| Transaction Date | Insider | Transaction Type | Number of Shares Transacted |
|---|---|---|---|
| 2020-03-27 | Bonita David P | Purchase | 3681822.0 |
| 2020-03-27 | FRIEDMAN PAUL A | Purchase | 76288.0 |
| 2020-03-27 | ORBIMED ADVISORS LLC | Purchase | 3681822.0 |
| 2020-03-27 | BAKER BROS. ADVISORS LP | Purchase | 308793.0 |
| 2020-03-27 | BAKER BROS. ADVISORS LP | Purchase | 3373029.0 |
| 2020-08-21 | Bonita David P | Purchase | 1033084.0 |
| 2020-08-21 | ORBIMED ADVISORS LLC | Purchase | 1033084.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 75873.0 |
| 2020-08-21 | BAKER BROS. ADVISORS LP | Purchase | 957211.0 |
| 2020-09-25 | ORBIMED ADVISORS LLC | Purchase | 526300.0 |
| 2020-09-25 | ORBIMED ADVISORS LLC | Purchase | 710500.0 |
| 2020-09-25 | Bonita David P | Purchase | 526300.0 |
| 2020-09-25 | Bonita David P | Purchase | 710500.0 |
| 2020-09-29 | Pierce Christopher | Purchase | 3750.0 |
| 2020-09-29 | Morosini Deborah | Purchase | 444.0 |
| 2020-09-29 | Dier Mardi | Purchase | 10000.0 |
| 2020-09-29 | Combs Andrew | Purchase | 1000.0 |
| 2020-09-29 | BAKER BROS. ADVISORS LP | Purchase | 104628.0 |
| 2020-09-29 | BAKER BROS. ADVISORS LP | Purchase | 1474319.0 |
| 2021-01-11 | ORBIMED ADVISORS LLC | Purchase | 41700 |
| 2021-01-11 | Bonita David P | Purchase | 41700 |
| 2021-01-11 | BAKER BROS. ADVISORS LP | Purchase | 154222 |
| 2021-01-11 | BAKER BROS. ADVISORS LP | Purchase | 12444 |
| Transaction Date) | Insider | Transaction Type | Number of Shares Transacted |