07-16 Buchholz Richard Sale 4000.0
2019-07-16 Erony Joyce Sale 22738.0
2019-07-17 Erony Joyce Sale 53964.0
2019-07-18 Erony Joyce Sale 39750.0
2019-07-23 Herbert Timothy P. Sale 14900.0
2019-07-23 Herbert Timothy P. Sale 100.0
2019-08-01 Herbert Timothy P. Sale 2952.0
2019-08-01 Herbert Timothy P. Sale 6794.0
2019-08-01 Herbert Timothy P. Sale 254.0
2019-08-16 Jain Mudit K. Sale 384.0
2019-08-16 Jain Mudit K. Sale 106.0
2019-08-19 Buchholz Richard Sale 1900.0
2019-08-19 Buchholz Richard Sale 1200.0
2019-08-19 Buchholz Richard Sale 700.0
2019-08-19 Buchholz Richard Sale 200.0
2019-08-19 Jain Mudit K. Sale 1000.0
2019-08-19 Jain Mudit K. Sale 750.0
2019-08-20 Jain Mudit K. Sale 270.0
2019-08-21 Jain Mudit K. Sale 980.0
2019-08-27 Herbert Timothy P. Sale 9482.0
2019-08-27 Herbert Timothy P. Sale 3155.0
2019-08-27 Herbert Timothy P. Sale 2363.0
2019-09-03 Herbert Timothy P. Sale 5499.0
2019-09-03 Herbert Timothy P. Sale 2472.0
2019-09-03 Herbert Timothy P. Sale 1846.0
2019-09-03 Herbert Timothy P. Sale 183.0
2019-09-06 Herbert Timothy P. Sale 10000.0
2019-09-09 NELSON MARILYN C Sale 33800.0
2019-09-09 NELSON MARILYN C Sale 25000.0
2019-09-09 NELSON MARILYN C Sale 1200.0
2019-09-12 Ban Randy Sale 6918.0
2019-09-12 Ban Randy Sale 2582.0
2019-09-12 Ban Randy Sale 500.0
2019-09-20 NELSON MARILYN C Sale 30000.0
2019-09-24 Herbert Timothy P. Sale 1462.0
2019-09-24 Herbert Timothy P. Sale 1482.0
2019-09-24 Herbert Timothy P. Sale 2056.0
2019-10-07 Ban Randy Sale 700.0
2019-10-22 Herbert Timothy P. Sale 6058.0
2019-10-22 Herbert Timothy P. Sale 3838.0
2019-10-22 Herbert Timothy P. Sale 15104.0
2019-10-25 Ban Randy Sale 9300.0
2019-10-28 Ban Randy Sale 5000.0
2019-10-29 Ban Randy Sale 1998.0
2019-10-29 Ban Randy Sale 3002.0
2019-11-18 Ban Randy Sale 6390.0
2019-11-25 NELSON MARILYN C Sale 29000.0
2019-11-25 Jain Mudit K. Sale 500.0
2019-11-26 Khuong Chau Quang Sale 20135.0
2019-11-26 Khuong Chau Quang Sale 50478.0
2019-11-26 ORBIMED ADVISORS LLC Sale 20135.0
2019-11-26 ORBIMED ADVISORS LLC Sale 50478.0
2019-11-26 NELSON MARILYN C Sale 15000.0
2019-11-26 Jain Mudit K. Sale 1377.0
2019-11-26 Jain Mudit K. Sale 1800.0
2019-11-27 Khuong Chau Quang Sale 3100.0
2019-11-27 Khuong Chau Quang Sale 47981.0
2019-11-27 Khuong Chau Quang Sale 2306.0
2019-11-27 ORBIMED ADVISORS LLC Sale 3100.0
2019-11-27 ORBIMED ADVISORS LLC Sale 47981.0
2019-11-27 ORBIMED ADVISORS LLC Sale 2306.0
2019-11-27 Jain Mudit K. Sale 300.0
2019-12-04 Jain Mudit K. Sale 300.0
2019-12-06 Jain Mudit K. Sale 500.0
2019-12-06 NELSON MARILYN C Sale 15000.0
2019-12-18 Griffin Jerry C Sale 1700.0
2019-12-18 Griffin Jerry C Sale 3100.0
2019-12-18 Griffin Jerry C Sale 200.0
2019-12-18 Griffin Jerry C Sale 4500.0
2019-12-18 Griffin Jerry C Sale 500.0
2020-01-06 Griffin Jerry C Sale 106.0
2020-01-06 Griffin Jerry C Sale 1194.0
2020-01-06 Griffin Jerry C Sale 1140.0
2020-01-06 Griffin Jerry C Sale 1060.0
2020-01-06 Griffin Jerry C Sale 1500.0
2020-01-06 Jain Mudit K. Sale 500.0
2020-01-07 Griffin Jerry C Sale 3600.0
2020-01-07 Griffin Jerry C Sale 1400.0
2020-01-08 Jain Mudit K. Sale 500.0
2020-01-13 Herbert Timothy P. Sale 9757.0
2020-01-13 Herbert Timothy P. Sale 75.0
2020-01-14 Herbert Timothy P. Sale 15168.0
2020-01-21 Griffin Jerry C Sale 3300.0
2020-01-21 Griffin Jerry C Sale 1600.0
2020-01-21 Griffin Jerry C Sale 100.0
2020-01-22 Griffin Jerry C Sale 1312.0
2020-02-04 Ban Randy Sale 6797.0
2020-02-04 Ban Randy Sale 2558.0
2020-02-04 Ban Randy Sale 645.0
2020-02-28 Tansey Casey M Sale 22512.0
2020-02-28 Tansey Casey M Sale 41332.0
2020-02-28 Tansey Casey M Sale 4456.0
2020-02-28 Tansey Casey M Sale 1100.0
2020-02-28 Tansey Casey M Sale 300.0
2020-02-28 Tansey Casey M Sale 300.0
2020-03-03 ORBIMED ADVISORS LLC Sale 75000.0
2020-03-03 ORBIMED ADVISORS LLC Sale 25000.0
2020-03-03 ORBIMED ADVISORS LLC Sale 400000.0
2020-03-03 Khuong Chau Quang Sale 75000.0
2020-03-04 Khuong Chau Quang Sale 25000.0
2020-03-04 Khuong Chau Quang Sale 400000.0
2020-03-04 Ban Randy Sale 1801.0
2020-03-04 Ban Randy Sale 1673.0
2020-03-04 Ban Randy Sale 1613.0
2020-03-04 Ban Randy Sale 1730.0
2020-03-04 Ban Randy Sale 3044.0
2020-03-04 Ban Randy Sale 139.0
2020-03-06 ORBIMED ADVISORS LLC Sale 500000.0
2020-03-06 Khuong Chau Quang Sale 500000.0
2020-04-09 Ban Randy Sale 10000.0
2020-04-21 Jandrich Steven Sale 2000.0
2020-05-19 Jandrich Steven Sale 1000.0
2020-06-15 Tansey Casey M Sale 5951.0
2020-06-15 Tansey Casey M Sale 5198.0
2020-06-15 Tansey Casey M Sale 4383.0
2020-06-15 Tansey Casey M Sale 26353.0
2020-06-15 Tansey Casey M Sale 33552.0
2020-06-15 Tansey Casey M Sale 24563.0
2020-06-15 NELSON MARILYN C Sale 2799.0
2020-06-15 NELSON MARILYN C Sale 10281.0
2020-06-15 NELSON MARILYN C Sale 11915.0
2020-06-15 NELSON MARILYN C Sale 5.0
2020-06-16 NELSON MARILYN C Sale 8321.0
2020-06-16 NELSON MARILYN C Sale 1679.0
2020-06-23 Buchholz Richard Sale 4095.0
2020-06-23 Buchholz Richard Sale 5198.0
2020-06-23 Buchholz Richard Sale 2707.0
2020-06-23 Jandrich Steven Sale 1000.0
2020-07-21 Buchholz Richard Sale 2100.0
2020-07-21 Buchholz Richard Sale 900.0
2020-07-21 Jandrich Steven Sale 1000.0
2020-08-06 Herbert Timothy P. Sale 57583.0
2020-08-06 Herbert Timothy P. Sale 14770.0
2020-08-06 Herbert Timothy P. Sale 7205.0
2020-08-06 Herbert Timothy P. Sale 442.0
2020-08-07 Khuong Chau Quang Sale 28993.0
2020-08-07 ORBIMED ADVISORS LLC Sale 28993.0
2020-08-10 Khuong Chau Quang Sale 47700.0
2020-08-10 ORBIMED ADVISORS LLC Sale 47700.0
2020-08-11 Khuong Chau Quang Sale 39877.0
2020-08-11 ORBIMED ADVISORS LLC Sale 39877.0
2020-08-12 ORBIMED ADVISORS LLC Sale 42679.0
2020-08-12 Khuong Chau Quang Sale 42679.0
2020-08-13 ORBIMED ADVISORS LLC Sale 29251.0
2020-08-13 Khuong Chau Quang Sale 29251.0
2020-08-14 ORBIMED ADVISORS LLC Sale 20257.0
2020-08-14 Khuong Chau Quang Sale 20237.0
2020-08-17 Khuong Chau Quang Sale 94900.0
2020-08-17 ORBIMED ADVISORS LLC Sale 94900.0
2020-08-18 Khuong Chau Quang Sale 43543.0
2020-08-18 ORBIMED ADVISORS LLC Sale 43543.0
2020-08-18 Jandrich Steven Sale 3000.0
2020-08-27 Griffin Jerry C Sale 11252.0
2020-08-27 Griffin Jerry C Sale 15546.0
2020-08-27 Griffin Jerry C Sale 2002.0
2020-09-09 Ban Randy Sale 24808.0
2020-09-09 Ban Randy Sale 5192.0
2020-09-14 Tansey Casey M Sale 3820.0
2020-09-14 Tansey Casey M Sale 6154.0
2020-09-14 Tansey Casey M Sale 2026.0
2020-09-22 Buchholz Richard Sale 500.0
2020-09-22 Buchholz Richard Sale 600.0
2020-09-22 Buchholz Richard Sale 1900.0
2020-09-22 Buchholz Richard Sale 500.0
2020-09-22 Buchholz Richard Sale 700.0
2020-09-22 Buchholz Richard Sale 600.0
2020-09-22 Buchholz Richard Sale 1200.0
2020-10-08 NELSON MARILYN C Sale 4598.0
2020-10-08 NELSON MARILYN C Sale 7979.0
2020-10-08 NELSON MARILYN C Sale 6456.0
2020-10-08 NELSON MARILYN C Sale 2633.0
2020-10-08 NELSON MARILYN C Sale 600.0
2020-10-08 NELSON MARILYN C Sale 200.0
2020-10-08 NELSON MARILYN C Sale 2534.0
2020-10-09 NELSON MARILYN C Sale 1000.0
2020-10-20 Buchholz Richard Sale 1700.0
2020-10-20 Buchholz Richard Sale 600.0
2020-10-20 Buchholz Richard Sale 700.0
2020-11-03 NELSON MARILYN C Sale 7000.0
2020-11-05 Herbert Timothy P. Sale 474
2020-11-05 Herbert Timothy P. Sale 17412
2020-11-05 Herbert Timothy P. Sale 48663
2020-11-05 Herbert Timothy P. Sale 13451
2020-11-17 Buchholz Richard Sale 331
2020-11-17 Buchholz Richard Sale 1929
2020-11-17 Buchholz Richard Sale 340
2020-11-17 Buchholz Richard Sale 300
2020-11-17 Buchholz Richard Sale 100
2020-12-15 Buchholz Richard Sale 1853
2020-12-15 Buchholz Richard Sale 200
2020-12-15 Buchholz Richard Sale 47
2020-12-15 Buchholz Richard Sale 800
2020-12-15 Buchholz Richard Sale 100
2021-01-04 Ban Randy Sale 50
2021-01-04 Ban Randy Sale 300
2021-01-04 Ban Randy Sale 2508
2021-01-04 Ban Randy Sale 1522
2021-01-04 Ban Randy Sale 1374
2021-01-04 Ban Randy Sale 8326
2021-01-04 Ban Randy Sale 8760
2021-01-04 Ban Randy Sale 7347
Transaction Date) Insider Transaction Type Number of Shares Transacted