Transaction Date Insider Transaction Type Number of Shares Transacted
2003-05-16 BVF PARTNERS L P/IL Sale 240000.0
2003-05-16 BVF PARTNERS L P/IL Sale 136000.0
2003-05-16 BVF PARTNERS L P/IL Sale 368000.0
2003-11-20 RYAN THOMAS F JR Purchase 5000.0
2003-11-20 RYAN THOMAS F JR Purchase 1000.0
2003-11-20 RYAN THOMAS F JR Purchase 1000.0
2003-11-20 RYAN THOMAS F JR Purchase 1000.0
2003-11-26 RYAN THOMAS F JR Purchase 5000.0
2004-08-13 RYAN THOMAS F JR Purchase 10000.0
2005-02-18 HERLIHY WALTER C Purchase 10000.0
2005-03-10 RYAN THOMAS F JR Purchase 10000.0
2005-03-10 RYAN THOMAS F JR Purchase 2000.0
2005-03-10 RYAN THOMAS F JR Purchase 3000.0
2005-03-10 RYAN THOMAS F JR Purchase 3000.0
2005-07-29 RUSCHE JAMES R Sale 4100.0
2005-07-29 RUSCHE JAMES R Sale 4900.0
2005-07-29 RUSCHE JAMES R Sale 1000.0
2005-08-02 Whitehouse Laura Sale 2825.0
2005-08-03 RUSCHE JAMES R Sale 10000.0
2005-08-03 HERLIHY WALTER C Sale 2100.0
2005-08-03 HERLIHY WALTER C Sale 5400.0
2005-08-03 HERLIHY WALTER C Sale 4800.0
2005-08-03 HERLIHY WALTER C Sale 1300.0
2005-08-03 HERLIHY WALTER C Sale 3800.0
2005-08-03 HERLIHY WALTER C Sale 200.0
2005-08-25 DAY BARBARA BURNIM Sale 10000.0
2005-12-09 RYAN THOMAS F JR Purchase 5000.0
2005-12-09 RYAN THOMAS F JR Purchase 1000.0
2005-12-09 RYAN THOMAS F JR Purchase 1000.0
2005-12-09 RYAN THOMAS F JR Purchase 1000.0
2005-12-09 RYAN THOMAS F JR Purchase 2000.0
2005-12-09 RYAN THOMAS F JR Purchase 2000.0
2005-12-27 DAY BARBARA BURNIM Sale 8000.0
2006-01-19 DAY BARBARA BURNIM Sale 2000.0
2006-01-20 DAY BARBARA BURNIM Sale 600.0
2006-01-24 DAY BARBARA BURNIM Sale 3900.0
2006-02-14 WITT DANIEL P Sale 25400.0
2006-02-14 RUSCHE JAMES R Sale 30000.0
2006-02-17 WITT DANIEL P Sale 34600.0
2006-02-21 HERLIHY WALTER C Sale 54000.0
2006-02-28 Whitehouse Laura Sale 6500.0
2006-02-28 Whitehouse Laura Sale 700.0
2006-02-28 Whitehouse Laura Sale 400.0
2006-02-28 Whitehouse Laura Sale 600.0
2006-03-01 Whitehouse Laura Sale 1800.0
2006-09-01 DAWES KAREN A Purchase 2000.0
2006-09-06 RICH ALEXANDER Sale 5000.0
2006-12-05 RUSCHE JAMES R Sale 8000.0
2007-02-28 WITT DANIEL P Sale 6272.0
2007-02-28 WITT DANIEL P Sale 13728.0
2007-03-05 RUSCHE JAMES R Sale 10000.0
2007-03-08 HERLIHY WALTER C Sale 12736.0
2007-03-08 HERLIHY WALTER C Sale 2400.0
2007-03-08 HERLIHY WALTER C Sale 332.0
2007-03-08 HERLIHY WALTER C Sale 3000.0
2007-03-08 HERLIHY WALTER C Sale 732.0
2007-03-08 HERLIHY WALTER C Sale 1200.0
2007-03-08 HERLIHY WALTER C Sale 2600.0
2007-03-08 HERLIHY WALTER C Sale 300.0
2007-03-08 HERLIHY WALTER C Sale 1700.0
2007-06-14 RUSCHE JAMES R Sale 200.0
2007-06-14 RUSCHE JAMES R Sale 7244.0
2007-06-14 RICH ALEXANDER Sale 5000.0
2007-06-19 LANDY HAL Sale 30000.0
2007-12-13 RUSCHE JAMES R Sale 900.0
2007-12-13 RUSCHE JAMES R Sale 2357.0
2007-12-13 RUSCHE JAMES R Sale 12443.0
2007-12-13 RUSCHE JAMES R Sale 2200.0
2007-12-13 RUSCHE JAMES R Sale 2100.0
2007-12-13 RUSCHE JAMES R Sale 900.0
2007-12-13 RUSCHE JAMES R Sale 2357.0
2007-12-13 RUSCHE JAMES R Sale 12443.0
2007-12-13 RUSCHE JAMES R Sale 2200.0
2007-12-13 RUSCHE JAMES R Sale 2100.0
2007-12-13 HERLIHY WALTER C Sale 2600.0
2007-12-13 HERLIHY WALTER C Sale 16850.0
2007-12-13 HERLIHY WALTER C Sale 8850.0
2007-12-13 HERLIHY WALTER C Sale 12033.0
2007-12-13 HERLIHY WALTER C Sale 6467.0
2007-12-13 HERLIHY WALTER C Sale 600.0
2007-12-13 HERLIHY WALTER C Sale 2600.0
2008-02-14 WITT DANIEL P Sale 500.0
2008-02-14 WITT DANIEL P Sale 1700.0
2008-02-14 WITT DANIEL P Sale 1000.0
2008-02-14 WITT DANIEL P Sale 7499.0
2008-02-15 WITT DANIEL P Sale 300.0
2008-02-15 WITT DANIEL P Sale 300.0
2008-02-15 WITT DANIEL P Sale 1000.0
2008-02-19 WITT DANIEL P Sale 378.0
2008-02-19 WITT DANIEL P Sale 200.0
2008-02-19 WITT DANIEL P Sale 1457.0
2008-02-20 WITT DANIEL P Sale 200.0
2008-02-20 WITT DANIEL P Sale 2000.0
2008-03-04 WITT DANIEL P Sale 100.0
2008-03-04 WITT DANIEL P Sale 1700.0
2008-03-04 WITT DANIEL P Sale 617.0
2008-03-04 WITT DANIEL P Sale 717.0
2008-03-04 WITT DANIEL P Sale 883.0
2008-03-04 WITT DANIEL P Sale 100.0
2008-03-04 WITT DANIEL P Sale 600.0
2008-03-04 WITT DANIEL P Sale 140.0
2008-03-04 WITT DANIEL P Sale 143.0
2008-09-09 RICH ALEXANDER Sale 5000.0
2008-12-01 DAWES KAREN A Purchase 2000.0
2009-07-06 BVF PARTNERS L P/IL Sale 110800.0
2009-07-06 BVF PARTNERS L P/IL Sale 76000.0
2009-07-06 BVF PARTNERS L P/IL Sale 264000.0
2009-07-07 BVF PARTNERS L P/IL Sale 1000.0
2009-11-09 COOPER GLENN L MD Purchase 5000.0
2011-03-30 RUSCHE JAMES R Purchase 5000.0
2011-06-14 DAWES KAREN A Purchase 3600.0
2011-06-14 DAWES KAREN A Purchase 200.0
2011-06-14 DAWES KAREN A Purchase 700.0
2011-06-15 Henry Earl Webb Purchase 1100.0
2011-06-15 Henry Earl Webb Purchase 3900.0
2011-08-10 Goldberg Alfred Lewis Purchase 21000.0
2011-08-12 DAWES KAREN A Purchase 10000.0
2012-08-16 GRIFFITH MICHAEL A Purchase 1600.0
2012-08-16 GRIFFITH MICHAEL A Purchase 200.0
2012-08-16 GRIFFITH MICHAEL A Purchase 200.0
2012-08-31 Kelly William J Sale 40409.0
2012-08-31 Kelly William J Sale 8500.0
2012-08-31 Kelly William J Sale 10700.0
2012-08-31 Kelly William J Sale 9681.0
2012-08-31 Kelly William J Sale 8000.0
2012-08-31 Kelly William J Sale 9900.0
2012-08-31 Kelly William J Sale 4803.0
2012-08-31 Kelly William J Sale 800.0
2012-08-31 Kelly William J Sale 1500.0
2012-08-31 Kelly William J Sale 400.0
2012-08-31 Kelly William J Sale 100.0
2012-08-31 Kelly William J Sale 107.0
2012-08-31 Kelly William J Sale 100.0
2012-09-21 COOPER GLENN L MD Purchase 5000.0
2012-09-21 COOPER GLENN L MD Purchase 3000.0
2012-09-21 COOPER GLENN L MD Purchase 2000.0
2012-09-27 RUSCHE JAMES R Sale 2053.0
2012-09-27 RUSCHE JAMES R Sale 1138.0
2012-09-27 RUSCHE JAMES R Sale 100.0
2012-09-27 RUSCHE JAMES R Sale 476.0
2012-09-27 RUSCHE JAMES R Sale 100.0
2012-09-27 RUSCHE JAMES R Sale 1133.0
2013-05-07 Kelly William J Sale 20000.0
2013-05-13 RYAN THOMAS F JR Sale 39000.0
2013-05-13 RYAN THOMAS F JR Sale 15000.0
2013-05-14 RYAN THOMAS F JR Sale 15000.0
2013-05-14 RYAN THOMAS F JR Sale 116.0
2013-05-14 RYAN THOMAS F JR Sale 428.0
2013-05-14 RYAN THOMAS F JR Sale 1611.0
2013-05-14 HERLIHY WALTER C Sale 38486.0
2013-05-15 RYAN THOMAS F JR Sale 14884.0
2013-05-15 HERLIHY WALTER C Sale 1514.0
2013-05-15 RYAN THOMAS F JR Sale 697.0
2013-05-15 RYAN THOMAS F JR Sale 264.0
2013-05-15 RYAN THOMAS F JR Sale 1000.0
2013-05-16 RYAN THOMAS F JR Sale 4000.0
2013-05-17 RYAN THOMAS F JR Sale 10000.0
2013-05-17 RYAN THOMAS F JR Sale 6000.0
2013-05-17 RYAN THOMAS F JR Sale 1000.0
2013-06-21 DAWES KAREN A Purchase 1000.0
2013-08-08 RUSCHE JAMES R Sale 30000.0
2014-04-15 WITT DANIEL P Purchase 10000.0
2014-04-15 RUSCHE JAMES R Purchase 25000.0
2014-06-05 RYAN THOMAS F JR Sale 20000.0
2014-06-05 RYAN THOMAS F JR Sale 20000.0
2014-06-05 RYAN THOMAS F JR Sale 5000.0
2014-06-06 WITT DANIEL P Sale 47709.0
2014-06-09 RUSCHE JAMES R Sale 30000.0
2014-06-11 HERLIHY WALTER C Sale 60335.0
2014-06-24 RYAN THOMAS F JR Sale 10000.0
2014-06-27 RYAN THOMAS F JR Sale 5000.0
2014-06-27 RYAN THOMAS F JR Sale 5000.0
2014-08-13 Benjamin Howard Sale 40000.0
2014-11-10 GRIFFITH MICHAEL A Sale 7342.0
2014-11-10 GRIFFITH MICHAEL A Sale 16000.0
2014-11-11 Benjamin Howard Sale 30000.0
2014-11-13 RYAN THOMAS F JR Sale 10000.0
2014-11-18 HERLIHY WALTER C Sale 47228.0
2014-11-19 HERLIHY WALTER C Sale 4158.0
2015-03-18 Benjamin Howard Sale 15795.0
2015-03-19 RYAN THOMAS F JR Sale 10000.0
2015-03-19 HERLIHY WALTER C Sale 49695.0
2015-03-19 RUSCHE JAMES R Sale 14650.0
2015-03-20 HERLIHY WALTER C Sale 850.0
2015-03-23 HERLIHY WALTER C Sale 23686.0
2015-05-08 RYAN THOMAS F JR Sale 20000.0
2015-05-08 HERLIHY WALTER C Sale 68854.0
2015-05-11 HERLIHY WALTER C Sale 35715.0
2015-05-12 HERLIHY WALTER C Sale 45431.0
2015-05-15 RUSCHE JAMES R Sale 15000.0
2015-06-08 Benjamin Howard Sale 27303.0
2015-06-09 Benjamin Howard Sale 7697.0
2016-05-11 Benjamin Howard Sale 2889.0
2016-06-28 RYAN THOMAS F JR Sale 10000.0
2016-06-30 RYAN THOMAS F JR Sale 5000.0
2016-09-14 RYAN THOMAS F JR Sale 2700.0
2016-11-28 Hunt Anthony Sale 5000.0
2017-03-17 Snodgres Jon Sale 1909.0
2017-03-20 RYAN THOMAS F JR Sale 4000.0
2017-03-20 Benjamin Howard Sale 4968.0
2017-03-20 Benjamin Howard Sale 7248.0
2017-03-21 DAWES KAREN A Sale 2521.0
2017-12-14 Benjamin Howard Sale 12729.0
2018-01-22 Hunt Anthony Sale 8970.0
2018-03-08 RYAN THOMAS F JR Sale 4696.0
2018-05-08 EDDLEMAN ROY T Sale 49227.0
2018-05-08 EDDLEMAN ROY T Sale 25000.0
2018-05-08 EDDLEMAN ROY T Sale 49227.0
2018-05-08 EDDLEMAN ROY T Sale 25000.0
2018-05-09 BARTHELEMY NICOLAS Sale 26500.0
2018-05-09 EDDLEMAN ROY T Sale 20773.0
2018-05-09 EDDLEMAN ROY T Sale 25000.0
2018-05-09 EDDLEMAN ROY T Sale 20773.0
2018-05-09 EDDLEMAN ROY T Sale 25000.0
2018-05-11 DAWES KAREN A Sale 20000.0
2018-05-16 EDDLEMAN ROY T Sale 118850.0
2018-05-21 Hunt Anthony Sale 16249.0
2018-06-06 RYAN THOMAS F JR Sale 1932.0
2018-07-12 EDDLEMAN ROY T Sale 1.0
2018-07-12 EDDLEMAN ROY T Purchase 1.0
2018-07-26 EDDLEMAN ROY T Sale 1.0
2018-07-26 EDDLEMAN ROY T Purchase 1.0
2018-08-06 EDDLEMAN ROY T Sale 33142.0
2018-08-07 EDDLEMAN ROY T Sale 16015.0
2018-08-08 EDDLEMAN ROY T Sale 4770.0
2018-08-09 EDDLEMAN ROY T Sale 76858.0
2018-08-09 EDDLEMAN ROY T Sale 39215.0
2018-08-22 RYAN THOMAS F JR Sale 2366.0
2018-08-28 Snodgres Jon Sale 14460.0
2018-08-29 BARTHELEMY NICOLAS Sale 6580.0
2018-09-10 Hunt Anthony Sale 27566.0
2018-11-05 RYAN THOMAS F JR Sale 1763.0
2018-11-26 Snodgres Jon Sale 31753.0
2018-12-18 KURIYEL RALF Sale 311.0
2019-02-28 KURIYEL RALF Sale 185.0
2019-02-28 Hunt Anthony Sale 7475.0
2019-02-28 Snodgres Jon Sale 1875.0
2019-03-05 Snodgres Jon Sale 2645.0
2019-03-05 KURIYEL RALF Sale 2240.0
2019-03-05 Hunt Anthony Sale 13000.0
2019-03-18 Hunt Anthony Sale 10041.0
2019-03-18 Hunt Anthony Sale 4009.0
2019-03-18 Hunt Anthony Sale 500.0
2019-03-25 Snodgres Jon Sale 5458.0
2019-03-25 Snodgres Jon Sale 1009.0
2019-05-23 COOPER GLENN L MD Sale 4734.0
2019-05-23 COOPER GLENN L MD Sale 266.0
2019-05-23 COOPER GLENN L MD Sale 4734.0
2019-05-23 COOPER GLENN L MD Sale 266.0
2019-06-17 DAWES KAREN A Sale 1295.0
2019-09-09 Hunt Anthony Sale 4131.0
2019-09-09 Hunt Anthony Sale 4926.0
2019-09-09 Hunt Anthony Sale 1751.0
2019-09-09 Hunt Anthony Sale 740.0
2019-09-09 Hunt Anthony Sale 222.0
2019-09-09 Hunt Anthony Sale 288.0
2019-09-09 Hunt Anthony Sale 36.0
2019-09-19 Hunt Anthony Sale 638.0
2019-09-19 Hunt Anthony Sale 2510.0
2019-09-19 Hunt Anthony Sale 452.0
2020-02-21 DAWES KAREN A Sale 300.0
2020-02-21 DAWES KAREN A Sale 945.0
2020-02-21 DAWES KAREN A Sale 906.0
2020-02-21 DAWES KAREN A Sale 1849.0
2020-02-24 Cox John Sale 100.0
2020-02-24 Cox John Sale 4355.0
2020-02-25 Hunt Anthony Sale 1699.0
2020-02-25 Hunt Anthony Sale 8412.0
2020-02-25 Hunt Anthony Sale 1624.0
2020-02-26 KURIYEL RALF Sale 195.0
2020-02-26 Snodgres Jon Sale 154.0
2020-02-26 Snodgres Jon Sale 946.0
2020-02-26 Hunt Anthony Sale 1881.0
2020-02-26 Hunt Anthony Sale 1594.0
2020-03-03 Hunt Anthony Sale 2090.0
2020-03-03 Hunt Anthony Sale 100.0
2020-03-03 KURIYEL RALF Sale 450.0
2020-03-03 RYAN THOMAS F JR Sale 2225.0
2020-03-03 Snodgres Jon Sale 610.0
2020-03-04 Hunt Anthony Sale 12300.0
2020-03-04 Cox John Sale 10000.0
2020-03-04 KURIYEL RALF Sale 650.0
2020-03-04 KURIYEL RALF Sale 1905.0
2020-03-04 RYAN THOMAS F JR Sale 4796.0
2020-03-04 Snodgres Jon Sale 1045.0
2020-03-16 RYAN THOMAS F JR Sale 1000.0
2020-03-18 Cox John Sale 24533.0
2020-03-18 Cox John Sale 1187.0
2020-03-18 Cox John Sale 1016.0
2020-03-24 Cox John Sale 1858.0
2020-04-03 BARTHELEMY NICOLAS Sale 2688.0
2020-04-20 DAWES KAREN A Sale 3202.0
2020-04-20 DAWES KAREN A Sale 8998.0
2020-04-20 DAWES KAREN A Sale 3202.0
2020-04-20 DAWES KAREN A Sale 8998.0
2020-04-22 BARTHELEMY NICOLAS Sale 2688.0
2020-05-13 KURIYEL RALF Sale 1612.0
2020-05-13 KURIYEL RALF Sale 6293.0
2020-05-13 KURIYEL RALF Sale 95.0
2020-05-13 Snodgres Jon Sale 5358.0
2020-05-13 Snodgres Jon Sale 2865.0
2020-05-13 Snodgres Jon Sale 1612.0
2020-05-13 Snodgres Jon Sale 1700.0
2020-05-13 Snodgres Jon Sale 3013.0
2020-05-13 Snodgres Jon Sale 846.0
2020-05-15 Snodgres Jon Sale 660.0
2020-05-15 KURIYEL RALF Sale 435.0
2020-05-18 DAWES KAREN A Sale 712.0
2020-05-18 DAWES KAREN A Sale 160.0
2020-05-18 DAWES KAREN A Sale 269.0
2020-05-18 DAWES KAREN A Sale 122.0
2020-05-18 DAWES KAREN A Sale 180.0
2020-05-18 DAWES KAREN A Sale 77.0
2020-05-18 DAWES KAREN A Sale 80.0
2020-05-18 DAWES KAREN A Sale 712.0
2020-05-18 DAWES KAREN A Sale 160.0
2020-05-18 DAWES KAREN A Sale 269.0
2020-05-18 DAWES KAREN A Sale 122.0
2020-05-18 DAWES KAREN A Sale 180.0
2020-05-18 DAWES KAREN A Sale 77.0
2020-05-18 DAWES KAREN A Sale 80.0
2020-05-18 BARTHELEMY NICOLAS Sale 3009.0
2020-05-20 DAWES KAREN A Sale 10.0
2020-05-20 DAWES KAREN A Sale 43.0
2020-05-20 DAWES KAREN A Sale 282.0
2020-05-20 DAWES KAREN A Sale 182.0
2020-05-21 Hunt Anthony Sale 16496.0
2020-05-21 Hunt Anthony Sale 28980.0
2020-05-21 Hunt Anthony Sale 1377.0
2020-05-21 Hunt Anthony Sale 100.0
2020-06-18 DAWES KAREN A Sale 2677.0
2020-06-18 DAWES KAREN A Sale 5243.0
2020-06-18 DAWES KAREN A Sale 8217.0
2020-06-18 DAWES KAREN A Sale 2568.0
2020-07-31 RYAN THOMAS F JR Sale 2109.0
2020-07-31 RYAN THOMAS F JR Sale 986.0
2020-08-06 KURIYEL RALF Sale 5000.0
2020-09-10 Hunt Anthony Sale 4856.0
2020-09-10 Hunt Anthony Sale 11132.0
2020-09-10 Hunt Anthony Sale 26966.0
2020-09-10 Hunt Anthony Sale 2397.0
2020-11-09 BARTHELEMY NICOLAS Sale 1214
2020-11-10 Snodgres J Sale 3086
2020-11-09 Snodgres J Sale 705
2020-11-11 RYAN THOMAS F JR Sale 934
2020-11-19 Hunt Anthony Sale 1430
2020-11-19 Hunt Anthony Sale 6300
2020-11-19 Hunt Anthony Sale 6823
2020-11-19 Hunt Anthony Sale 5447
2020-12-16 KURIYEL RALF Sale 435
2021-01-04 Snodgres J Sale 59
2021-01-04 Snodgres J Sale 571
2021-01-04 Snodgres J Sale 218
2021-01-04 Snodgres J Sale 918
2021-01-04 Snodgres J Sale 202
2021-01-04 Snodgres J Sale 1333
2021-01-04 Snodgres J Sale 656
Transaction Date) Insider Transaction Type Number of Shares Transacted