| Transaction Date | Insider | Transaction Type | Number of Shares Transacted |
|---|---|---|---|
| 2020-07-14 | RA CAPITAL MANAGEMENT, L.P. | Purchase | 3333333.0 |
| 2020-07-14 | Flynn James E | Purchase | 500000.0 |
| 2020-07-14 | Flynn James E | Purchase | 500000.0 |
| 2020-07-14 | Novo Holdings A/S | Purchase | 555555.0 |
| 2020-07-14 | BASKETT FOREST | Purchase | 666666.0 |
| 2020-07-14 | Florence Anthony A. Jr. | Purchase | 666666.0 |
| 2020-07-14 | MAKOWER JOSHUA | Purchase | 666666.0 |
| 2020-07-14 | Makhzoumi Mohamad | Purchase | 666666.0 |
| 2020-07-14 | Sonsini Peter W. | Purchase | 666666.0 |
| 2020-07-14 | New Enterprise Associates 15, L.P. | Purchase | 666666.0 |
| 2020-07-14 | SANDELL SCOTT D | Purchase | 666666.0 |
| 2020-07-14 | GLAXOSMITHKLINE PLC | Purchase | 833333.0 |
| 2021-01-25 | Mahmood Nadi | Sale | 3500 |
| 2021-01-25 | Mahmood Nadi | Sale | 2000 |
| 2021-02-02 | Trager James | Sale | 2800 |
| 2021-02-01 | Trager James | Sale | 1566 |
| 2021-02-01 | Trager James | Sale | 2034 |
| Transaction Date) | Insider | Transaction Type | Number of Shares Transacted |