Transaction Date Insider Transaction Type Number of Shares Transacted
2003-09-19 BAKER BIOTECH CAPITAL II GP LLC Purchase 556350.0000
2003-09-19 BAKER BIOTECH CAPITAL GP LLC Purchase 526000.0000
2003-09-19 BAKER BROS CAPITAL GP LLC Purchase 107650.0000
2003-09-22 BAKER BIOTECH CAPITAL GP LLC Purchase 66300.0000
2003-09-22 BAKER BIOTECH CAPITAL GP LLC Purchase 1000.0000
2003-09-22 BAKER BIOTECH CAPITAL II GP LLC Purchase 70100.0000
2003-09-22 BAKER BIOTECH CAPITAL II GP LLC Purchase 1000.0000
2003-09-22 BAKER BROS CAPITAL GP LLC Purchase 13600.0000
2003-09-22 BAKER BROS CAPITAL GP LLC Purchase 200.0000
2004-01-14 TISCH JAMES S Sale -
2004-01-14 TISCH DANIEL R Sale -
2004-01-14 TISCH BONNIE J Sale -
2004-01-14 TISCH ANDREW H Sale -
2004-01-14 TISCH THOMAS J Sale -
2004-01-14 DAMIAL FOUNDATION INC Sale -
2004-02-03 TISCH DANIEL R Sale -
2004-02-03 TISCH JAMES S Sale -
2004-02-03 TISCH ANDREW H Sale -
2004-02-03 DAMIAL FOUNDATION INC Sale -
2004-02-03 TISCH THOMAS J Sale -
2004-02-09 TISCH ANDREW H Sale -
2004-02-09 TISCH DANIEL R Sale -
2004-02-09 TISCH THOMAS J Sale -
2004-02-09 TISCH JAMES S Sale -
2004-02-10 DAMIAL FOUNDATION INC Sale -
2004-02-10 TISCH ANDREW H Sale -
2004-02-10 TISCH JAMES S Sale -
2004-02-10 TISCH THOMAS J Sale -
2004-02-10 TISCH DANIEL R Sale -
2004-02-11 TISCH JAMES S Sale -
2004-02-11 TISCH JAMES S Sale -
2004-02-11 TISCH JAMES S Sale -
2004-02-11 TISCH JAMES S Sale -
2004-02-11 TISCH THOMAS J Sale -
2004-02-11 TISCH THOMAS J Sale -
2004-02-11 TISCH THOMAS J Sale -
2004-02-11 TISCH THOMAS J Sale -
2004-02-11 TISCH DANIEL R Sale -
2004-02-11 TISCH DANIEL R Sale -
2004-02-11 TISCH DANIEL R Sale -
2004-02-11 TISCH DANIEL R Sale -
2004-02-11 DAMIAL FOUNDATION INC Sale -
2004-02-11 TISCH ANDREW H Sale -
2004-02-11 TISCH ANDREW H Sale -
2004-02-11 TISCH ANDREW H Sale -
2004-02-11 TISCH ANDREW H Sale -
2004-02-12 TISCH DANIEL R Sale -
2004-02-12 TISCH THOMAS J Sale -
2004-02-12 TISCH JAMES S Sale -
2004-02-12 TISCH ANDREW H Sale -
2004-02-19 BAKER BIOTECH CAPITAL GP LLC Purchase -
2004-02-19 BAKER BIOTECH CAPITAL II GP LLC Purchase -
2004-02-19 BAKER BIOTECH CAPITAL GP LLC Purchase -
2004-02-19 BAKER BIOTECH CAPITAL II GP LLC Purchase -
2004-08-12 TISCH THOMAS J Purchase 255750.0000
2004-08-12 TISCH JAMES S Purchase 255750.0000
2004-08-12 TISCH ANDREW H Purchase 255750.0000
2004-08-12 TISCH DANIEL R Purchase 255750.0000
2004-08-12 TISCH DANIEL R Purchase 255750.0000
2004-08-12 TISCH ANDREW H Purchase 255750.0000
2004-08-12 TISCH JAMES S Purchase 255750.0000
2004-08-12 TISCH THOMAS J Purchase 255750.0000
2004-08-16 FRIEDMAN PAUL A Purchase 1573.0000
2004-08-16 FRIEDMAN PAUL A Purchase 1927.0000
2004-09-09 BROOKE PAUL A Purchase 100000.0000
2004-11-01 BAKER JULIAN Purchase 18606.0000
2004-11-01 BAKER JULIAN Purchase 94674.0000
2004-11-01 BAKER JULIAN Purchase 86383.0000
2004-11-01 BAKER JULIAN Purchase 11912.0000
2004-11-01 BAKER JULIAN Purchase 74190.0000
2004-11-01 BAKER JULIAN Purchase 14235.0000
2004-11-12 BAKER JULIAN Purchase -
2004-11-12 BAKER JULIAN Purchase -
2004-11-12 BAKER JULIAN Purchase -
2004-11-12 BAKER JULIAN Purchase -
2004-11-12 BAKER JULIAN Purchase -
2004-11-12 BAKER JULIAN Purchase -
2004-11-12 BAKER JULIAN Purchase -
2004-11-12 BAKER JULIAN Purchase -
2005-03-09 DE SCHUTTER RICHARD U Purchase 20000.0000
2005-08-23 FRIEDMAN PAUL A Purchase 200.0000
2005-08-23 FRIEDMAN PAUL A Purchase 1200.0000
2005-08-23 FRIEDMAN PAUL A Purchase 1300.0000
2006-04-04 SCHRECK PATRICIA A Purchase 2000.0000
2006-04-04 HASTINGS DAVID C Purchase 2500.0000
2006-04-04 FRIEDMAN PAUL A Purchase 5500.0000
2006-04-06 SWAIN PAULA J Purchase 3000.0000
2006-04-17 METCALF BRIAN W Purchase 1632.0000
2006-04-17 METCALF BRIAN W Purchase 3368.0000
2007-08-01 14159 capital (GP), LLC Purchase 7536.0000
2007-08-01 Baker Bros. Capital (GP), LLC Purchase 604.0000
2007-08-01 Baker Brothers Life Sciences Capital (GP), LLC Purchase 237052.0000
2007-08-01 Baker Biotech Capital (GP), LLC Purchase 89883.0000
2007-08-02 14159 capital (GP), LLC Purchase 1463.0000
2007-08-02 Baker Bros. Capital (GP), LLC Purchase 117.0000
2007-08-02 Baker Brothers Life Sciences Capital (GP), LLC Purchase 46012.0000
2007-08-02 Baker Biotech Capital (GP), LLC Purchase 17446.0000
2007-08-03 14159 capital (GP), LLC Purchase 5366.0000
2007-08-03 Baker Bros. Capital (GP), LLC Purchase 430.0000
2007-08-03 Baker Brothers Life Sciences Capital (GP), LLC Purchase 168797.0000
2007-08-03 Baker Biotech Capital (GP), LLC Purchase 64003.0000
2007-08-17 FRIEDMAN PAUL A Purchase 3000.0000
2007-08-17 FRIEDMAN PAUL A Purchase 2000.0000
2007-08-17 FRIEDMAN PAUL A Purchase 5000.0000
2007-08-17 FRIEDMAN PAUL A Purchase 400.0000
2007-08-17 FRIEDMAN PAUL A Purchase 4600.0000
2007-08-17 FRIEDMAN PAUL A Purchase 1665.0000
2007-11-09 Baker Bros. Capital (GP), LLC Purchase 10.0000
2007-11-09 Baker Bros. Capital (GP), LLC Purchase 532.0000
2007-11-09 Baker Brothers Life Sciences Capital (GP), LLC Purchase 3629.0000
2007-11-09 Baker Brothers Life Sciences Capital (GP), LLC Purchase 198883.0000
2007-11-09 Baker Biotech Capital (GP), LLC Purchase 1434.0000
2007-11-09 Baker Biotech Capital (GP), LLC Purchase 78599.0000
2007-11-09 14159 capital (GP), LLC Purchase 114.0000
2007-11-09 14159 capital (GP), LLC Purchase 6286.0000
2007-11-09 Baker / Tisch Capital (GP), LLC Purchase 13.0000
2007-11-09 Baker / Tisch Capital (GP), LLC Purchase 700.0000
2007-11-12 Baker Bros. Capital (GP), LLC Purchase 377.0000
2007-11-12 Baker Bros. Capital (GP), LLC Purchase 462.0000
2007-11-12 Baker Bros. Capital (GP), LLC Purchase 57.0000
2007-11-12 Baker Bros. Capital (GP), LLC Purchase 30.0000
2007-11-12 Baker Brothers Life Sciences Capital (GP), LLC Purchase 140951.0000
2007-11-12 Baker Brothers Life Sciences Capital (GP), LLC Purchase 172694.0000
2007-11-12 Baker Brothers Life Sciences Capital (GP), LLC Purchase 21397.0000
2007-11-12 Baker Brothers Life Sciences Capital (GP), LLC Purchase 11165.0000
2007-11-12 Baker Biotech Capital (GP), LLC Purchase 55704.0000
2007-11-12 Baker Biotech Capital (GP), LLC Purchase 68249.0000
2007-11-12 Baker Biotech Capital (GP), LLC Purchase 8456.0000
2007-11-12 Baker Biotech Capital (GP), LLC Purchase 4413.0000
2007-11-12 14159 capital (GP), LLC Purchase 4455.0000
2007-11-12 14159 capital (GP), LLC Purchase 5458.0000
2007-11-12 14159 capital (GP), LLC Purchase 677.0000
2007-11-12 14159 capital (GP), LLC Purchase 353.0000
2007-11-12 Baker / Tisch Capital (GP), LLC Purchase 496.0000
2007-11-12 Baker / Tisch Capital (GP), LLC Purchase 608.0000
2007-11-12 Baker / Tisch Capital (GP), LLC Purchase 75.0000
2007-11-12 Baker / Tisch Capital (GP), LLC Purchase 39.0000
2007-11-13 Baker Bros. Capital (GP), LLC Purchase 63.0000
2007-11-13 Baker Bros. Capital (GP), LLC Purchase 39.0000
2007-11-13 Baker Bros. Capital (GP), LLC Purchase 53.0000
2007-11-13 Baker Bros. Capital (GP), LLC Purchase 234.0000
2007-11-13 Baker Brothers Life Sciences Capital (GP), LLC Purchase 23377.0000
2007-11-13 Baker Brothers Life Sciences Capital (GP), LLC Purchase 14490.0000
2007-11-13 Baker Brothers Life Sciences Capital (GP), LLC Purchase 19844.0000
2007-11-13 Baker Brothers Life Sciences Capital (GP), LLC Purchase 87343.0000
2007-11-13 Baker Biotech Capital (GP), LLC Purchase 9239.0000
2007-11-13 Baker Biotech Capital (GP), LLC Purchase 5727.0000
2007-11-13 Baker Biotech Capital (GP), LLC Purchase 7843.0000
2007-11-13 Baker Biotech Capital (GP), LLC Purchase 34518.0000
2007-11-13 14159 capital (GP), LLC Purchase 739.0000
2007-11-13 14159 capital (GP), LLC Purchase 457.0000
2007-11-13 14159 capital (GP), LLC Purchase 627.0000
2007-11-13 14159 capital (GP), LLC Purchase 2760.0000
2007-11-13 Baker / Tisch Capital (GP), LLC Purchase 82.0000
2007-11-13 Baker / Tisch Capital (GP), LLC Purchase 51.0000
2007-11-13 Baker / Tisch Capital (GP), LLC Purchase 70.0000
2007-11-13 Baker / Tisch Capital (GP), LLC Purchase 308.0000
2007-11-14 Baker / Tisch Capital (GP), LLC Purchase 6.0000
2007-11-14 Baker / Tisch Capital (GP), LLC Purchase 440.0000
2007-11-14 Baker Bros. Capital (GP), LLC Purchase 5.0000
2007-11-14 Baker Bros. Capital (GP), LLC Purchase 335.0000
2007-11-14 Baker Biotech Capital (GP), LLC Purchase 709.0000
2007-11-14 Baker Biotech Capital (GP), LLC Purchase 49390.0000
2007-11-14 Baker Brothers Life Sciences Capital (GP), LLC Purchase 1793.0000
2007-11-14 Baker Brothers Life Sciences Capital (GP), LLC Purchase 124973.0000
2007-11-14 14159 capital (GP), LLC Purchase 57.0000
2007-11-14 14159 capital (GP), LLC Purchase 3949.0000
2007-11-15 Baker / Tisch Capital (GP), LLC Purchase 381.0000
2007-11-15 Baker / Tisch Capital (GP), LLC Purchase 1.0000
2007-11-15 Baker Bros. Capital (GP), LLC Purchase 290.0000
2007-11-15 Baker Biotech Capital (GP), LLC Purchase 42783.0000
2007-11-15 Baker Biotech Capital (GP), LLC Purchase 60.0000
2007-11-15 Baker Brothers Life Sciences Capital (GP), LLC Purchase 108254.0000
2007-11-15 Baker Brothers Life Sciences Capital (GP), LLC Purchase 151.0000
2007-11-15 14159 capital (GP), LLC Purchase 3421.0000
2007-11-15 14159 capital (GP), LLC Purchase 5.0000
2007-11-16 Baker / Tisch Capital (GP), LLC Purchase 225.0000
2007-11-16 Baker Bros. Capital (GP), LLC Purchase 274.0000
2007-11-16 Baker Biotech Capital (GP), LLC Purchase 33157.0000
2007-11-16 Baker Brothers Life Sciences Capital (GP), LLC Purchase 102285.0000
2007-11-16 14159 capital (GP), LLC Purchase 3232.0000
2007-11-19 Baker / Tisch Capital (GP), LLC Purchase 318.0000
2007-11-19 Baker Bros. Capital (GP), LLC Purchase 387.0000
2007-11-19 14159 capital (GP), LLC Purchase 4566.0000
2007-11-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 144486.0000
2007-11-19 Baker Biotech Capital (GP), LLC Purchase 46836.0000
2007-11-20 Baker Bros. Capital (GP), LLC Purchase 210.0000
2007-11-20 14159 capital (GP), LLC Purchase 2478.0000
2007-11-20 Baker Brothers Life Sciences Capital (GP), LLC Purchase 78415.0000
2007-11-20 Baker Biotech Capital (GP), LLC Purchase 13945.0000
2007-11-21 Baker Bros. Capital (GP), LLC Purchase 150.0000
2007-11-21 14159 capital (GP), LLC Purchase 1770.0000
2007-11-21 Baker Brothers Life Sciences Capital (GP), LLC Purchase 56010.0000
2007-11-21 Baker Biotech Capital (GP), LLC Purchase 9961.0000
2007-11-26 14159 capital (GP), LLC Purchase 2715.0000
2007-11-26 Baker Brothers Life Sciences Capital (GP), LLC Purchase 85927.0000
2007-11-26 Baker Biotech Capital (GP), LLC Purchase 15282.0000
2007-11-26 Baker Bros. Capital (GP), LLC Purchase 230.0000
2007-11-27 14159 capital (GP), LLC Purchase 6262.0000
2007-11-27 Baker Brothers Life Sciences Capital (GP), LLC Purchase 198138.0000
2007-11-27 Baker Biotech Capital (GP), LLC Purchase 35237.0000
2007-11-27 Baker Bros. Capital (GP), LLC Purchase 530.0000
2007-11-28 14159 capital (GP), LLC Purchase 4042.0000
2007-11-28 Baker Brothers Life Sciences Capital (GP), LLC Purchase 127875.0000
2007-11-28 Baker Biotech Capital (GP), LLC Purchase 22741.0000
2007-11-28 Baker Bros. Capital (GP), LLC Purchase 342.0000
2007-11-29 Baker Bros. Capital (GP), LLC Purchase 47.0000
2007-11-29 Baker Brothers Life Sciences Capital (GP), LLC Purchase 17572.0000
2007-11-29 14159 capital (GP), LLC Purchase 556.0000
2007-11-29 Baker Biotech Capital (GP), LLC Purchase 3125.0000
2007-11-30 Baker Bros. Capital (GP), LLC Purchase 147.0000
2007-11-30 Baker Brothers Life Sciences Capital (GP), LLC Purchase 54899.0000
2007-11-30 14159 capital (GP), LLC Purchase 1734.0000
2007-11-30 Baker Biotech Capital (GP), LLC Purchase 9764.0000
2007-12-03 Baker Bros. Capital (GP), LLC Purchase 64.0000
2007-12-03 Baker Brothers Life Sciences Capital (GP), LLC Purchase 23842.0000
2007-12-03 14159 capital (GP), LLC Purchase 753.0000
2007-12-03 Baker Biotech Capital (GP), LLC Purchase 4241.0000
2007-12-04 Baker Bros. Capital (GP), LLC Purchase 153.0000
2007-12-04 Baker Brothers Life Sciences Capital (GP), LLC Purchase 57303.0000
2007-12-04 14159 capital (GP), LLC Purchase 1812.0000
2007-12-04 Baker Biotech Capital (GP), LLC Purchase 19593.0000
2007-12-04 Baker / Tisch Capital (GP), LLC Purchase 1139.0000
2007-12-10 Baker / Tisch Capital (GP), LLC Purchase 2265.0000
2007-12-10 Baker Biotech Capital (GP), LLC Purchase 42843.0000
2007-12-10 Baker Biotech Capital (GP), LLC Purchase 42843.0000
2007-12-10 Baker / Tisch Capital (GP), LLC Purchase 2265.0000
2007-12-10 Baker Bros. Capital (GP), LLC Purchase 296.0000
2007-12-10 14159 capital (GP), LLC Purchase 3445.0000
2007-12-10 Baker Brothers Life Sciences Capital (GP), LLC Purchase 108461.0000
2007-12-11 Baker / Tisch Capital (GP), LLC Purchase 1832.0000
2007-12-11 Baker / Tisch Capital (GP), LLC Purchase 1392.0000
2007-12-11 Baker Biotech Capital (GP), LLC Purchase 34670.0000
2007-12-11 Baker Biotech Capital (GP), LLC Purchase 26336.0000
2007-12-11 Baker Biotech Capital (GP), LLC Purchase 34670.0000
2007-12-11 Baker Biotech Capital (GP), LLC Purchase 26336.0000
2007-12-11 Baker / Tisch Capital (GP), LLC Purchase 1832.0000
2007-12-11 Baker / Tisch Capital (GP), LLC Purchase 1392.0000
2007-12-11 Baker Bros. Capital (GP), LLC Purchase 240.0000
2007-12-11 Baker Bros. Capital (GP), LLC Purchase 182.0000
2007-12-11 14159 capital (GP), LLC Purchase 2788.0000
2007-12-11 14159 capital (GP), LLC Purchase 2118.0000
2007-12-11 Baker Brothers Life Sciences Capital (GP), LLC Purchase 87770.0000
2007-12-11 Baker Brothers Life Sciences Capital (GP), LLC Purchase 66672.0000
2007-12-12 Baker / Tisch Capital (GP), LLC Purchase 3560.0000
2007-12-12 Baker Biotech Capital (GP), LLC Purchase 67353.0000
2007-12-12 Baker Biotech Capital (GP), LLC Purchase 67353.0000
2007-12-12 Baker / Tisch Capital (GP), LLC Purchase 3560.0000
2007-12-12 Baker Bros. Capital (GP), LLC Purchase 465.0000
2007-12-12 14159 capital (GP), LLC Purchase 5418.0000
2007-12-12 Baker Brothers Life Sciences Capital (GP), LLC Purchase 170512.0000
2007-12-17 14159 capital (GP), LLC Purchase 3005.0000
2007-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 94565.0000
2007-12-17 Baker Biotech Capital (GP), LLC Purchase 37354.0000
2007-12-17 Baker Bros. Capital (GP), LLC Purchase 258.0000
2007-12-17 Baker / Tisch Capital (GP), LLC Purchase 1974.0000
2007-12-18 14159 capital (GP), LLC Purchase 1710.0000
2007-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 53824.0000
2007-12-18 Baker Biotech Capital (GP), LLC Purchase 21261.0000
2007-12-18 Baker Bros. Capital (GP), LLC Purchase 147.0000
2007-12-18 Baker / Tisch Capital (GP), LLC Purchase 1124.0000
2007-12-19 14159 capital (GP), LLC Purchase 2834.0000
2007-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 89198.0000
2007-12-19 Baker Biotech Capital (GP), LLC Purchase 35234.0000
2007-12-19 Baker Bros. Capital (GP), LLC Purchase 243.0000
2007-12-19 Baker / Tisch Capital (GP), LLC Purchase 1862.0000
2008-01-04 Baker Bros. Capital (GP), LLC Purchase 815.0000
2008-01-04 Baker / Tisch Capital (GP), LLC Purchase 6237.0000
2008-01-04 Baker Biotech Capital (GP), LLC Purchase 118009.0000
2008-01-04 14159 capital (GP), LLC Purchase 9492.0000
2008-01-04 Baker Brothers Life Sciences Capital (GP), LLC Purchase 298752.0000
2008-01-07 Baker Bros. Capital (GP), LLC Purchase 579.0000
2008-01-07 Baker / Tisch Capital (GP), LLC Purchase 4432.0000
2008-01-07 Baker Biotech Capital (GP), LLC Purchase 83853.0000
2008-01-07 14159 capital (GP), LLC Purchase 6744.0000
2008-01-07 Baker Brothers Life Sciences Capital (GP), LLC Purchase 212282.0000
2008-01-08 Baker Bros. Capital (GP), LLC Purchase 1252.0000
2008-01-08 Baker Bros. Capital (GP), LLC Purchase 66.0000
2008-01-08 Baker / Tisch Capital (GP), LLC Purchase 9576.0000
2008-01-08 Baker / Tisch Capital (GP), LLC Purchase 504.0000
2008-01-08 Baker Biotech Capital (GP), LLC Purchase 181168.0000
2008-01-08 Baker Biotech Capital (GP), LLC Purchase 9541.0000
2008-01-08 14159 capital (GP), LLC Purchase 14569.0000
2008-01-08 14159 capital (GP), LLC Purchase 768.0000
2008-01-08 Baker Brothers Life Sciences Capital (GP), LLC Purchase 458644.0000
2008-01-08 Baker Brothers Life Sciences Capital (GP), LLC Purchase 24154.0000
2008-01-09 Baker / Tisch Capital (GP), LLC Purchase 1892.0000
2008-01-09 14159 capital (GP), LLC Purchase 2878.0000
2008-01-09 Baker Brothers Life Sciences Capital (GP), LLC Purchase 90591.0000
2008-01-09 Baker Biotech Capital (GP), LLC Purchase 35783.0000
2008-01-09 Baker Bros. Capital (GP), LLC Purchase 247.0000
2008-01-10 Baker / Tisch Capital (GP), LLC Purchase 26.0000
2008-01-10 14159 capital (GP), LLC Purchase 40.0000
2008-01-10 Baker Brothers Life Sciences Capital (GP), LLC Purchase 1241.0000
2008-01-10 Baker Biotech Capital (GP), LLC Purchase 490.0000
2008-01-10 Baker Bros. Capital (GP), LLC Purchase 3.0000
2008-01-11 Baker / Tisch Capital (GP), LLC Purchase 641.0000
2008-01-11 14159 capital (GP), LLC Purchase 973.0000
2008-01-11 Baker Brothers Life Sciences Capital (GP), LLC Purchase 30682.0000
2008-01-11 Baker Biotech Capital (GP), LLC Purchase 12120.0000
2008-01-11 Baker Bros. Capital (GP), LLC Purchase 84.0000
2008-01-14 Baker / Tisch Capital (GP), LLC Purchase 723.0000
2008-01-14 Baker Biotech Capital (GP), LLC Purchase 13675.0000
2008-01-14 14159 capital (GP), LLC Purchase 1101.0000
2008-01-14 Baker Brothers Life Sciences Capital (GP), LLC Purchase 34621.0000
2008-01-14 Baker Bros. Capital (GP), LLC Purchase 94.0000
2008-01-22 Baker Bros. Capital (GP), LLC Purchase 1.0000
2008-01-22 Baker / Tisch Capital (GP), LLC Purchase 4.0000
2008-01-22 Baker Biotech Capital (GP), LLC Purchase 65.0000
2008-01-22 Baker Brothers Life Sciences Capital (GP), LLC Purchase 223.0000
2008-01-22 14159 capital (GP), LLC Purchase 7.0000
2008-01-29 Baker Brothers Life Sciences Capital (GP), LLC Purchase 117000.0000
2008-01-29 Baker / Tisch Capital (GP), LLC Purchase 3000.0000
2008-01-29 14159 capital (GP), LLC Purchase 4000.0000
2008-01-30 Baker Brothers Life Sciences Capital (GP), LLC Purchase 831000.0000
2008-01-30 Baker Brothers Life Sciences Capital (GP), LLC Purchase 17781000.0000
2008-01-30 Baker / Tisch Capital (GP), LLC Purchase 17000.0000
2008-01-30 Baker / Tisch Capital (GP), LLC Purchase 355000.0000
2008-01-30 14159 capital (GP), LLC Purchase 26000.0000
2008-01-30 14159 capital (GP), LLC Purchase 566000.0000
2008-01-30 Baker Bros. Capital (GP), LLC Purchase 2000.0000
2008-01-30 Baker Bros. Capital (GP), LLC Purchase 48000.0000
2008-07-31 Baker / Tisch Capital (GP), LLC Purchase 4997.0000
2008-07-31 14159 capital (GP), LLC Purchase 27724.0000
2008-07-31 Baker Brothers Life Sciences Capital (GP), LLC Purchase 864092.0000
2008-07-31 Baker Bros. Capital (GP), LLC Purchase 1539.0000
2008-07-31 Baker Biotech Capital (GP), LLC Purchase 201648.0000
2008-10-14 FRIEDMAN PAUL A Purchase 1900.0000
2008-10-14 FRIEDMAN PAUL A Purchase 2800.0000
2008-10-15 FRIEDMAN PAUL A Purchase 5300.0000
2008-11-20 FRIEDMAN PAUL A Purchase 600.0000
2008-11-20 FRIEDMAN PAUL A Purchase 12400.0000
2008-11-20 SCHRECK PATRICIA A Purchase 2500.0000
2008-11-20 HASTINGS DAVID C Purchase 4000.0000
2008-11-20 Chardonnet Laurent Purchase 7700.0000
2008-11-20 Chardonnet Laurent Purchase 300.0000
2008-11-21 METCALF BRIAN W Purchase 3100.0000
2008-11-21 METCALF BRIAN W Purchase 200.0000
2008-11-21 METCALF BRIAN W Purchase 300.0000
2008-11-21 METCALF BRIAN W Purchase 1400.0000
2008-12-17 14159 capital (GP), LLC Purchase 254.0000
2008-12-17 14159 capital (GP), LLC Purchase 2191.0000
2008-12-17 14159 capital (GP), LLC Purchase 3616.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 9259.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 80201.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 132354.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 9259.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 80201.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 132354.0000
2008-12-17 14159 capital (GP), LLC Purchase 254.0000
2008-12-17 14159 capital (GP), LLC Purchase 2191.0000
2008-12-17 14159 capital (GP), LLC Purchase 3616.0000
2008-12-17 Baker / Tisch Capital (GP), LLC Purchase 62.0000
2008-12-17 Baker / Tisch Capital (GP), LLC Purchase 543.0000
2008-12-17 Baker / Tisch Capital (GP), LLC Purchase 896.0000
2008-12-17 Baker Bros. Capital (GP), LLC Purchase 13.0000
2008-12-17 Baker Bros. Capital (GP), LLC Purchase 112.0000
2008-12-17 Baker Bros. Capital (GP), LLC Purchase 184.0000
2008-12-17 Baker Biotech Capital (GP), LLC Purchase 2903.0000
2008-12-17 Baker Biotech Capital (GP), LLC Purchase 25153.0000
2008-12-17 Baker Biotech Capital (GP), LLC Purchase 41510.0000
2008-12-17 Baker / Tisch Capital (GP), LLC Purchase 62.0000
2008-12-17 Baker / Tisch Capital (GP), LLC Purchase 543.0000
2008-12-17 Baker / Tisch Capital (GP), LLC Purchase 896.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 9259.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 80201.0000
2008-12-17 Baker Brothers Life Sciences Capital (GP), LLC Purchase 132354.0000
2008-12-17 14159 capital (GP), LLC Purchase 254.0000
2008-12-17 14159 capital (GP), LLC Purchase 2191.0000
2008-12-17 14159 capital (GP), LLC Purchase 3616.0000
2008-12-17 Baker Bros. Capital (GP), LLC Purchase 13.0000
2008-12-17 Baker Bros. Capital (GP), LLC Purchase 112.0000
2008-12-17 Baker Bros. Capital (GP), LLC Purchase 184.0000
2008-12-17 Baker Biotech Capital (GP), LLC Purchase 2903.0000
2008-12-17 Baker Biotech Capital (GP), LLC Purchase 25153.0000
2008-12-17 Baker Biotech Capital (GP), LLC Purchase 41510.0000
2008-12-18 14159 capital (GP), LLC Purchase 355.0000
2008-12-18 14159 capital (GP), LLC Purchase 5897.0000
2008-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 13055.0000
2008-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 215917.0000
2008-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 13055.0000
2008-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 215917.0000
2008-12-18 14159 capital (GP), LLC Purchase 355.0000
2008-12-18 14159 capital (GP), LLC Purchase 5897.0000
2008-12-18 Baker / Tisch Capital (GP), LLC Purchase 93.0000
2008-12-18 Baker / Tisch Capital (GP), LLC Purchase 1535.0000
2008-12-18 Baker Bros. Capital (GP), LLC Purchase 8.0000
2008-12-18 Baker Bros. Capital (GP), LLC Purchase 125.0000
2008-12-18 Baker Biotech Capital (GP), LLC Purchase 3904.0000
2008-12-18 Baker Biotech Capital (GP), LLC Purchase 64559.0000
2008-12-18 Baker / Tisch Capital (GP), LLC Purchase 93.0000
2008-12-18 Baker / Tisch Capital (GP), LLC Purchase 1535.0000
2008-12-18 Baker / Tisch Capital (GP), LLC Purchase 18000.0000
2008-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 13055.0000
2008-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 215917.0000
2008-12-18 Baker Brothers Life Sciences Capital (GP), LLC Purchase 2436000.0000
2008-12-18 14159 capital (GP), LLC Purchase 355.0000
2008-12-18 14159 capital (GP), LLC Purchase 5897.0000
2008-12-18 14159 capital (GP), LLC Purchase 66000.0000
2008-12-18 Baker Bros. Capital (GP), LLC Purchase 8.0000
2008-12-18 Baker Bros. Capital (GP), LLC Purchase 125.0000
2008-12-18 Baker Bros. Capital (GP), LLC Purchase 1000.0000
2008-12-18 Baker Biotech Capital (GP), LLC Purchase 3904.0000
2008-12-18 Baker Biotech Capital (GP), LLC Purchase 64559.0000
2008-12-18 Baker Biotech Capital (GP), LLC Purchase 729000.0000
2008-12-19 14159 capital (GP), LLC Purchase 1170.0000
2008-12-19 14159 capital (GP), LLC Purchase 6602.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 42834.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 241712.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 42834.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 241712.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 7598000.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 4534000.0000
2008-12-19 14159 capital (GP), LLC Purchase 1170.0000
2008-12-19 14159 capital (GP), LLC Purchase 6602.0000
2008-12-19 14159 capital (GP), LLC Purchase 206000.0000
2008-12-19 14159 capital (GP), LLC Purchase 124000.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 290.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 1637.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 52000.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 31000.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 219.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 1235.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 11000.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 6000.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 13433.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 75808.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 2383000.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 1422000.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 290.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 1637.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 31000.0000
2008-12-19 Baker / Tisch Capital (GP), LLC Purchase 52000.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 42834.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 241712.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 4534000.0000
2008-12-19 Baker Brothers Life Sciences Capital (GP), LLC Purchase 7598000.0000
2008-12-19 14159 capital (GP), LLC Purchase 1170.0000
2008-12-19 14159 capital (GP), LLC Purchase 6602.0000
2008-12-19 14159 capital (GP), LLC Purchase 124000.0000
2008-12-19 14159 capital (GP), LLC Purchase 206000.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 60.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 337.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 6000.0000
2008-12-19 Baker Bros. Capital (GP), LLC Purchase 11000.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 13433.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 75808.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 1422000.0000
2008-12-19 Baker Biotech Capital (GP), LLC Purchase 2383000.0000
2008-12-22 Baker Brothers Life Sciences Capital (GP), LLC Purchase 85.0000
2008-12-22 14159 capital (GP), LLC Purchase 3.0000
2008-12-22 Baker Biotech Capital (GP), LLC Purchase 12.0000
2009-02-26 Baker Brothers Life Sciences Capital (GP), LLC Purchase 7627000.0000
2009-02-26 14159 capital (GP), LLC Purchase 212000.0000
2009-02-26 Baker Brothers Life Sciences Capital (GP), LLC Purchase 7627000.0000
2009-02-26 14159 capital (GP), LLC Purchase 212000.0000
2009-02-26 Baker Biotech Capital (GP), LLC Purchase 1761000.0000
2009-02-26 Baker / Tisch Capital (GP), LLC Purchase 78000.0000
2009-02-26 Baker Bros. Capital (GP), LLC Purchase 4000.0000
2009-02-27 Baker Brothers Life Sciences Capital (GP), LLC Purchase 2993000.0000
2009-02-27 14159 capital (GP), LLC Purchase 83000.0000
2009-02-27 Baker Brothers Life Sciences Capital (GP), LLC Purchase 2993000.0000
2009-02-27 Baker Brothers Life Sciences Capital (GP), LLC Purchase 1969000.0000
2009-02-27 14159 capital (GP), LLC Purchase 83000.0000
2009-02-27 14159 capital (GP), LLC Purchase 55000.0000
2009-02-27 Baker Biotech Capital (GP), LLC Purchase 691000.0000
2009-02-27 Baker Biotech Capital (GP), LLC Purchase 454000.0000
2009-02-27 Baker / Tisch Capital (GP), LLC Purchase 31000.0000
2009-02-27 Baker / Tisch Capital (GP), LLC Purchase 21000.0000
2009-02-27 Baker Bros. Capital (GP), LLC Purchase 2000.0000
2009-02-27 Baker Bros. Capital (GP), LLC Purchase 1000.0000
2009-03-02 Baker Brothers Life Sciences Capital (GP), LLC Purchase 17413.0000
2009-03-02 Baker Brothers Life Sciences Capital (GP), LLC Purchase 15951.0000
2009-03-02 Baker Brothers Life Sciences Capital (GP), LLC Purchase 7878000.0000
2009-03-02 14159 capital (GP), LLC Purchase 484.0000
2009-03-02 14159 capital (GP), LLC Purchase 443.0000
2009-03-02 14159 capital (GP), LLC Purchase 219000.0000
2009-03-02 Baker Brothers Life Sciences Capital (GP), LLC Purchase 17413.0000
2009-03-02 Baker Brothers Life Sciences Capital (GP), LLC Purchase 15951.0000
2009-03-02 Baker Brothers Life Sciences Capital (GP), LLC Purchase 7878000.0000
2009-03-02 14159 capital (GP), LLC Purchase 484.0000
2009-03-02 14159 capital (GP), LLC Purchase 443.0000
2009-03-02 14159 capital (GP), LLC Purchase 219000.0000
2009-03-02 Baker Biotech Capital (GP), LLC Purchase 4019.0000
2009-03-02 Baker Biotech Capital (GP), LLC Purchase 3682.0000
2009-03-02 Baker Biotech Capital (GP), LLC Purchase 1818000.0000
2009-03-02 Baker / Tisch Capital (GP), LLC Purchase 179.0000
2009-03-02 Baker / Tisch Capital (GP), LLC Purchase 164.0000
2009-03-02 Baker / Tisch Capital (GP), LLC Purchase 81000.0000
2009-03-02 Baker Bros. Capital (GP), LLC Purchase 9.0000
2009-03-02 Baker Bros. Capital (GP), LLC Purchase 8.0000
2009-03-02 Baker Bros. Capital (GP), LLC Purchase 4000.0000
2009-03-03 14159 capital (GP), LLC Purchase 264.0000
2009-03-03 14159 capital (GP), LLC Purchase 66000.0000
2009-03-03 Baker Brothers Life Sciences Capital (GP), LLC Purchase 9524.0000
2009-03-03 Baker Brothers Life Sciences Capital (GP), LLC Purchase 2363000.0000
2009-03-03 Baker Bros. Capital (GP), LLC Purchase 5.0000
2009-03-03 Baker Bros. Capital (GP), LLC Purchase 1000.0000
2009-03-03 Baker Biotech Capital (GP), LLC Purchase 2199.0000
2009-03-03 Baker Biotech Capital (GP), LLC Purchase 546000.0000
2009-03-03 Baker / Tisch Capital (GP), LLC Purchase 98.0000
2009-03-03 Baker / Tisch Capital (GP), LLC Purchase 24000.0000
2009-03-03 FRIEDMAN PAUL A Purchase 11160.0000
2009-03-04 14159 capital (GP), LLC Purchase 22000.0000
2009-03-04 Baker Brothers Life Sciences Capital (GP), LLC Purchase 788000.0000
2009-03-04 Baker Biotech Capital (GP), LLC Purchase 182000.0000
2009-03-04 Baker / Tisch Capital (GP), LLC Purchase 8000.0000
2009-03-05 14159 capital (GP), LLC Purchase 312.0000
2009-03-05 14159 capital (GP), LLC Purchase 97000.0000
2009-03-05 14159 capital (GP), LLC Purchase 121000.0000
2009-03-05 Baker Brothers Life Sciences Capital (GP), LLC Purchase 11232.0000
2009-03-05 Baker Brothers Life Sciences Capital (GP), LLC Purchase 3493000.0000
2009-03-05 Baker Brothers Life Sciences Capital (GP), LLC Purchase 4367000.0000
2009-03-05 Baker Bros. Capital (GP), LLC Purchase 5.0000
2009-03-05 Baker Bros. Capital (GP), LLC Purchase 2000.0000
2009-03-05 Baker Bros. Capital (GP), LLC Purchase 2000.0000
2009-03-05 Baker Biotech Capital (GP), LLC Purchase 1248.0000
2009-03-05 Baker Biotech Capital (GP), LLC Purchase 388000.0000
2009-03-05 Baker Biotech Capital (GP), LLC Purchase 485000.0000
2009-03-05 Baker / Tisch Capital (GP), LLC Purchase 64.0000
2009-03-05 Baker / Tisch Capital (GP), LLC Purchase 20000.0000
2009-03-05 Baker / Tisch Capital (GP), LLC Purchase 25000.0000
2009-03-05 FRIEDMAN PAUL A Purchase 8840.0000
2009-03-06 FRIEDMAN PAUL A Purchase 10600.0000
2009-03-09 FRIEDMAN PAUL A Purchase 9400.0000
2010-01-08 Friedman Steven M. Sale 22000.0000
2010-03-15 Levy Richard S Sale 20000.0000
2010-06-17 SWAIN PAULA J Sale 97917.0000
2010-07-01 FRIEDMAN PAUL A Purchase 4303.0000
2010-07-01 FRIEDMAN PAUL A Purchase 5697.0000
2010-07-01 HASTINGS DAVID C Purchase 2000.0000
2010-08-06 SCHRECK PATRICIA A Sale 4505.0000
2010-08-06 SCHRECK PATRICIA A Sale 6200.0000
2010-08-06 SCHRECK PATRICIA A Sale 6000.0000
2010-08-06 SCHRECK PATRICIA A Sale 13430.0000
2010-08-06 SCHRECK PATRICIA A Sale 1499.0000
2010-08-06 SCHRECK PATRICIA A Sale 600.0000
2010-08-06 SCHRECK PATRICIA A Sale 25885.0000
2010-08-06 SCHRECK PATRICIA A Sale 1360.0000
2010-08-06 SCHRECK PATRICIA A Sale 7800.0000
2010-08-06 SCHRECK PATRICIA A Sale 492.0000
2010-08-06 SCHRECK PATRICIA A Sale 7689.0000
2010-08-06 SCHRECK PATRICIA A Sale 10600.0000
2010-08-06 SCHRECK PATRICIA A Sale 8900.0000
2010-08-09 14159 capital (GP), LLC Sale 3907.0000
2010-08-09 14159 capital (GP), LLC Sale 6009.0000
2010-08-09 Baker Brothers Life Sciences Capital (GP), LLC Sale 123602.0000
2010-08-09 Baker Brothers Life Sciences Capital (GP), LLC Sale 190020.0000
2010-08-09 Baker Biotech Capital (GP), LLC Sale 48266.0000
2010-08-09 Baker Biotech Capital (GP), LLC Sale 74201.0000
2010-08-09 Baker / Tisch Capital (GP), LLC Sale 2629.0000
2010-08-09 Baker / Tisch Capital (GP), LLC Sale 4041.0000
2010-08-09 Baker Bros. Capital (GP), LLC Sale 3938.0000
2010-08-09 Baker Bros. Capital (GP), LLC Sale 6053.0000
2010-08-09 Chardonnet Laurent Sale 2500.0000
2010-08-09 Chardonnet Laurent Sale 2200.0000
2010-08-09 Chardonnet Laurent Sale 9818.0000
2010-08-09 Chardonnet Laurent Sale 1100.0000
2010-08-10 14159 capital (GP), LLC Sale 947.0000
2010-08-10 14159 capital (GP), LLC Sale 1842.0000
2010-08-10 Baker Brothers Life Sciences Capital (GP), LLC Sale 29988.0000
2010-08-10 Baker Brothers Life Sciences Capital (GP), LLC Sale 58262.0000
2010-08-10 Baker Biotech Capital (GP), LLC Sale 11711.0000
2010-08-10 Baker Biotech Capital (GP), LLC Sale 22751.0000
2010-08-10 Baker / Tisch Capital (GP), LLC Sale 638.0000
2010-08-10 Baker / Tisch Capital (GP), LLC Sale 1239.0000
2010-08-10 Baker Bros. Capital (GP), LLC Sale 956.0000
2010-08-10 Baker Bros. Capital (GP), LLC Sale 1856.0000
2010-09-21 Baker Brothers Life Sciences Capital (GP), LLC Sale 610072.0000
2010-09-21 Baker / Tisch Capital (GP), LLC Sale 12974.0000
2010-09-21 Baker Bros. Capital (GP), LLC Sale 19433.0000
2010-09-21 Baker Biotech Capital (GP), LLC Sale 238230.0000
2010-09-21 14159 capital (GP), LLC Sale 19291.0000
2010-09-22 Baker Brothers Life Sciences Capital (GP), LLC Sale 227071.0000
2010-09-22 Baker / Tisch Capital (GP), LLC Sale 4829.0000
2010-09-22 Baker Bros. Capital (GP), LLC Sale 7233.0000
2010-09-22 Baker Biotech Capital (GP), LLC Sale 88670.0000
2010-09-22 14159 capital (GP), LLC Sale 7180.0000
2010-09-23 Baker Brothers Life Sciences Capital (GP), LLC Sale 179644.0000
2010-09-23 Baker / Tisch Capital (GP), LLC Sale 3820.0000
2010-09-23 Baker Bros. Capital (GP), LLC Sale 5722.0000
2010-09-23 Baker Biotech Capital (GP), LLC Sale 70150.0000
2010-09-23 14159 capital (GP), LLC Sale 5681.0000
2010-10-22 WHITFIELD ROY A Sale 4730.0000
2010-10-25 WHITFIELD ROY A Sale 153.0000
2010-10-25 WHITFIELD ROY A Sale 1000.0000
2010-10-25 WHITFIELD ROY A Sale 2900.0000
2010-10-25 WHITFIELD ROY A Sale 300.0000
2010-10-25 WHITFIELD ROY A Sale 600.0000
2010-10-25 WHITFIELD ROY A Sale 4400.0000
2010-10-25 WHITFIELD ROY A Sale 300.0000
2010-10-25 WHITFIELD ROY A Sale 200.0000
2010-10-25 WHITFIELD ROY A Sale 4055.0000
2010-10-25 WHITFIELD ROY A Sale 3915.0000
2010-10-25 WHITFIELD ROY A Sale 5400.0000
2010-10-25 WHITFIELD ROY A Sale 3600.0000
2010-10-25 WHITFIELD ROY A Sale 2700.0000
2010-11-16 WHITFIELD ROY A Sale 6541.0000
2010-11-16 WHITFIELD ROY A Sale 2759.0000
2010-11-16 WHITFIELD ROY A Sale 700.0000
2010-11-17 WHITFIELD ROY A Sale 1000.0000
2010-12-22 WHITFIELD ROY A Sale 10000.0000
2010-12-23 WHITFIELD ROY A Sale 8100.0000
2010-12-23 WHITFIELD ROY A Sale 400.0000
2010-12-23 WHITFIELD ROY A Sale 100.0000
2010-12-23 WHITFIELD ROY A Sale 500.0000
2010-12-23 WHITFIELD ROY A Sale 400.0000
2010-12-23 WHITFIELD ROY A Sale 400.0000
2010-12-23 WHITFIELD ROY A Sale 100.0000
2011-01-18 Levy Richard S Sale 616.0000
2011-01-18 Levy Richard S Sale 1494.0000
2011-01-18 Levy Richard S Sale 8200.0000
2011-01-18 Levy Richard S Sale 13600.0000
2011-01-18 Levy Richard S Sale 10000.0000
2011-01-18 Levy Richard S Sale 6400.0000
2011-02-15 14159 capital (GP), LLC Purchase 206000.0000
2011-02-15 14159 capital (GP), LLC Purchase 124000.0000
2011-02-15 Baker Brothers Life Sciences Capital (GP), LLC Purchase 7598000.0000
2011-02-15 Baker Brothers Life Sciences Capital (GP), LLC Purchase 4534000.0000
2011-02-17 METCALF BRIAN W Sale 50000.0000
2011-03-10 DE SCHUTTER RICHARD U Purchase 150000.0000
2011-03-16 METCALF BRIAN W Sale 50000.0000
2011-03-18 METCALF BRIAN W Sale 50000.0000
2011-03-18 METCALF BRIAN W Sale 58300.0000
2011-03-18 METCALF BRIAN W Sale 51500.0000
2011-03-18 METCALF BRIAN W Sale 200.0000
2011-03-25 WHITFIELD ROY A Sale 2700.0000
2011-03-25 WHITFIELD ROY A Sale 1500.0000
2011-03-25 WHITFIELD ROY A Sale 1300.0000
2011-03-25 WHITFIELD ROY A Sale 1500.0000
2011-03-25 WHITFIELD ROY A Sale 400.0000
2011-03-25 WHITFIELD ROY A Sale 200.0000
2011-03-25 WHITFIELD ROY A Sale 100.0000
2011-03-25 WHITFIELD ROY A Sale 300.0000
2011-03-25 WHITFIELD ROY A Sale 100.0000
2011-03-25 WHITFIELD ROY A Sale 500.0000
2011-03-25 WHITFIELD ROY A Sale 600.0000
2011-03-25 WHITFIELD ROY A Sale 100.0000
2011-03-25 WHITFIELD ROY A Sale 700.0000
2011-04-05 WHITFIELD ROY A Sale 300.0000
2011-04-05 WHITFIELD ROY A Sale 7700.0000
2011-04-05 WHITFIELD ROY A Sale 1400.0000
2011-04-05 WHITFIELD ROY A Sale 200.0000
2011-04-05 WHITFIELD ROY A Sale 400.0000
2011-04-07 SCHRECK PATRICIA A Sale 100000.0000
2011-04-08 Chardonnet Laurent Sale 21194.0000
2011-04-08 Chardonnet Laurent Sale 200.0000
2011-04-08 Chardonnet Laurent Sale 2900.0000
2011-04-08 Chardonnet Laurent Sale 100.0000
2011-04-08 Chardonnet Laurent Sale 506.0000
2011-04-08 Chardonnet Laurent Sale 100.0000
2011-04-11 METCALF BRIAN W Sale 50000.0000
2011-04-11 METCALF BRIAN W Sale 50000.0000
2011-05-05 WHITFIELD ROY A Sale 2800.0000
2011-05-05 WHITFIELD ROY A Sale 1700.0000
2011-05-05 WHITFIELD ROY A Sale 610.0000
2011-05-05 WHITFIELD ROY A Sale 300.0000
2011-05-05 WHITFIELD ROY A Sale 1500.0000
2011-05-05 WHITFIELD ROY A Sale 2990.0000
2011-05-05 WHITFIELD ROY A Sale 100.0000
2011-05-06 Chardonnet Laurent Sale 5343.0000
2011-05-09 WHITFIELD ROY A Sale 1400.0000
2011-05-09 WHITFIELD ROY A Sale 900.0000
2011-05-09 WHITFIELD ROY A Sale 800.0000
2011-05-09 WHITFIELD ROY A Sale 316.0000
2011-05-09 WHITFIELD ROY A Sale 2184.0000
2011-05-09 WHITFIELD ROY A Sale 100.0000
2011-05-09 WHITFIELD ROY A Sale 4300.0000
2011-05-09 SCHRECK PATRICIA A Sale 50000.0000
2011-05-10 SCHRECK PATRICIA A Sale 10000.0000
2011-05-10 SCHRECK PATRICIA A Sale 10000.0000
2011-05-10 SCHRECK PATRICIA A Sale 10000.0000
2011-05-10 SCHRECK PATRICIA A Sale 10000.0000
2011-05-10 SCHRECK PATRICIA A Sale 10000.0000
2011-05-11 WHITFIELD ROY A Sale 2200.0000
2011-05-11 WHITFIELD ROY A Sale 3702.0000
2011-05-11 WHITFIELD ROY A Sale 1798.0000
2011-05-11 WHITFIELD ROY A Sale 600.0000
2011-05-11 WHITFIELD ROY A Sale 1700.0000
2011-05-12 WHITFIELD ROY A Sale 300.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 200.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 400.0000
2011-05-12 WHITFIELD ROY A Sale 200.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 200.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 100.0000
2011-05-12 WHITFIELD ROY A Sale 3399.0000
2011-05-12 WHITFIELD ROY A Sale 200.0000
2011-05-12 WHITFIELD ROY A Sale 3203.0000
2011-05-12 WHITFIELD ROY A Sale 268.0000
2011-05-12 WHITFIELD ROY A Sale 30.0000
2011-05-12 WHITFIELD ROY A Sale 200.0000
2011-05-17 SWAIN PAULA J Sale 23301.0000
2011-05-17 SWAIN PAULA J Sale 26699.0000
2011-05-17 SWAIN PAULA J Sale 25000.0000
2011-06-09 HASTINGS DAVID C Sale 25000.0000
2011-06-09 HASTINGS DAVID C Sale 25000.0000
2011-06-09 HASTINGS DAVID C Sale 25000.0000
2011-06-09 HASTINGS DAVID C Sale 25000.0000
2011-06-16 WHITFIELD ROY A Sale 1000.0000
2011-06-16 WHITFIELD ROY A Sale 1102.0000
2011-06-16 WHITFIELD ROY A Sale 900.0000
2011-06-16 WHITFIELD ROY A Sale 900.0000
2011-06-16 WHITFIELD ROY A Sale 600.0000
2011-06-17 WHITFIELD ROY A Sale 4700.0000
2011-06-17 WHITFIELD ROY A Sale 2400.0000
2011-06-17 WHITFIELD ROY A Sale 2100.0000
2011-06-17 WHITFIELD ROY A Sale 1579.0000
2011-06-17 WHITFIELD ROY A Sale 1498.0000
2011-06-17 WHITFIELD ROY A Sale 1000.0000
2011-06-17 WHITFIELD ROY A Sale 1321.0000
2011-06-17 WHITFIELD ROY A Sale 500.0000
2011-06-17 WHITFIELD ROY A Sale 400.0000
2011-06-21 Chardonnet Laurent Sale 18062.0000
2011-06-21 Chardonnet Laurent Sale 5500.0000
2011-06-21 Chardonnet Laurent Sale 100.0000
2011-06-21 Chardonnet Laurent Sale 100.0000
2011-06-21 Chardonnet Laurent Sale 2938.0000
2011-06-21 Chardonnet Laurent Sale 700.0000
2011-06-21 Chardonnet Laurent Sale 2700.0000
2011-06-21 Chardonnet Laurent Sale 1100.0000
2011-06-21 Chardonnet Laurent Sale 100.0000
2011-06-21 Chardonnet Laurent Sale 100.0000
2011-06-21 Chardonnet Laurent Sale 200.0000
2011-06-21 Chardonnet Laurent Sale 300.0000
2011-06-21 Chardonnet Laurent Sale 7900.0000
2011-06-21 Chardonnet Laurent Sale 200.0000
2011-08-12 DE SCHUTTER RICHARD U Purchase 225000.0000
2011-11-17 DIXON WENDY L Purchase 585.0000
2011-11-17 DIXON WENDY L Purchase 700.0000
2011-11-17 DIXON WENDY L Purchase 2338.0000
2011-11-17 DIXON WENDY L Purchase 3877.0000
2011-11-29 Baker Brothers Life Sciences Capital (GP), LLC Purchase 486969.0000
2011-11-29 Baker Brothers Life Sciences Capital (GP), LLC Purchase 582677.0000
2011-11-29 14159 capital (GP), LLC Purchase 13153.0000
2011-11-29 14159 capital (GP), LLC Purchase 15737.0000
2011-11-30 Baker Brothers Life Sciences Capital (GP), LLC Purchase 250000.0000
2011-11-30 Baker Brothers Life Sciences Capital (GP), LLC Purchase 257911.0000
2011-12-01 Baker Brothers Life Sciences Capital (GP), LLC Purchase 243425.0000
2011-12-01 Baker Brothers Life Sciences Capital (GP), LLC Purchase 317429.0000
2011-12-01 Baker Brothers Life Sciences Capital (GP), LLC Purchase 267768.0000
2011-12-01 14159 capital (GP), LLC Purchase 6575.0000
2011-12-01 14159 capital (GP), LLC Purchase 8573.0000
2011-12-01 14159 capital (GP), LLC Purchase 7232.0000
2011-12-05 Baker Brothers Life Sciences Capital (GP), LLC Purchase 1023128.0000
2011-12-05 Baker Brothers Life Sciences Capital (GP), LLC Purchase 48697.0000
2011-12-05 14159 capital (GP), LLC Purchase 27382.0000
2011-12-05 14159 capital (GP), LLC Purchase 1303.0000
2011-12-06 Baker Brothers Life Sciences Capital (GP), LLC Purchase 192316.0000
2011-12-06 Baker Brothers Life Sciences Capital (GP), LLC Purchase 146090.0000
2011-12-06 14159 capital (GP), LLC Purchase 5147.0000
2011-12-06 14159 capital (GP), LLC Purchase 3910.0000
2011-12-07 Baker Brothers Life Sciences Capital (GP), LLC Purchase 75948.0000
2011-12-07 Baker Brothers Life Sciences Capital (GP), LLC Purchase 68955.0000
2011-12-07 14159 capital (GP), LLC Purchase 2033.0000
2011-12-07 14159 capital (GP), LLC Purchase 1845.0000
2011-12-08 14159 capital (GP), LLC Purchase 4291.0000
2011-12-08 14159 capital (GP), LLC Purchase 1674.0000
2011-12-08 Baker Brothers Life Sciences Capital (GP), LLC Purchase 159925.0000
2011-12-08 Baker Brothers Life Sciences Capital (GP), LLC Purchase 62395.0000
2011-12-09 14159 capital (GP), LLC Purchase 73.0000
2011-12-09 14159 capital (GP), LLC Purchase 4789.0000
2011-12-09 Baker Brothers Life Sciences Capital (GP), LLC Purchase 2727.0000
2011-12-09 Baker Brothers Life Sciences Capital (GP), LLC Purchase 178474.0000
2012-01-12 Baker Brothers Life Sciences Capital (GP), LLC Purchase 105847.0000
2012-01-12 Baker Brothers Life Sciences Capital (GP), LLC Purchase 219881.0000
2012-01-12 14159 capital (GP), LLC Purchase 2850.0000
2012-01-12 14159 capital (GP), LLC Purchase 5919.0000
2012-01-13 Baker Brothers Life Sciences Capital (GP), LLC Purchase 102856.0000
2012-01-13 Baker Brothers Life Sciences Capital (GP), LLC Purchase 72978.0000
2012-01-13 Baker Brothers Life Sciences Capital (GP), LLC Purchase 41677.0000
2012-01-13 14159 capital (GP), LLC Purchase 2769.0000
2012-01-13 14159 capital (GP), LLC Purchase 1965.0000
2012-01-13 14159 capital (GP), LLC Purchase 1122.0000
2012-01-18 BROOKE PAUL A Purchase 25000.0000
2012-01-19 BROOKE PAUL A Purchase 25000.0000
2012-02-17 WHITFIELD ROY A Sale 2300.0000
2012-02-17 WHITFIELD ROY A Sale 600.0000
2012-02-17 WHITFIELD ROY A Sale 1200.0000
2012-02-17 WHITFIELD ROY A Sale 7000.0000
2012-02-17 WHITFIELD ROY A Sale 3600.0000
2012-02-17 WHITFIELD ROY A Sale 4600.0000
2012-02-17 WHITFIELD ROY A Sale 700.0000
2012-04-27 Levy Richard S Sale 30000.0000
2012-05-01 Chardonnet Laurent Sale 13976.0000
2012-05-07 FRIEDMAN PAUL A Sale 225000.0000
2012-05-11 SWAIN PAULA J Sale 147389.0000
2012-05-14 Siegel Eric H. Sale 56666.0000
2012-05-14 Siegel Eric H. Sale 100.0000
2012-05-14 Siegel Eric H. Sale 715.0000
2012-05-16 BROOKE PAUL A Sale 5000.0000
2012-05-24 WHITFIELD ROY A Sale 20000.0000
2012-07-02 Chardonnet Laurent Sale 36666.0000
2012-07-05 Chardonnet Laurent Sale 5586.0000
2012-07-05 Chardonnet Laurent Sale 27300.0000
2012-07-05 Chardonnet Laurent Sale 2214.0000
2012-07-05 Chardonnet Laurent Sale 600.0000
2012-12-17 DE SCHUTTER RICHARD U Sale 50000.0000
2012-12-17 DE SCHUTTER RICHARD U Purchase 45000.0000
2013-02-15 HASTINGS DAVID C Sale 100000.0000
2013-02-15 Levy Richard S Sale 98440.0000
2013-02-19 WHITFIELD ROY A Sale 30000.0000
2013-02-20 SWAIN PAULA J Sale 103283.0000
2013-02-28 Siegel Eric H. Sale 50000.0000
2013-03-01 WHITFIELD ROY A Sale 10000.0000
2013-03-14 WHITFIELD ROY A Sale 10000.0000
2013-05-13 Levy Richard S Sale 55699.0000
2013-05-17 WHITFIELD ROY A Sale 40000.0000
2013-08-19 WHITFIELD ROY A Sale 50000.0000
2013-09-05 SWAIN PAULA J Sale 94444.0000
2013-09-05 Chardonnet Laurent Sale 8767.0000
2013-09-06 Levy Richard S Sale 25000.0000
2013-09-06 Siegel Eric H. Sale 55978.0000
2013-09-06 HASTINGS DAVID C Sale 100000.0000
2013-09-09 Chardonnet Laurent Sale 36067.0000
2013-09-10 FRIEDMAN PAUL A Sale 376789.0000
2013-11-08 BAKER JULIAN Purchase 25000000.0000
2013-11-08 BAKER JULIAN Purchase 219544000.0000
2013-11-08 BAKER JULIAN Purchase 5456000.0000
2013-11-08 BAKER JULIAN Purchase 3415000.0000
2013-11-08 BAKER JULIAN Purchase 85000.0000
2013-11-08 BAKER JULIAN Purchase 5367000.0000
2013-11-08 BAKER JULIAN Purchase 133000.0000
2013-11-08 BAKER JULIAN Purchase 25000000.0000
2013-11-08 BAKER JULIAN Purchase 219544000.0000
2013-11-08 BAKER JULIAN Purchase 5456000.0000
2013-11-08 BAKER JULIAN Purchase 4879000.0000
2013-11-08 BAKER JULIAN Purchase 121000.0000
2013-11-08 BAKER JULIAN Purchase 2439000.0000
2013-11-08 BAKER JULIAN Purchase 61000.0000
2013-11-08 BAKER JULIAN Purchase 9758000.0000
2013-11-08 BAKER JULIAN Purchase 242000.0000
2013-11-08 BAKER JULIAN Purchase 6830000.0000
2013-11-08 BAKER JULIAN Purchase 170000.0000
2013-11-18 WHITFIELD ROY A Sale 50000.0000
2014-02-13 Daly James M Sale 158331.0000
2014-02-13 Levy Richard S Sale 191309.0000
2014-02-13 HASTINGS DAVID C Sale 202999.0000
2014-02-13 Chardonnet Laurent Sale 98334.0000
2014-02-13 Siegel Eric H. Sale 54855.0000
2014-02-13 Siegel Eric H. Sale 1187.0000
2014-02-13 SWAIN PAULA J Sale 216967.0000
2014-02-13 ARIKO BARRY A Sale 10000.0000
2014-02-14 Levy Richard S Sale 39787.0000
2014-02-14 HASTINGS DAVID C Sale 40000.0000
2014-02-14 FRIEDMAN PAUL A Sale 10227.0000
2014-02-18 HASTINGS DAVID C Sale 32001.0000
2014-02-18 FRIEDMAN PAUL A Sale 720036.0000
2014-02-18 DE SCHUTTER RICHARD U Sale 42545.0000
2014-02-19 FRIEDMAN PAUL A Sale 40919.0000
2014-02-19 DE SCHUTTER RICHARD U Sale 7455.0000
2014-02-20 FRIEDMAN PAUL A Sale 33354.0000
2014-04-23 Daly James M Sale 30555.0000
2014-05-02 Chardonnet Laurent Sale 34000.0000
2014-05-12 Chardonnet Laurent Sale 2058.0000
2014-05-16 Levy Richard S Sale 8000.0000
2014-05-23 Daly James M Sale 11111.0000
2014-06-04 HASTINGS DAVID C Sale 76034.0000
2014-06-05 HASTINGS DAVID C Sale 123966.0000
2014-06-16 Levy Richard S Sale 8000.0000
2014-06-23 Daly James M Sale 2777.0000
2014-06-23 Daly James M Sale 8334.0000
2014-07-16 Levy Richard S Sale 8000.0000
2014-07-23 Daly James M Sale 11111.0000
2014-08-18 Levy Richard S Sale 8000.0000
2014-08-25 Daly James M Sale 11111.0000
2014-09-16 Levy Richard S Sale 8000.0000
2014-09-23 Daly James M Sale 11111.0000
2014-10-16 Levy Richard S Sale 8000.0000
2014-10-23 Daly James M Sale 11111.0000
2014-11-06 FRIEDMAN PAUL A Sale 185653.0000
2014-11-17 Levy Richard S Sale 12000.0000
2014-11-24 Daly James M Sale 11111.0000
2014-12-01 DE SCHUTTER RICHARD U Sale 2200.0000
2014-12-02 DE SCHUTTER RICHARD U Sale 47800.0000
2014-12-16 Levy Richard S Sale 12000.0000
2014-12-23 Daly James M Sale 11113.0000
2015-01-05 SWAIN PAULA J Sale 17500.0000
2015-01-06 Levy Richard S Sale 25000.0000
2015-01-08 Siegel Eric H. Sale 15626.0000
2015-01-16 Levy Richard S Sale 12000.0000
2015-01-20 SWAIN PAULA J Sale 17500.0000
2015-01-22 Siegel Eric H. Sale 1042.0000
2015-01-23 Siegel Eric H. Sale 11458.0000
2015-01-23 Daly James M Sale 11109.0000
2015-01-26 Siegel Eric H. Sale 1042.0000
2015-02-06 Levy Richard S Sale 25000.0000
2015-02-13 FRIEDMAN PAUL A Sale 60000.0000
2015-02-13 FRIEDMAN PAUL A Sale 60000.0000
2015-02-17 SWAIN PAULA J Sale 17500.0000
2015-02-17 Levy Richard S Sale 12000.0000
2015-02-18 ARIKO BARRY A Sale 20000.0000
2015-02-23 Daly James M Sale 2778.0000
2015-02-24 Daly James M Sale 8334.0000
2015-02-25 Siegel Eric H. Sale 13333.0000
2015-03-05 DE SCHUTTER RICHARD U Sale 32469.0000
2015-03-05 DE SCHUTTER RICHARD U Sale 7531.0000
2015-03-05 Siegel Eric H. Sale 13333.0000
2015-03-06 Levy Richard S Sale 25000.0000
2015-03-12 Siegel Eric H. Sale 1111.0000
2015-03-12 Siegel Eric H. Sale 1111.0000
2015-03-12 ARIKO BARRY A Sale 80000.0000
2015-03-16 SWAIN PAULA J Sale 17500.0000
2015-03-30 Huber Reid M Sale 10000.0000
2015-03-30 Huber Reid M Sale 8000.0000
2015-03-30 Huber Reid M Sale 7000.0000
2015-03-30 Huber Reid M Sale 5000.0000
2015-03-30 Huber Reid M Sale 4263.0000
2015-03-30 Chardonnet Laurent Sale 46000.0000
2015-03-30 Chardonnet Laurent Sale 40000.0000
2015-03-30 Chardonnet Laurent Sale 27776.0000
2015-04-06 Levy Richard S Sale 25000.0000
2015-04-07 Wenqing Yao Sale 5000.0000
2015-04-07 Wenqing Yao Sale 1853.0000
2015-04-07 Wenqing Yao Sale 3178.0000
2015-04-07 Wenqing Yao Sale 5000.0000
2015-04-07 Wenqing Yao Sale 5000.0000
2015-04-10 Wenqing Yao Sale 9000.0000
2015-04-13 Wenqing Yao Sale 14000.0000
2015-04-13 SWAIN PAULA J Sale 16469.0000
2015-04-14 Siegel Eric H. Sale 1111.0000
2015-04-14 Siegel Eric H. Sale 1111.0000
2015-04-17 Wenqing Yao Sale 7150.0000
2015-04-23 Daly James M Sale 22223.0000
2015-04-23 Daly James M Sale 14718.0000
2015-05-06 Levy Richard S Sale 7412.0000
2015-05-14 Siegel Eric H. Sale 2222.0000
2015-05-21 FRIEDMAN PAUL A Sale 8263.0000
2015-05-21 FRIEDMAN PAUL A Sale 14388.0000
2015-05-22 FRIEDMAN PAUL A Sale 14392.0000
2015-05-22 FRIEDMAN PAUL A Sale 15200.0000
2015-05-22 FRIEDMAN PAUL A Sale 25000.0000
2015-05-22 FRIEDMAN PAUL A Sale 25000.0000
2015-05-26 Daly James M Sale 11112.0000
2015-05-26 Daly James M Sale 981.0000
2015-05-26 FRIEDMAN PAUL A Sale 2619.0000
2015-05-26 FRIEDMAN PAUL A Sale 50000.0000
2015-05-26 FRIEDMAN PAUL A Sale 2358.0000
2015-05-26 FRIEDMAN PAUL A Sale 50000.0000
2015-05-26 FRIEDMAN PAUL A Sale 22642.0000
2015-05-27 FRIEDMAN PAUL A Sale 52696.0000
2015-05-27 FRIEDMAN PAUL A Sale 16436.0000
2015-06-08 Levy Richard S Sale 3937.0000
2015-06-12 Siegel Eric H. Sale 2223.0000
2015-06-19 Levy Richard S Sale 20000.0000
2015-06-23 Daly James M Sale 10710.0000
2015-06-23 Daly James M Sale 981.0000
2015-07-06 Levy Richard S Sale 3937.0000
2015-07-14 Siegel Eric H. Sale 2222.0000
2015-07-14 Wenqing Yao Sale 7850.0000
2015-07-15 Levy Richard S Sale 70217.0000
2015-07-15 Wenqing Yao Sale 5000.0000
2015-08-06 Levy Richard S Sale 3936.0000
2015-08-13 Siegel Eric H. Sale 2222.0000
2015-09-08 Levy Richard S Sale 3937.0000
2015-09-11 Levy Richard S Sale 4301.0000
2015-09-16 Siegel Eric H. Sale 2222.0000
2015-09-21 Huber Reid M Sale 10000.0000
2015-10-06 Levy Richard S Sale 3937.0000
2015-10-13 Siegel Eric H. Sale 2222.0000
2015-11-03 Wenqing Yao Sale 786.0000
2015-11-03 Wenqing Yao Sale 5000.0000
2015-11-06 Levy Richard S Sale 3936.0000
2015-11-10 Siegel Eric H. Sale 2222.0000
2015-11-17 FRIEDMAN PAUL A Sale 7052.0000
2015-11-17 FRIEDMAN PAUL A Sale 42948.0000
2015-11-17 FRIEDMAN PAUL A Sale 50000.0000
2015-11-18 FRIEDMAN PAUL A Sale 86132.0000
2015-11-18 FRIEDMAN PAUL A Sale 38868.0000
2015-12-07 Levy Richard S Sale 3937.0000
2015-12-10 Siegel Eric H. Sale 1936.0000
2016-01-06 Levy Richard S Sale 3937.0000
2016-01-15 SWAIN PAULA J Sale 13531.0000
2016-02-11 BAKER JULIAN Purchase 25869.0000
2016-02-11 BAKER JULIAN Purchase 235734.0000
2016-02-11 BAKER JULIAN Purchase 19383.0000
2016-02-11 BAKER JULIAN Purchase 176647.0000
2016-02-11 BAKER JULIAN Purchase 31795.0000
2016-02-11 BAKER JULIAN Purchase 289755.0000
2016-02-11 BAKER JULIAN Purchase 12459.0000
2016-02-11 BAKER JULIAN Purchase 113546.0000
2016-02-11 BAKER JULIAN Purchase 7166.0000
2016-02-11 BAKER JULIAN Purchase 65309.0000
2016-02-11 BAKER JULIAN Purchase 12609.0000
2016-02-11 BAKER JULIAN Purchase 114908.0000
2016-02-11 BAKER JULIAN Purchase 15010.0000
2016-02-11 BAKER JULIAN Purchase 136793.0000
2016-02-11 BAKER JULIAN Purchase 6349.0000
2016-02-11 BAKER JULIAN Purchase 57865.0000
2016-02-11 BAKER JULIAN Purchase 761.0000
2016-02-11 BAKER JULIAN Purchase 6939.0000
2016-02-12 BAKER JULIAN Purchase 7999.0000
2016-02-12 BAKER JULIAN Purchase 72894.0000
2016-02-12 BAKER JULIAN Purchase 5379.0000
2016-02-12 BAKER JULIAN Purchase 49021.0000
2016-02-12 BAKER JULIAN Purchase 59401.0000
2016-02-12 BAKER JULIAN Purchase 541340.0000
2016-02-12 BAKER JULIAN Purchase 18441.0000
2016-02-12 BAKER JULIAN Purchase 168055.0000
2016-02-12 BAKER JULIAN Purchase 4183.0000
2016-02-12 BAKER JULIAN Purchase 38117.0000
2016-02-12 BAKER JULIAN Purchase 16450.0000
2016-02-12 BAKER JULIAN Purchase 149927.0000
2016-02-16 BAKER JULIAN Purchase 43178.0000
2016-02-16 BAKER JULIAN Purchase 397079.0000
2016-02-16 BAKER JULIAN Purchase 13490.0000
2016-02-16 BAKER JULIAN Purchase 124057.0000
2016-02-16 BAKER JULIAN Purchase 7326.0000
2016-02-16 BAKER JULIAN Purchase 67373.0000
2016-02-16 BAKER JULIAN Purchase 897.0000
2016-02-16 BAKER JULIAN Purchase 8250.0000
2016-02-16 BAKER JULIAN Purchase 1651.0000
2016-02-16 BAKER JULIAN Purchase 15187.0000
2016-02-24 BAKER JULIAN Purchase 914.0000
2016-02-24 BAKER JULIAN Purchase 8111.0000
2016-02-24 BAKER JULIAN Purchase 2608.0000
2016-02-24 BAKER JULIAN Purchase 23157.0000
2016-02-24 BAKER JULIAN Purchase 2308.0000
2016-02-24 BAKER JULIAN Purchase 20492.0000
2016-02-25 BAKER JULIAN Purchase 678.0000
2016-02-25 BAKER JULIAN Purchase 6022.0000
2016-03-15 BAKER JULIAN Purchase 19642.0000
2016-03-15 BAKER JULIAN Purchase 180358.0000
2016-03-15 BAKER JULIAN Purchase 19513.0000
2016-03-15 BAKER JULIAN Purchase 179176.0000
2016-03-15 BAKER JULIAN Purchase 129.0000
2016-03-15 BAKER JULIAN Purchase 1182.0000
2016-03-17 BAKER JULIAN Purchase 10616.0000
2016-03-17 BAKER JULIAN Purchase 97484.0000
2016-03-17 BAKER JULIAN Purchase 2250.0000
2016-03-17 BAKER JULIAN Purchase 20659.0000
2016-03-17 BAKER JULIAN Purchase 2660.0000
2016-03-17 BAKER JULIAN Purchase 24431.0000
2016-03-17 BAKER JULIAN Purchase 13936.0000
2016-03-17 BAKER JULIAN Purchase 127964.0000
2016-03-17 BAKER JULIAN Purchase 9821.0000
2016-03-17 BAKER JULIAN Purchase 90179.0000
2016-07-29 SWAIN PAULA J Sale 60000.0000
2016-08-02 Huber Reid M Sale 10000.0000
2016-09-23 SWAIN PAULA J Sale 20000.0000
2016-10-07 Flannelly Barry P Sale 24204.0000
2016-10-07 Huber Reid M Sale 11709.0000
2016-10-20 SWAIN PAULA J Sale 10000.0000
2016-11-09 Huber Reid M Sale 2715.0000
2016-11-15 SWAIN PAULA J Sale 10000.0000
2017-01-09 Huber Reid M Sale 11739.0000
2017-02-23 FRIEDMAN PAUL A Sale 50000.0000
2017-02-27 Huber Reid M Sale 2008.0000
2017-03-16 FRIEDMAN PAUL A Sale 8307.0000
2017-03-17 FRIEDMAN PAUL A Sale 41693.0000
2017-03-17 BROOKE PAUL A Sale 20000.0000
2017-04-07 BIENAIME JEAN JACQUES Purchase 1000.0000
2017-04-07 Stein Steven H Sale 27000.0000
2017-04-07 Stein Steven H Sale 5000.0000
2017-04-10 GRYSKA DAVID W Sale 1739.0000
2017-04-10 GRYSKA DAVID W Sale 39789.0000
2017-04-10 Siegel Eric H. Sale 2223.0000
2017-04-10 Siegel Eric H. Sale 1820.0000
2017-04-13 BIENAIME JEAN JACQUES Purchase 1000.0000
2017-04-28 BIENAIME JEAN JACQUES Purchase 500.0000
2017-04-28 GRYSKA DAVID W Sale 1389.0000
2017-05-01 Siegel Eric H. Sale 1820.0000
2017-05-01 Flannelly Barry P Sale 803.0000
2017-05-01 Flannelly Barry P Sale 4493.0000
2017-05-05 Trower Paul Sale 3000.0000
2017-05-08 Huber Reid M Sale 8577.0000
2017-05-15 BIENAIME JEAN JACQUES Purchase 500.0000
2017-05-31 BIENAIME JEAN JACQUES Purchase 500.0000
2017-06-01 Siegel Eric H. Sale 1820.0000
2017-06-05 Trower Paul Sale 3000.0000
2017-06-12 GRYSKA DAVID W Sale 16756.0000
2017-06-20 Stein Steven H Sale 3870.0000
2017-06-20 Stein Steven H Sale 6013.0000
2017-06-30 GRYSKA DAVID W Sale 599.0000
2017-07-03 Siegel Eric H. Sale 1820.0000
2017-07-05 Trower Paul Sale 3000.0000
2017-07-20 Stein Steven H Sale 1191.0000
2017-07-20 Stein Steven H Sale 4772.0000
2017-07-20 Stein Steven H Sale 522.0000
2017-08-01 Siegel Eric H. Sale 1820.0000
2017-08-04 Trower Paul Sale 3000.0000
2017-08-29 Stein Steven H Sale 522.0000
2017-08-29 Stein Steven H Sale 1192.0000
2017-08-29 Stein Steven H Sale 397.0000
2017-08-31 SWAIN PAULA J Sale 20000.0000
2017-09-01 Siegel Eric H. Sale 1820.0000
2017-09-05 Trower Paul Sale 3000.0000
2017-09-08 BAKER BROS. ADVISORS LP Purchase 12569.0000
2017-09-08 BAKER BROS. ADVISORS LP Purchase 85402.0000
2017-09-08 BAKER BROS. ADVISORS LP Purchase 2029.0000
2017-09-14 Flannelly Barry P Sale 714.0000
2017-09-18 Hoppenot Herve Sale 70502.0000
2017-11-02 GRYSKA DAVID W Sale 3915.0000
2017-11-16 FRIEDMAN PAUL A Sale 28507.0000
2017-12-01 Huber Reid M Sale 696.0000
2018-01-02 Iyengar Vijay K Sale 5000.0000
2018-01-05 GRYSKA DAVID W Sale 6760.0000
2018-02-21 Huber Reid M Sale 1958.0000
2018-02-21 GRYSKA DAVID W Sale 1952.0000
2018-04-30 SWAIN PAULA J Sale 6100.0000
2018-04-30 SWAIN PAULA J Sale 73900.0000
2018-05-02 Hoppenot Herve Purchase 15000.0000
2018-07-09 Iyengar Vijay K Sale 606.0000
2018-07-09 SWAIN PAULA J Sale 10000.0000
2018-08-21 SWAIN PAULA J Sale 10000.0000
2018-09-04 SWAIN PAULA J Sale 10000.0000
2018-10-03 Flannelly Barry P Sale 1000.0000
2018-10-03 SWAIN PAULA J Sale 10000.0000
2018-10-03 Trower Paul Sale 10000.0000
2018-11-08 BIENAIME JEAN JACQUES Purchase 500.0000
2018-11-08 BIENAIME JEAN JACQUES Purchase 500.0000
2019-01-04 SWAIN PAULA J Sale 30000.0000
2019-01-07 Trower Paul Sale 9187.0000
2019-01-07 Wenqing Yao Sale 10000.0000
2019-01-08 Flannelly Barry P Sale 1714.0000
2019-01-15 Trower Paul Sale 5813.0000
2019-01-17 Wenqing Yao Sale 15354.0000
2019-01-28 Flannelly Barry P Sale 1000.0000
2019-02-01 SWAIN PAULA J Sale 10000.0000
2019-03-01 SWAIN PAULA J Sale 10000.0000
2019-04-01 SWAIN PAULA J Sale 1782.0000
2019-04-01 SWAIN PAULA J Sale 8218.0000
2019-06-17 SWAIN PAULA J Sale 2500.0000
2019-06-24 Stein Steven H Sale 8357.0000
2019-07-15 SWAIN PAULA J Sale 2500.0000
2019-07-17 Flannelly Barry P Sale 959.0000
2019-08-01 BIENAIME JEAN JACQUES Sale 1347.0000
2019-08-02 BIENAIME JEAN JACQUES Sale 377.0000
2019-08-02 FRIEDMAN PAUL A Sale 22066.0000
2019-08-06 FRIEDMAN PAUL A Sale 77934.0000
2019-08-15 SWAIN PAULA J Sale 2500.0000
2019-09-17 Flannelly Barry P Sale 2491.0000
2019-09-18 SWAIN PAULA J Sale 2500.0000
2019-10-22 SWAIN PAULA J Sale 2500.0000
2019-10-29 Iyengar Vijay K Sale 930.0000
2019-10-29 Trower Paul Sale 6601.0000
2019-10-29 Trower Paul Sale 8399.0000
2019-10-29 Trower Paul Sale 1500.0000
2019-10-29 Wenqing Yao Sale 2040.0000
2019-11-01 Trower Paul Sale 8500.0000
2019-11-01 Wenqing Yao Sale 7960.0000
2019-11-06 DIXON WENDY L Sale 10576.0000
2019-11-07 DIXON WENDY L Sale 1540.0000
2019-11-08 DIXON WENDY L Sale 22884.0000
2019-11-08 DIXON WENDY L Sale 18334.0000
2019-11-15 SWAIN PAULA J Sale 2500.0000
2019-11-25 Trower Paul Sale 15000.0000
2019-11-25 Wenqing Yao Sale 15000.0000
2019-11-25 Flannelly Barry P Sale 422.0000
2019-11-25 Flannelly Barry P Sale 1720.0000
2019-11-29 Flannelly Barry P Sale 600.0000
2019-11-29 Iyengar Vijay K Sale 500.0000
2019-11-29 Wenqing Yao Sale 3165.0000
2019-12-02 Flannelly Barry P Sale 6582.0000
2019-12-02 Iyengar Vijay K Sale 7366.0000
2019-12-02 Wenqing Yao Sale 16835.0000
2019-12-16 SWAIN PAULA J Sale 2500.0000
2020-01-15 SWAIN PAULA J Sale 2500.0000
2020-02-05 Wenqing Yao Sale 17542.0000
2020-02-19 SWAIN PAULA J Sale 2500.0000
2020-03-31 SWAIN PAULA J Sale 1639.0000
2020-03-31 SWAIN PAULA J Sale 690.0000
2020-04-06 Dhanak Dashyant Sale 3844.0000
2020-04-06 Pasquale Maria E Sale 1842.0000
2020-04-13 Pasquale Maria E Sale 965.0000
2020-04-14 Pasquale Maria E Sale 17827.0000
2020-04-16 Pasquale Maria E Sale 9488.0000
2020-04-17 Pasquale Maria E Sale 9488.0000
2020-04-17 Flannelly Barry P Sale 6583.0000
2020-04-17 Trower Paul Sale 1143.0000
2020-05-06 Dhanak Dashyant Sale 961.0000
2020-05-28 BAKER BROS. ADVISORS LP Purchase 1.0000
2020-05-28 BAKER BROS. ADVISORS LP Purchase 1.0000
2020-06-08 Dhanak Dashyant Sale 961.0000
2020-06-10 Pasquale Maria E Sale 1423.0000
2020-06-10 Pasquale Maria E Sale 2192.0000
2020-06-19 Flannelly Barry P Sale 7181.0000
2020-06-19 Iyengar Vijay K Sale 7866.0000
2020-06-19 Pasquale Maria E Sale 1423.0000
2020-06-22 Dickinson Jonathan Elliott Sale 9000.0000
2020-06-23 Flannelly Barry P Sale 400.0000
2020-06-23 Trower Paul Sale 6943.0000
2020-06-26 Hoppenot Herve Sale 4647.0000
2020-06-26 Hoppenot Herve Sale 119501.0000
2020-07-06 Dhanak Dashyant Sale 961.0000
2020-07-06 Stein Steven H Sale 2522.0000
2020-07-06 Stein Steven H Sale 596.0000
2020-07-06 Stein Steven H Sale 12132.0000
2020-07-06 Stein Steven H Sale 10437.0000
2020-07-06 Stein Steven H Sale 10437.0000
2020-07-06 Wenqing Yao Sale 905.0000
2020-07-06 Wenqing Yao Sale 15648.0000
2020-07-07 Hoppenot Herve Sale 1365.0000
2020-07-07 Hoppenot Herve Sale 88406.0000
2020-07-07 Stein Steven H Sale 3381.0000
2020-07-07 Stein Steven H Sale 7495.0000
2020-07-07 Stein Steven H Sale 3283.0000
2020-07-07 Iyengar Vijay K Sale 3120.0000
2020-07-08 Stein Steven H Sale 610.0000
2020-07-08 Iyengar Vijay K Sale 475.0000
2020-07-16 Stein Steven H Sale 766.0000
2020-08-06 Dhanak Dashyant Sale 961.0000
2020-08-27 DIXON WENDY L Sale 20000.0000
2020-09-08 Dhanak Dashyant Sale 961.0000
2020-09-10 Pasquale Maria E Sale 2193.0000
2020-10-06 Dhanak Dashy Sale 961
2020-10-09 Pasquale Maria E Sale 1423
2020-11-02 Flannelly Barry P Sale 20000
2020-11-06 Dhanak Dashy Sale 961
2020-11-10 BIENAIME JEAN JACQUES Sale 798
2021-01-25 Wenqing Y Sale 19986
2021-01-25 Wenqing Y Sale 1559
2021-01-25 Stein Steven H Sale 3795
2021-01-25 Iyengar Vijay K Sale 1000
2021-01-25 Iyengar Vijay K Sale 4116
2021-01-25 Flannelly Barry P Sale 2744
2021-02-01 Dhanak Dashy Sale 395
2021-02-01 Dhanak Dashy Sale 961
2021-02-23 Hoppenot Herv Purchase 12925
Transaction Date) Insider Transaction Type Number of Shares Transacted